CASIA OpenIR  > 中国科学院分子影像重点实验室
Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer
Liu,Yu1,2,3,5; Shang,Wenting3; Liu,Heng4; Hui,Hui3; Wu,Jun3; Zhang,Wei3; Gao,Pengli1,3,5; Guo,Kunxiong3; Guo,Yanli2; Tian,Jie1,3,5,6
Source PublicationJournal of Nanobiotechnology
Corresponding AuthorGuo,Yanli( ; Tian,Jie(
AbstractAbstractPro-tumoral and immunosuppressive M2-like tumor-associated macrophages (TAMs) contribute to tumor progression, recurrence and distal metastasis. However, current TAMs-modulating therapeutic strategies often encounter challenges including insufficient immune activation, weak antigen presentation ability and unsatisfactory antitumor immune performance. Herein, cyclic RGD peptide functionalized and manganese doped eumelanin-like nanocomposites (RMnMels) are reported for combined hyperthermia-immunotherapy against PC3 prostate cancer. The RMnMels could promote M2-to-M1 macrophage repolarization via scavenging multiple reactive oxygen species and remodeling the immunosuppressive tumor microenvironment. Following near-infrared light irradiation, RMnMels-mediated thermal ablation not only could destroy tumor cells directly, but also elicit the release of damage associated molecular patterns and tumor-associated antigens, provoking robust tumor immunogenicity and strong antitumor immune responses. The results showed that RMnMels could effectively scavenge reactive oxygen species and promote M2-to-M1 macrophage repolarization both in vitro and in vivo. Synergistically enhanced anti-tumor therapeutic efficacy was achieved following single administration of RMnMels plus single round of laser irradiation, evidenced by decreased primary tumor sizes and decreased number of distant liver metastatic nodules. The as-developed RMnMels may represent a simple and high-performance therapeutic nanoplatform for immunomodulation and enhanced antitumor immune responses.Graphical Abstract
KeywordTumor-associated macrophages Immunomodulation Hyperthermia-immunotherapy Eumelanin Prostate cancer
WOS IDBMC:10.1186/s12951-022-01248-5
PublisherBioMed Central
Citation statistics
Document Type期刊论文
Corresponding AuthorGuo,Yanli; Tian,Jie
Affiliation1.Beihang University; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering
2.Army Medical University; Department of Ultrasound, Southwest Hospital
3.Chinese Academy of Sciences; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation
4.PLA Rocket Force Characteristic Medical Center; Department of Radiology
5.Beihang University, Ministry of Industry and Information Technology; Key Laboratory of Big Data-Based Precision Medicine
6.Xidian University; Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology
Recommended Citation
GB/T 7714
Liu,Yu,Shang,Wenting,Liu,Heng,et al. Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer[J]. Journal of Nanobiotechnology,2022,20(1).
APA Liu,Yu.,Shang,Wenting.,Liu,Heng.,Hui,Hui.,Wu,Jun.,...&Tian,Jie.(2022).Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer.Journal of Nanobiotechnology,20(1).
MLA Liu,Yu,et al."Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer".Journal of Nanobiotechnology 20.1(2022).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu,Yu]'s Articles
[Shang,Wenting]'s Articles
[Liu,Heng]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu,Yu]'s Articles
[Shang,Wenting]'s Articles
[Liu,Heng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu,Yu]'s Articles
[Shang,Wenting]'s Articles
[Liu,Heng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.