| The human mediodorsal thalamus: Organization, connectivity, and function | |
Li, Kaixin1,2,3; Fan, Lingzhong2,3,4,5 ; Cui, Yue2,3,5; Wei, Xuehu6; He, Yini7; Yang, Jiyue2,3,5; Lu, Yuheng2,3,5; Li, Wen2,3,5; Shi, Weiyang2,3,5; Cao, Long2,3,8; Cheng, Luqi2,3,9; Li, Ang10; You, Bo1; Jiang, Tianzi2,3,4,5,8,11
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| 发表期刊 | NEUROIMAGE
 |
| ISSN | 1053-8119 |
| 2022-04-01 | |
| 卷号 | 249页码:10 |
| 通讯作者 | You, Bo(youbo@hrbust.edu.cn) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) |
| 摘要 | The human mediodorsal thalamic nucleus (MD) is crucial for higher cognitive functions, while the fine anatomical organization of the MD and the function of each subregion remain elusive. In this study, using high-resolution data provided by the Human Connectome Project, an anatomical connectivity-based method was adopted to unveil the topographic organization of the MD. Four fine-grained subregions were identified in each hemisphere, including the medial (MDm), central (MDc), dorsal (MDd), and lateral (MDl), which recapitulated previous cytoarchitectonic boundaries from histological studies. The subsequent connectivity analysis of the subregions also demonstrated distinct anatomical and functional connectivity patterns, especially with the prefrontal cortex. To further evaluate the function of MD subregions, partial least squares analysis was performed to examine the relationship between different prefrontal-subregion connectivity and behavioral measures in 1012 subjects. The results showed subregion-specific involvement in a range of cognitive functions. Specifically, the MDm predominantly subserved emotional-cognition domains, while the MDl was involved in multiple cognitive functions especially cognitive flexibility and inhibition. The MDc and MDd were correlated with fluid intelligence, processing speed, and emotional cognition. In conclusion, our work provides new insights into the anatomical and functional organization of the MD and highlights the various roles of the prefrontal-thalamic circuitry in human cognition. |
| 关键词 | Mediodorsal thalamic nucleus Parcellation Anatomical organization Functional connectivity Cognitive functions |
| DOI | 10.1016/j.neuroimage.2022.118876 |
| 关键词[WOS] | PREFRONTAL CORTEX ; NUCLEUS ; PROJECTIONS ; ATLAS ; PARCELLATION ; NEURONS |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[91432302] ; National Natural Science Foundation of China[31620103905] ; National Natural Science Foundation of China[82072099] ; National Natural Science Foundation of China[31771076] ; Science Frontier Program of the Chinese Academy of Sciences[QYZDJ-SSW-SMC019] ; Beijing Municipal Science and Technology Commission[Z161100000216139] ; Beijing Municipal Science and Technology Commission[Z171100000117002] ; Beijing Advanced Discipline Fund ; Guangdong Pearl River Talents Plan[2016ZT06S220] ; McDonnell Center for Systems Neuroscience at Washington University ; [1U54MH091657] |
| 项目资助者 | National Natural Science Foundation of China ; Science Frontier Program of the Chinese Academy of Sciences ; Beijing Municipal Science and Technology Commission ; Beijing Advanced Discipline Fund ; Guangdong Pearl River Talents Plan ; McDonnell Center for Systems Neuroscience at Washington University |
| WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS记录号 | WOS:000752568400006 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 七大方向——子方向分类 | 脑网络分析 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/47621 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 通讯作者 | You, Bo; Jiang, Tianzi |
| 作者单位 | 1.Harbin Univ Sci & Technol, Sch Mech & Power Engn, Harbin 150080, Peoples R China 2.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 3.Chinese Acad Sci Beijing, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100190, Peoples R China 6.Max Planck Inst Human Cognit & Brain Sci, Dept Neuropsychol, Leipzig, Germany 7.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China 8.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 9.Guilin Univ Elect Technol, Sch Life & Environm Sci, Guilin 541004, Peoples R China 10.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 11.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia |
| 第一作者单位 | 模式识别国家重点实验室 |
| 通讯作者单位 | 模式识别国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Kaixin,Fan, Lingzhong,Cui, Yue,et al. The human mediodorsal thalamus: Organization, connectivity, and function[J]. NEUROIMAGE,2022,249:10. |
| APA | Li, Kaixin.,Fan, Lingzhong.,Cui, Yue.,Wei, Xuehu.,He, Yini.,...&Jiang, Tianzi.(2022).The human mediodorsal thalamus: Organization, connectivity, and function.NEUROIMAGE,249,10. |
| MLA | Li, Kaixin,et al."The human mediodorsal thalamus: Organization, connectivity, and function".NEUROIMAGE 249(2022):10. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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