CASIA OpenIR  > 中国科学院分子影像重点实验室
In vivo fluorescence molecular imaging of the vascular endothelial growth factor in rats with early diabetic retinopathy
Zhang, Lu1,2,3; Ding, Yunhe1,2,3; Chen, Xinjian4,5; Xiang, Dehui4,5; Shi, Fei4,5; Chen, Yanyun6; Yan, Shenshen6; Zhang, Xinyuan6; Tian, Jie3; Siva Prasad, Sobha7; Du, Yang3; Yang, Zhi1,2; Tian, Bei6
Source PublicationBIOMEDICAL OPTICS EXPRESS
ISSN2156-7085
2021-11-01
Volume12Issue:11Pages:7185-7198
Corresponding AuthorDu, Yang(yang.du@ia.ac.cn)
AbstractAnti-vascular endothelial growth factor (anti-VEGF) therapy is effective for reducing the severity level of diabetic retinopathy (DR). However, it is difficult to determine the in vivo spatial and temporal expression of VEGF in the DR retina at an early stage. Here, we report a quantitatively fluorescence molecular imaging and image analysis method by creating a VEGF targeted fluorescence imaging probe, which can potentially detect and predict anti-VEGF treatment response. Moreover, the ex vivo multiscale fluorescence imaging demonstrated the spatial correlation between VEGF relative expression and vascular abnormalities in two and three dimensions. It revealed that VEGF was mainly abnormally expressed at the bifurcation of the microvessels, which advances the knowledge of the DR progression by molecular fluorescence imaging. Our study has the potential to achieve early detection of DR disease, provide more insight into understanding anti-VEGF treatment, and may help stratify patients based on the molecular imaging of retinal VEGF.
DOI10.1364/BOE.439446
WOS KeywordMAJOR RISK-FACTORS ; GLOBAL PREVALENCE ; VEGF ; NEUTRALIZATION ; RANIBIZUMAB ; BEVACIZUMAB ; AFLIBERCEPT ; PROGRESSION
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[61771326] ; National Natural Science Foundation of China[61827809] ; Science and Technology Project of Beijing Municipal Commission of Education[KM202010025026]
Funding OrganizationNational Natural Science Foundation of China ; Science and Technology Project of Beijing Municipal Commission of Education
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000717641100003
PublisherOPTICAL SOC AMER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/46516
Collection中国科学院分子影像重点实验室
Corresponding AuthorDu, Yang
Affiliation1.Capital Med Univ, Sch Biomed Engn, Beijing 100069, Peoples R China
2.Capital Med Univ, Beijing Key Lab Fundamental Res Biomech Clin Appl, Beijing 100069, Peoples R China
3.Inst Automat, Chinese Acad Sci, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Soochow Univ, Sch Elect & Informat Engn, Suzhou 215006, Jiangsu, Peoples R China
5.Soochow Univ, State Key Lab Radiat Med & Protect, Suzhou 215006, Jiangsu, Peoples R China
6.Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China
7.Moorfields Eye Hosp, NIHR Moorfields Biomed Res Ctr, London EC1V 2PD, England
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Lu,Ding, Yunhe,Chen, Xinjian,et al. In vivo fluorescence molecular imaging of the vascular endothelial growth factor in rats with early diabetic retinopathy[J]. BIOMEDICAL OPTICS EXPRESS,2021,12(11):7185-7198.
APA Zhang, Lu.,Ding, Yunhe.,Chen, Xinjian.,Xiang, Dehui.,Shi, Fei.,...&Tian, Bei.(2021).In vivo fluorescence molecular imaging of the vascular endothelial growth factor in rats with early diabetic retinopathy.BIOMEDICAL OPTICS EXPRESS,12(11),7185-7198.
MLA Zhang, Lu,et al."In vivo fluorescence molecular imaging of the vascular endothelial growth factor in rats with early diabetic retinopathy".BIOMEDICAL OPTICS EXPRESS 12.11(2021):7185-7198.
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