Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting

doi:10.1007/s11427-021-1976-0

	Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting
	Jiang, Bing 1,2; Jia, Xiaohua3 ; Ji, Tianjiao 4,5; Zhou, Meng 2; He, Jiuyang 2; Wang, Kun3 ; Tian, Jie 3,6; Yan, Xiyun 1,2; Fan, Kelong 1,2
发表期刊	SCIENCE CHINA-LIFE SCIENCES
ISSN	1674-7305
	2021-08-31
页码	13
通讯作者	Tian, Jie(pe.tian@ia.ac.cn) ; Yan, Xiyun(yanxy@ibp.ac.cn) ; Fan, Kelong(fankelong@ibp.ac.cn)
摘要	Engineered nanocarriers have been widely developed for tumor theranostics. However, the delivery of imaging probes or therapeutic drugs to the tumor pre-formation site for early and accurate detection and therapy remains a major challenge. Here, by using tailor-functionalized human H-ferritin (HFn), we developed a triple-modality nanoprobe IRdye800-M-HFn and achieved the early imaging of tumor cells before the formation of solid tumor tissues. Then, we developed an HFn-doxorubicin (Dox) drug delivery system by loading Dox into the HFn protein cage and achieved early-stage tumor therapy. The intravenous injection of HFn nanoprobes enabled the imaging of tumor cells as early as two days after tumor implantation, and the triple-modality imaging techniques, namely, near-infrared fluorescence molecular imaging (NIR-FMI), magnetic resonance imaging (MRI), and photoacoustic imaging (PAI), ensured the accuracy of detection. Further exploration indicated that HFn could specifically penetrate into pre-solid tumor sites by tumor-associated inflammation-mediated blood vessel leakage, followed by effective accumulation in tumor cells by the specific targeting property of HFn to transferrin receptor 1. Thus, the HFn-Dox drug delivery system delivered Dox into the tumor pre-formation site and effectively killed tumor cells at early stage. IRDye800-M-HFn nanoprobes and HFn-Dox provide promising strategies for early-stage tumor diagnosis and constructive implications for early-stage tumor treatment.
关键词	ferritin nanocage early theranostics tumor-associated inflammation multimodality tumor imaging drug delivery
DOI	10.1007/s11427-021-1976-0
关键词[WOS]	BLOOD-BRAIN-BARRIER ; HEPATOCELLULAR-CARCINOMA ; H-FERRITIN ; CANCER ; NANOPARTICLES ; TRANSFERRIN ; CELLS ; PERMEABILITY ; DOXORUBICIN ; DIAGNOSIS
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31900981] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[32000996] ; Strategic Priority Research Program of CAS[XDB29040101] ; CAS Inter-disciplinary Innovation Team[JCTD-2020-08] ; Chinese Academy of Sciences[YJKYYQ20180048] ; Key Research Program of Frontier Sciences, CAS[QYZDY-SSW-SMC013] ; National Key Research and Development Program of China[2017YFA0205501] ; National Key Research and Development Program of China[2017YFA0205200] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2019093] ; China Postdoctoral Science Foundation[2020M682358] ; China Postdoctoral Science Special Foundation[2020TQ0280] ; Grant for International Joint Research Project of the Institute of Medical Science, the University of Tokyo[Extension-2019-K3005] ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program[19JCZDJC65300] ; CAS Key Laboratory of Mental Health[KLMH2020K02]
项目资助者	National Natural Science Foundation of China ; Strategic Priority Research Program of CAS ; CAS Inter-disciplinary Innovation Team ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences, CAS ; National Key Research and Development Program of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Special Foundation ; Grant for International Joint Research Project of the Institute of Medical Science, the University of Tokyo ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program ; CAS Key Laboratory of Mental Health
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:000693359700004
出版者	SCIENCE PRESS
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/45963
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Yan, Xiyun; Fan, Kelong
作者单位	1.Zhengzhou Univ, Nanozyme Med Ctr, Sch Basic Med Sci, Zhengzhou 450001, Peoples R China 2.Chinese Acad Sci, Inst Biophys, CAS Engn Lab Nanozyme, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Ctr Excellence Nanosci, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China 6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Bing,Jia, Xiaohua,Ji, Tianjiao,et al. Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting[J]. SCIENCE CHINA-LIFE SCIENCES,2021:13.
APA	Jiang, Bing.,Jia, Xiaohua.,Ji, Tianjiao.,Zhou, Meng.,He, Jiuyang.,...&Fan, Kelong.(2021).Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting.SCIENCE CHINA-LIFE SCIENCES,13.
MLA	Jiang, Bing,et al."Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting".SCIENCE CHINA-LIFE SCIENCES (2021):13.