Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor

doi:10.1186/s12951-022-01325-9

	Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor
	Qu,Qiaojun 1,2; Zhang,Zeyu2,3 ; Guo,Xiaoyong 2,4,5; Yang,Junying 6; Cao,Caiguang 2,7; Li,Changjian 3; Zhang,Hui 8; Xu,Pengfei 9; Hu,Zhenhua2,7 ; Tian,Jie1,2,3,7
Source Publication	Journal of Nanobiotechnology
	2022-03-19
Volume	20 Issue:1 Pages:15
Corresponding Author	Zhang,Hui(zhang_hui@sxmu.edu.cn) ; Xu,Pengfei(pengfeixuscu@outlook.com) ; Hu,Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian,Jie(jie.tian@ia.ac.cn)
Abstract	AbstractIncomplete tumor resection is the direct cause of the tumor recurrence and metastasis after surgery. Intraoperative accurate detection and elimination of microscopic residual cancer improve surgery outcomes. In this study, a powerful D1–π–A–D2–R type phototheranostic based on aggregation-induced emission (AIE)-active the second near-infrared window (NIR-II) fluorophore is designed and constructed. The prepared theranostic agent, A1 nanoparticles (NPs), simultaneously shows high absolute quantum yield (1.23%), excellent photothermal conversion efficiency (55.3%), high molar absorption coefficient and moderate singlet oxygen generation performance. In vivo experiments indicate that NIR-II fluorescence imaging of A1 NPs precisely detect microscopic residual tumor (2?mm in diameter) in the tumor bed and metastatic lymph nodes. More notably, a novel integrated strategy that achieves complete tumor eradication (no local recurrence and metastasis after surgery) is proposed. In summary, A1 NPs possess superior imaging and treatment performance, and can detect and eliminate residual tumor lesions intraoperatively. This work provides a promising technique for future clinical applications achieving improved surgical outcomes.Graphic Abstract
Keyword	Aggregation-induced emission NIR-II imaging Phototherapy Phototheranostic Residual tumor
DOI	10.1186/s12951-022-01325-9
WOS Keyword	BREAST-CONSERVING SURGERY ; CANCER ; IRRADIATION ; MARGINS ; ANTIGEN
Indexed By	SCI
Language	英语
Funding Project	National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[62027901] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[92059207] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[82102236] ; Beijing Natural Science Foundation[JQ19027] ; Youth Crossover Team Project of the Chinese Academy of Sciences[JCTD-2021-08] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16021200] ; Zhuhai High-level Health Personnel Team Project (Zhuhai)[HLHPTP201703] ; China Postdoctoral Science Foundation[2021M690007] ; the innovative research team of high-level local universities in Shanghai
Funding Organization	National Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Beijing Natural Science Foundation ; Youth Crossover Team Project of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Zhuhai High-level Health Personnel Team Project (Zhuhai) ; China Postdoctoral Science Foundation ; the innovative research team of high-level local universities in Shanghai
WOS Research Area	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS Subject	Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS ID	BMC:10.1186/s12951-022-01325-9
Publisher	BioMed Central
Citation statistics
Document Type	期刊论文
Identifier	http://ir.ia.ac.cn/handle/173211/47643
Collection	中国科学院分子影像重点实验室
Corresponding Author	Zhang,Hui; Xu,Pengfei; Hu,Zhenhua; Tian,Jie
Affiliation	1.Shanxi Medical University; College of Medical Imaging 2.Chinese Academy of Sciences; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation 3.Beihang University; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering 4.Chinese PLA General Hospital; Department of Gastroenterology, The Third Medical Centre 5.Anhui Medical University 6.Southern Medical University; Department of Hepatobiliary Surgery, Zhujiang Hospital 7.University of Chinese Academy of Sciences; School of Artificial Intelligence 8.First Hospital of Shanxi Medical University; Department of Radiology 9.Jining Medical University; Institute of Clinical Pharmacy & Pharmacology, Jining First People’s Hospital
Recommended Citation GB/T 7714	Qu,Qiaojun,Zhang,Zeyu,Guo,Xiaoyong,et al. Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor[J]. Journal of Nanobiotechnology,2022,20(1):15.
APA	Qu,Qiaojun.,Zhang,Zeyu.,Guo,Xiaoyong.,Yang,Junying.,Cao,Caiguang.,...&Tian,Jie.(2022).Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor.Journal of Nanobiotechnology,20(1),15.
MLA	Qu,Qiaojun,et al."Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor".Journal of Nanobiotechnology 20.1(2022):15.

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