Characterization of metabolic landscape in hepatocellular carcinoma

doi:10.4251/wjgo.v13.i9.1144

	Characterization of metabolic landscape in hepatocellular carcinoma
	Wu, Jing 1; Xue, Ran 2; Jiang, Rong-Tao3 ; Meng, Qing-Hua 1
发表期刊	WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
ISSN	1948-5204
	2021-09-15
卷号	13 期号:9 页码:1144-1156
通讯作者	Meng, Qing-Hua(meng_qh0805@ccmu.edu.cn)
摘要	Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide, accounting for approximately 75%-85% of primary liver cancers. Metabolic alterations have been labeled as an emerging hallmark of tumors. Specially, the last decades have registered a significant improvement in our understanding of the role of metabolism in driving the carcinogenesis and progression of HCC. In this paper, we provide a review of recent studies that investigated the metabolic traits of HCC with a specific focus on three common metabolic alterations involving glycolysis, lipid metabolism, and glutamine addiction which have been gaining much attention in the field of HCC. Next, we describe some representative diagnostic markers or tools, and promising treatment agents that are proposed on the basis of the aforementioned metabolic alterations for HCC. Finally, we present some challenges and directions that may promisingly speed up the process of developing objective diagnostic markers and therapeutic options underlying HCC. Specifically, we recommend future investigations to carefully take into account the influence of heterogeneity, control for study-specific confounds, and invite the validation of existing biomarkers.
关键词	Hepatocellular carcinoma Metabolic reprogramming Glycolysis Lipid metabolism Glutamine addiction Diagnosis and treatment
DOI	10.4251/wjgo.v13.i9.1144
关键词[WOS]	LIVER-CANCER ; THERAPEUTIC TARGET ; GLUCOSE-METABOLISM ; ACID ; SORAFENIB ; GROWTH ; CELLS ; RESISTANCE ; EXPRESSION ; BIOMARKERS
收录类别	SCI
语种	英语
资助项目	Municipal Natural Science Foundation of Beijing, China[7192085] ; National Science and Technology Major Project of China[2018ZX10302206-003-007] ; National Science and Technology Major Project of China[2017ZX10203202-001-005] ; Capital Health Research and Development of Special[20181-3011] ; National Natural Science Foundation of China[81470877]
项目资助者	Municipal Natural Science Foundation of Beijing, China ; National Science and Technology Major Project of China ; Capital Health Research and Development of Special ; National Natural Science Foundation of China
WOS研究方向	Oncology ; Gastroenterology & Hepatology
WOS类目	Oncology ; Gastroenterology & Hepatology
WOS记录号	WOS:000736478800013
出版者	BAISHIDENG PUBLISHING GROUP INC
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/47134
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Meng, Qing-Hua
作者单位	1.Capital Med Univ, Beijing You An Hosp, Dept Med Oncol, 8 Xi Tou Tiao, Beijing 100069, Peoples R China 2.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100036, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wu, Jing,Xue, Ran,Jiang, Rong-Tao,et al. Characterization of metabolic landscape in hepatocellular carcinoma[J]. WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY,2021,13(9):1144-1156.
APA	Wu, Jing,Xue, Ran,Jiang, Rong-Tao,&Meng, Qing-Hua.(2021).Characterization of metabolic landscape in hepatocellular carcinoma.WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY,13(9),1144-1156.
MLA	Wu, Jing,et al."Characterization of metabolic landscape in hepatocellular carcinoma".WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY 13.9(2021):1144-1156.