Carbon-Based Fiber Materials as Implantable Depth Neural Electrodes

doi:10.3389/fnins.2021.771980

	Carbon-Based Fiber Materials as Implantable Depth Neural Electrodes
	Fu, Xuefeng 1; Li, Gen1 ; Niu, Yutao 2,3; Xu, Jingcao 4; Wang, Puxin 1,5; Zhou, Zhaoxiao 1,5; Ye, Ziming 4; Liu, Xiaojun 1; Xu, Zheng 1; Yang, Ziqian 1,5; Zhang, Yongyi 2,3; Lei, Ting 4; Zhang, Baogui6 ; Li, Qingwen 2,3; Cao, Anyuan 4; Jiang, Tianzai 6; Duan, Xiaojie 1,5,7
发表期刊	FRONTIERS IN NEUROSCIENCE
	2021-12-22
卷号	15 页码:12
通讯作者	Duan, Xiaojie(xjduan@pku.edu.cn)
摘要	Implantable brain electrophysiology electrodes are valuable tools in both fundamental and applied neuroscience due to their ability to record neural activity with high spatiotemporal resolution from shallow and deep brain regions. Their use has been hindered, however, by the challenges in achieving chronically stable operations. Furthermore, implantable depth neural electrodes can only carry out limited data sampling within predefined anatomical regions, making it challenging to perform large-area brain mapping. Minimizing inflammatory responses and associated gliosis formation, and improving the durability and stability of the electrode insulation layers are critical to achieve long-term stable neural recording and stimulation. Combining electrophysiological measurements with simultaneous whole-brain imaging techniques, such as magnetic resonance imaging (MRI), provides a useful solution to alleviate the challenge in scalability of implantable depth electrodes. In recent years, various carbon-based materials have been used to fabricate flexible neural depth electrodes with reduced inflammatory responses and MRI-compatible electrodes, which allows structural and functional MRI mapping of the whole brain without obstructing any brain regions around the electrodes. Here, we conducted a systematic comparative evaluation on the electrochemical properties, mechanical properties, and MRI compatibility of different kinds of carbon-based fiber materials, including carbon nanotube fibers, graphene fibers, and carbon fibers. We also developed a strategy to improve the stability of the electrode insulation without sacrificing the flexibility of the implantable depth electrodes by sandwiching an inorganic barrier layer inside the polymer insulation film. These studies provide us with important insights into choosing the most suitable materials for next-generation implantable depth electrodes with unique capabilities for applications in both fundamental and translational neuroscience research.
关键词	brain activity mapping multi-modal neural interfacing soft bioelectronics carbon nanomaterials biocompatibility
DOI	10.3389/fnins.2021.771980
关键词[WOS]	STIMULATION ; COPPER ; INTERFACES ; FILMS ; SOFT ; MICROELECTRODES ; BIOMATERIALS ; PROTECTION ; PROGRESS ; DESIGN
收录类别	SCI
语种	英语
资助项目	Beijing Natural Science Foundation[JQ20008] ; National Natural Science Foundation of China[21972005] ; National Basic Research Program of China[2016YFA0200103] ; Beijing Graphene Innovation Program[Z191100000819001]
项目资助者	Beijing Natural Science Foundation ; National Natural Science Foundation of China ; National Basic Research Program of China ; Beijing Graphene Innovation Program
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000745249600001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/47314
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Duan, Xiaojie
作者单位	1.Peking Univ, Coll Future Technol, Dept Biomed Engn, Beijing, Peoples R China 2.Univ Sci & Technol China, Sch Nanotech & Nanob, Hefei, Peoples R China 3.Chinese Acad Sci, Key Lab Multifunct Nanomat & Smart Syst, Adv Mat Div, Suzhou Inst Nanotech & Nanob, Suzhou, Peoples R China 4.Peking Univ, Sch Mat Sci & Engn, Beijing, Peoples R China 5.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 7.Peking Univ, Natl Biomed Imaging Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Fu, Xuefeng,Li, Gen,Niu, Yutao,et al. Carbon-Based Fiber Materials as Implantable Depth Neural Electrodes[J]. FRONTIERS IN NEUROSCIENCE,2021,15:12.
APA	Fu, Xuefeng.,Li, Gen.,Niu, Yutao.,Xu, Jingcao.,Wang, Puxin.,...&Duan, Xiaojie.(2021).Carbon-Based Fiber Materials as Implantable Depth Neural Electrodes.FRONTIERS IN NEUROSCIENCE,15,12.
MLA	Fu, Xuefeng,et al."Carbon-Based Fiber Materials as Implantable Depth Neural Electrodes".FRONTIERS IN NEUROSCIENCE 15(2021):12.