Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice

doi:10.1016/j.isci.2021.103450

	Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice
	Zhou, Xiaoqing Alice 1; Blackmore, Daniel G.1; Zhuo, Junjie1,3 ; Nasrallah, Fatima A.1,2; To, XuanVinh 1; Kurniawan, Nyoman D.2; Carlisle, Alison 1; Vien, King-Year 1; Chuang, Kai-Hsiang 1,2; Jiang, Tianzi1,3 ; Bartlett, Perry F.1
发表期刊	ISCIENCE
	2021-12-17
卷号	24 期号:12 页码:20
通讯作者	Chuang, Kai-Hsiang(k.chuang@uq.edu.au) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) ; Bartlett, Perry F.(p.bartlett@uq.edu.au)
摘要	We have shown that the improvement in hippocampal-based learning in aged mice following physical exercise observed is dependent on neurogenesis in the dentate gyrus (DG) and is regulated by changes in growth hormone levels. The changes in neurocircuitry, however, which may underlie this improvement, remain unclear. Using in vivo multimodal magnetic resonance imaging to track changes in aged mice exposed to exercise, we show the improved spatial learning is due to enhanced DG connectivity, particularly the strengthening of the DG-Cornu Ammonis 3 and the DG-medial entorhinal cortex connections in the dorsal hippocampus. Moreover, we provide evidence that these changes in circuitry are dependent on neurogenesis since they were abrogated by ablation of newborn neurons following exercise. These findings identify the specific changes in hippocampal circuitry that underlie the cognitive improvements resulting from physical activity and show that they are dependent on the activation of neurogenesis in aged animals.
DOI	10.1016/j.isci.2021.103450
关键词[WOS]	ACTIVE PLACE AVOIDANCE ; FUNCTIONAL CONNECTIVITY ; VENTRAL HIPPOCAMPUS ; PATTERN SEPARATION ; DENTATE GYRUS ; MEMORY ; DORSAL ; VOLUME ; CELLS ; PROLIFERATION
收录类别	SCI
语种	英语
资助项目	National Health and Medical Research Council[GNT1130141] ; Stafford Fox Medical Research Foundation
项目资助者	National Health and Medical Research Council ; Stafford Fox Medical Research Foundation
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000740254100001
出版者	CELL PRESS
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/47170
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Chuang, Kai-Hsiang; Jiang, Tianzi; Bartlett, Perry F.
作者单位	1.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 2.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld 4072, Australia 3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Xiaoqing Alice,Blackmore, Daniel G.,Zhuo, Junjie,et al. Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice[J]. ISCIENCE,2021,24(12):20.
APA	Zhou, Xiaoqing Alice.,Blackmore, Daniel G..,Zhuo, Junjie.,Nasrallah, Fatima A..,To, XuanVinh.,...&Bartlett, Perry F..(2021).Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice.ISCIENCE,24(12),20.
MLA	Zhou, Xiaoqing Alice,et al."Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice".ISCIENCE 24.12(2021):20.