CASIA OpenIR  > 中国科学院分子影像重点实验室
Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting
Jiang, Bing1,2; Jia, Xiaohua3; Ji, Tianjiao4,5; Zhou, Meng2; He, Jiuyang2; Wang, Kun3; Tian, Jie3,6; Yan, Xiyun1,2; Fan, Kelong1,2
Source PublicationSCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
2021-08-31
Pages13
Abstract

Engineered nanocarriers have been widely developed for tumor theranostics. However, the delivery of imaging probes or therapeutic drugs to the tumor pre-formation site for early and accurate detection and therapy remains a major challenge. Here, by using tailor-functionalized human H-ferritin (HFn), we developed a triple-modality nanoprobe IRdye800-M-HFn and achieved the early imaging of tumor cells before the formation of solid tumor tissues. Then, we developed an HFn-doxorubicin (Dox) drug delivery system by loading Dox into the HFn protein cage and achieved early-stage tumor therapy. The intravenous injection of HFn nanoprobes enabled the imaging of tumor cells as early as two days after tumor implantation, and the triple-modality imaging techniques, namely, near-infrared fluorescence molecular imaging (NIR-FMI), magnetic resonance imaging (MRI), and photoacoustic imaging (PAI), ensured the accuracy of detection. Further exploration indicated that HFn could specifically penetrate into pre-solid tumor sites by tumor-associated inflammation-mediated blood vessel leakage, followed by effective accumulation in tumor cells by the specific targeting property of HFn to transferrin receptor 1. Thus, the HFn-Dox drug delivery system delivered Dox into the tumor pre-formation site and effectively killed tumor cells at early stage. IRDye800-M-HFn nanoprobes and HFn-Dox provide promising strategies for early-stage tumor diagnosis and constructive implications for early-stage tumor treatment.

Keywordferritin nanocage early theranostics tumor-associated inflammation multimodality tumor imaging drug delivery
DOI10.1007/s11427-021-1976-0
WOS KeywordBLOOD-BRAIN-BARRIER ; HEPATOCELLULAR-CARCINOMA ; H-FERRITIN ; CANCER ; NANOPARTICLES ; TRANSFERRIN ; CELLS ; PERMEABILITY ; DOXORUBICIN ; DIAGNOSIS
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31900981] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[32000996] ; Strategic Priority Research Program of CAS[XDB29040101] ; CAS Inter-disciplinary Innovation Team[JCTD-2020-08] ; Chinese Academy of Sciences[YJKYYQ20180048] ; Key Research Program of Frontier Sciences, CAS[QYZDY-SSW-SMC013] ; National Key Research and Development Program of China[2017YFA0205501] ; National Key Research and Development Program of China[2017YFA0205200] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2019093] ; China Postdoctoral Science Foundation[2020M682358] ; China Postdoctoral Science Special Foundation[2020TQ0280] ; Grant for International Joint Research Project of the Institute of Medical Science, the University of Tokyo[Extension-2019-K3005] ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program[19JCZDJC65300] ; CAS Key Laboratory of Mental Health[KLMH2020K02]
Funding OrganizationNational Natural Science Foundation of China ; Strategic Priority Research Program of CAS ; CAS Inter-disciplinary Innovation Team ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences, CAS ; National Key Research and Development Program of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Special Foundation ; Grant for International Joint Research Project of the Institute of Medical Science, the University of Tokyo ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program ; CAS Key Laboratory of Mental Health
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS IDWOS:000693359700004
PublisherSCIENCE PRESS
Sub direction classification医学影像处理与分析
planning direction of the national heavy laboratory其他
Paper associated data
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Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/45963
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie; Yan, Xiyun; Fan, Kelong
Affiliation1.Zhengzhou Univ, Nanozyme Med Ctr, Sch Basic Med Sci, Zhengzhou 450001, Peoples R China
2.Chinese Acad Sci, Inst Biophys, CAS Engn Lab Nanozyme, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Ctr Excellence Nanosci, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China
6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Bing,Jia, Xiaohua,Ji, Tianjiao,et al. Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting[J]. SCIENCE CHINA-LIFE SCIENCES,2021:13.
APA Jiang, Bing.,Jia, Xiaohua.,Ji, Tianjiao.,Zhou, Meng.,He, Jiuyang.,...&Fan, Kelong.(2021).Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting.SCIENCE CHINA-LIFE SCIENCES,13.
MLA Jiang, Bing,et al."Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting".SCIENCE CHINA-LIFE SCIENCES (2021):13.
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