Knowledge Commons of Institute of Automation，CAS
| Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells | |
Liu, Jing1,2,3 ; Wang, Shengxiong4,5; Lu, Yan5,6,7,8; Wang, Haoyu5,6,7,8; Wang, Fangfang5; Qiu, Miaoxin4; Xie, Qiwei9; Han, Hua1,2,3; Hua, Yunfeng5,6,7,8
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| 发表期刊 | NEUROSCIENCE BULLETIN
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| ISSN | 1673-7067 |
| 2021-11-27 | |
| 页码 | 14 |
| 通讯作者 | Han, Hua(hua.han@ia.ac.cn) ; Hua, Yunfeng(yunfeng.hua@shsmu.edu.cn) |
| 摘要 | Recent studies have revealed great functional and structural heterogeneity in the ribbon-type synapses at the basolateral pole of the isopotential inner hair cell (IHC). This feature is believed to be critical for audition over a wide dynamic range, but whether the spatial gradient of ribbon morphology is fine-tuned in each IHC and how the mitochondrial network is organized to meet local energy demands of synaptic transmission remain unclear. By means of three-dimensional electron microscopy and artificial intelligence-based algorithms, we demonstrated the cell-wide structural quantification of ribbons and mitochondria in mature mid-cochlear IHCs of mice. We found that adjacent IHCs in staggered pairs differ substantially in cell body shape and ribbon morphology gradient as well as mitochondrial organization. Moreover, our analysis argues for a location-specific arrangement of correlated ribbon and mitochondrial function at the basolateral IHC pole. |
| 关键词 | Inner hair cell Ribbon synapse Mitochondrial network Volume electron microscopy AI-based image processing |
| DOI | 10.1007/s12264-021-00801-w |
| 关键词[WOS] | QUANTITATIVE-ANALYSIS ; RESPONSE PROPERTIES ; NERVE FIBERS ; CAT COCHLEA ; AFFERENT ; RECONSTRUCTION ; HETEROGENEITY ; INNERVATION ; GRADIENTS ; VESICLES |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[81800901] ; Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning[QD2018015] ; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases[14DZ2260300] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32030200] ; Bureau of International Cooperation, Chinese Academy of Sciences[153D31KYSB20170059] |
| 项目资助者 | National Natural Science Foundation of China ; Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning ; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Bureau of International Cooperation, Chinese Academy of Sciences |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| WOS记录号 | WOS:000722958700001 |
| 出版者 | SPRINGER |
| 七大方向——子方向分类 | 脑网络分析 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/46549 |
| 专题 | 脑图谱与类脑智能实验室_微观重建与智能分析 |
| 通讯作者 | Han, Hua; Hua, Yunfeng |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Artificial Intelligence, Sch Future Technol, Beijing 101408, Peoples R China 3.CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China 4.Tongji Univ, Putuo Peoples Hosp, Shanghai 200060, Peoples R China 5.Shanghai Jiao Tong Univ, Peoples Hosp 9, Shanghai Inst Precis Med, Sch Med, Shanghai 200125, Peoples R China 6.Shanghai Ninth Peoples Hosp, Dept OtolaryngologyHead & Neck Surg, Shanghai 200125, Peoples R China 7.Shanghai Jiao Tong Univ, Ear Inst, Sch Med, Shanghai 200125, Peoples R China 8.Shanghai Key Lab Translat Med Ear & Nose Dis, Shanghai 200125, Peoples R China 9.Beijing Univ Technol, Res Base Beijing Modern Mfg Dev, Beijing 100124, Peoples R China |
| 第一作者单位 | 模式识别国家重点实验室 |
| 通讯作者单位 | 模式识别国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, Jing,Wang, Shengxiong,Lu, Yan,et al. Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells[J]. NEUROSCIENCE BULLETIN,2021:14. |
| APA | Liu, Jing.,Wang, Shengxiong.,Lu, Yan.,Wang, Haoyu.,Wang, Fangfang.,...&Hua, Yunfeng.(2021).Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells.NEUROSCIENCE BULLETIN,14. |
| MLA | Liu, Jing,et al."Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells".NEUROSCIENCE BULLETIN (2021):14. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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