Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer

doi:10.1186/s12951-022-01248-5

	Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer
	Liu,Yu 1,2,3,5; Shang,Wenting3 ; Liu,Heng 4; Hui,Hui3 ; Wu,Jun 3; Zhang,Wei3 ; Gao,Pengli 1,3,5; Guo,Kunxiong 3; Guo,Yanli 2; Tian,Jie1,3,5,6
Source Publication	Journal of Nanobiotechnology
	2022-01-24
Volume	20 Issue:1
Corresponding Author	Guo,Yanli(guoyanli71@aliyun.com) ; Tian,Jie(jie.tian@ia.ac.cn)
Abstract	AbstractPro-tumoral and immunosuppressive M2-like tumor-associated macrophages (TAMs) contribute to tumor progression, recurrence and distal metastasis. However, current TAMs-modulating therapeutic strategies often encounter challenges including insufficient immune activation, weak antigen presentation ability and unsatisfactory antitumor immune performance. Herein, cyclic RGD peptide functionalized and manganese doped eumelanin-like nanocomposites (RMnMels) are reported for combined hyperthermia-immunotherapy against PC3 prostate cancer. The RMnMels could promote M2-to-M1 macrophage repolarization via scavenging multiple reactive oxygen species and remodeling the immunosuppressive tumor microenvironment. Following near-infrared light irradiation, RMnMels-mediated thermal ablation not only could destroy tumor cells directly, but also elicit the release of damage associated molecular patterns and tumor-associated antigens, provoking robust tumor immunogenicity and strong antitumor immune responses. The results showed that RMnMels could effectively scavenge reactive oxygen species and promote M2-to-M1 macrophage repolarization both in vitro and in vivo. Synergistically enhanced anti-tumor therapeutic efficacy was achieved following single administration of RMnMels plus single round of laser irradiation, evidenced by decreased primary tumor sizes and decreased number of distant liver metastatic nodules. The as-developed RMnMels may represent a simple and high-performance therapeutic nanoplatform for immunomodulation and enhanced antitumor immune responses.Graphical Abstract
Keyword	Tumor-associated macrophages Immunomodulation Hyperthermia-immunotherapy Eumelanin Prostate cancer
DOI	10.1186/s12951-022-01248-5
Language	英语
WOS ID	BMC:10.1186/s12951-022-01248-5
Publisher	BioMed Central
Citation statistics
Document Type	期刊论文
Identifier	http://ir.ia.ac.cn/handle/173211/47198
Collection	中国科学院分子影像重点实验室
Corresponding Author	Guo,Yanli; Tian,Jie
Affiliation	1.Beihang University; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering 2.Army Medical University; Department of Ultrasound, Southwest Hospital 3.Chinese Academy of Sciences; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation 4.PLA Rocket Force Characteristic Medical Center; Department of Radiology 5.Beihang University, Ministry of Industry and Information Technology; Key Laboratory of Big Data-Based Precision Medicine 6.Xidian University; Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology
Recommended Citation GB/T 7714	Liu,Yu,Shang,Wenting,Liu,Heng,et al. Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer[J]. Journal of Nanobiotechnology,2022,20(1).
APA	Liu,Yu.,Shang,Wenting.,Liu,Heng.,Hui,Hui.,Wu,Jun.,...&Tian,Jie.(2022).Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer.Journal of Nanobiotechnology,20(1).
MLA	Liu,Yu,et al."Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer".Journal of Nanobiotechnology 20.1(2022).

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