Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor

doi:10.1186/s12951-022-01325-9

	Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor
	Qu,Qiaojun 1,2; Zhang,Zeyu2,3 ; Guo,Xiaoyong 2,4,5; Yang,Junying 6; Cao,Caiguang2,7 ; Li,Changjian 3; Zhang,Hui 8; Xu,Pengfei 9; Hu,Zhenhua2,7 ; Tian,Jie 1,2,3,7
发表期刊	Journal of Nanobiotechnology
	2022-03-19
卷号	20 期号:1 页码:15
通讯作者	Zhang,Hui(zhang_hui@sxmu.edu.cn) ; Xu,Pengfei(pengfeixuscu@outlook.com) ; Hu,Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian,Jie(jie.tian@ia.ac.cn)
摘要	AbstractIncomplete tumor resection is the direct cause of the tumor recurrence and metastasis after surgery. Intraoperative accurate detection and elimination of microscopic residual cancer improve surgery outcomes. In this study, a powerful D1–π–A–D2–R type phototheranostic based on aggregation-induced emission (AIE)-active the second near-infrared window (NIR-II) fluorophore is designed and constructed. The prepared theranostic agent, A1 nanoparticles (NPs), simultaneously shows high absolute quantum yield (1.23%), excellent photothermal conversion efficiency (55.3%), high molar absorption coefficient and moderate singlet oxygen generation performance. In vivo experiments indicate that NIR-II fluorescence imaging of A1 NPs precisely detect microscopic residual tumor (2?mm in diameter) in the tumor bed and metastatic lymph nodes. More notably, a novel integrated strategy that achieves complete tumor eradication (no local recurrence and metastasis after surgery) is proposed. In summary, A1 NPs possess superior imaging and treatment performance, and can detect and eliminate residual tumor lesions intraoperatively. This work provides a promising technique for future clinical applications achieving improved surgical outcomes.Graphic Abstract
关键词	Aggregation-induced emission NIR-II imaging Phototherapy Phototheranostic Residual tumor
DOI	10.1186/s12951-022-01325-9
关键词[WOS]	BREAST-CONSERVING SURGERY ; CANCER ; IRRADIATION ; MARGINS ; ANTIGEN
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[62027901] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[92059207] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[82102236] ; Beijing Natural Science Foundation[JQ19027] ; Youth Crossover Team Project of the Chinese Academy of Sciences[JCTD-2021-08] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16021200] ; Zhuhai High-level Health Personnel Team Project (Zhuhai)[HLHPTP201703] ; China Postdoctoral Science Foundation[2021M690007] ; the innovative research team of high-level local universities in Shanghai
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Beijing Natural Science Foundation ; Youth Crossover Team Project of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Zhuhai High-level Health Personnel Team Project (Zhuhai) ; China Postdoctoral Science Foundation ; the innovative research team of high-level local universities in Shanghai
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS类目	Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS记录号	BMC:10.1186/s12951-022-01325-9
出版者	BioMed Central
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/47643
专题	中国科学院分子影像重点实验室
通讯作者	Zhang,Hui; Xu,Pengfei; Hu,Zhenhua; Tian,Jie
作者单位	1.Shanxi Medical University; College of Medical Imaging 2.Chinese Academy of Sciences; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation 3.Beihang University; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering 4.Chinese PLA General Hospital; Department of Gastroenterology, The Third Medical Centre 5.Anhui Medical University 6.Southern Medical University; Department of Hepatobiliary Surgery, Zhujiang Hospital 7.University of Chinese Academy of Sciences; School of Artificial Intelligence 8.First Hospital of Shanxi Medical University; Department of Radiology 9.Jining Medical University; Institute of Clinical Pharmacy & Pharmacology, Jining First People’s Hospital
推荐引用方式 GB/T 7714	Qu,Qiaojun,Zhang,Zeyu,Guo,Xiaoyong,et al. Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor[J]. Journal of Nanobiotechnology,2022,20(1):15.
APA	Qu,Qiaojun.,Zhang,Zeyu.,Guo,Xiaoyong.,Yang,Junying.,Cao,Caiguang.,...&Tian,Jie.(2022).Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor.Journal of Nanobiotechnology,20(1),15.
MLA	Qu,Qiaojun,et al."Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor".Journal of Nanobiotechnology 20.1(2022):15.