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Alterations in white matter fractional anisotropy in subsyndromal perimenopausal depression | |
其他题名 | Alterations in white matter fractional anisotropy in subsyndromal perimenopausal depression |
Wang, Xianglan1; Tao, Jiong1; Li, Lingjiang1; Zhong, Zhiyong1; Liu, Sha4; Jiang, Tianzi5; Zhang, Jinbei2 | |
发表期刊 | BMC PSYCHIATRY |
ISSN | 1471-244X |
2014 | |
卷号 | 14期号:1 |
摘要 | Background: Subsyndromal depression (SSD) is considered as a predictor for future depressive disorders, however whether white matter abnormalities are involved in the high-susceptibility of women to depressive disorders during perimenopause is unknown. The purpose of this study was to investigate fractional anisotropy (FA) in the white matter of the whole brain in perimenopausal women with SSD using diffusion tensor imaging (DTI). |
其他摘要 | Background Subsyndromal depression (SSD) is considered as a predictor for future depressive disorders, however whether white matter abnormalities are involved in the high-susceptibility of women to depressive disorders during perimenopause is unknown. The purpose of this study was to investigate fractional anisotropy (FA) in the white matter of the whole brain in perimenopausal women with SSD using diffusion tensor imaging (DTI). Methods In a cross-sectional study, 24 perimenopausal women with SSD and 24 other age-, education-, and body mass index-matched healthy women underwent DTI. A voxel-based analysis was used to elucidate regional FA changes at a voxel threshold of p ?0.001 with an extent threshold of k ?>?127voxels ( p ?0.05, AlphaSim correction). Subsequently, correlation analyses were performed between mean FA values in significant brain regions and plasma estradiol level. Results Compared to healthy controls, women with SSD exhibited significantly lower FA values in the left insula, while higher FA values were observed in the left ventral lateral thalamus and left and right brainstem in the midbrain. In subjects with SSD, the mean FA value in the left insula was positively correlated to plasma estradiol levels ( r ?=?0.453, p ?=?0.026) (uncorrected). Conclusions Our findings indicate altered microstructures in white matter of the insula and subcortical regions may be associated with the high susceptibility of perimenopausal women to depressive disorders. Estrogen may modulate the white matter microstructure of the insula. |
语种 | 英语 |
资助项目 | [National Natural Science Foundation of China] ; [National Basic Research Program of China] ; [Science and Technology Program of Guangdong, China] |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/46093 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 1.Central South University 2.Sun Yat Sen University 3.Shenzhen Kangning Hosp Guangdong Prov 4.Guangzhou Brain Hosp 5.Institute of Automation, Chinese Academy of Sciences 6.University of Queensland 7.University of Electronic Science & Technology of China |
推荐引用方式 GB/T 7714 | Wang, Xianglan,Tao, Jiong,Li, Lingjiang,et al. Alterations in white matter fractional anisotropy in subsyndromal perimenopausal depression[J]. BMC PSYCHIATRY,2014,14(1). |
APA | Wang, Xianglan.,Tao, Jiong.,Li, Lingjiang.,Zhong, Zhiyong.,Liu, Sha.,...&Zhang, Jinbei.(2014).Alterations in white matter fractional anisotropy in subsyndromal perimenopausal depression.BMC PSYCHIATRY,14(1). |
MLA | Wang, Xianglan,et al."Alterations in white matter fractional anisotropy in subsyndromal perimenopausal depression".BMC PSYCHIATRY 14.1(2014). |
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