| Dynamic reconfiguration of human brain networks across altered states of consciousness | |
Liu, Haiyang1; Hu, Ke2,3,4; Peng, Yingjie5,6; Tian, Xiaohan5; Wang, Meng2,3,4; Ma, Bo1; Wu, Youxuan1; Sun, Wanchen1; Liu, Bing6,7 ; Li, Ang5,8; Han, Ruquan1
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| Source Publication | BEHAVIOURAL BRAIN RESEARCH
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| ISSN | 0166-4328 |
| 2022-02-15 | |
| Volume | 419Pages:11 |
| Corresponding Author | Li, Ang(al@ibp.ac.cn) ; Han, Ruquan(ruquan.han@ccmu.edu.cn) |
| Abstract | Consciousness is supported by rich neuronal dynamics to orchestrate behaviors and conscious processing can be disrupted by general anesthetics. Previous studies suggested that dynamic reconfiguration of large-scale functional network is critical for learning and higher-order cognitive function. During altered states of consciousness, how brain functional networks are dynamically changed and reconfigured at the whole-brain level is still unclear. To fill this gap, using multilayer network approach and functional magnetic resonance imaging (fMRI) data of 21 healthy subjects, we investigated the dynamic network reconfiguration in three different states of consciousness: wakefulness, dexmedetomidine-induced sedation, and recovery. Applying time-varying community detection algorithm, we constructed multilayer modularity networks to track and quantify dynamic interactions among brain areas that span time and space. We compared four high-level network features (i.e., switching, promiscuity, integration, and recruitment) derived from multilayer modularity across the three conditions. We found that sedation state is primarily characterized by increased switching rates as well as decreased integration, representing a whole-brain pattern with higher modular dynamics and more fragmented communication; such alteration can be mostly reversed after the recovery of consciousness. Thus, our work can provide additional insights to understand the modular network reconfiguration across different states of consciousness and may provide some clinical implications for disorders of consciousness. |
| Keyword | Functional magnetic resonance imaging Multilayer networks Dynamic functional connectivity Consciousness Sedation Dexmedetomidine |
| DOI | 10.1016/j.bbr.2021.113685 |
| WOS Keyword | RESTING-STATE ; FUNCTIONAL CONNECTIVITY ; TIME ; MODULARITY ; THALAMUS ; CORTEX ; SLEEP |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Institutional Review Board of Beijing Tiantan Hospital, China[KY2017-036-02] ; Beijing Natural Science Foundation Program, China[7192055] ; Strategic Priority Research Program (B) of the Chinese Academy of Sciences, China[XDB32020200] |
| Funding Organization | Institutional Review Board of Beijing Tiantan Hospital, China ; Beijing Natural Science Foundation Program, China ; Strategic Priority Research Program (B) of the Chinese Academy of Sciences, China |
| WOS Research Area | Behavioral Sciences ; Neurosciences & Neurology |
| WOS Subject | Behavioral Sciences ; Neurosciences |
| WOS ID | WOS:000754453200003 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/47913 |
| Collection | 脑网络组研究 |
| Corresponding Author | Li, Ang; Han, Ruquan |
| Affiliation | 1.Capital Med Univ, Beijing Tiantan Hosp, Dept Anesthesiol, Beijing, Peoples R China 2.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 6.Shandong Normal Univ, Sch Informat, Jinan 250013, Peoples R China 7.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Haiyang,Hu, Ke,Peng, Yingjie,et al. Dynamic reconfiguration of human brain networks across altered states of consciousness[J]. BEHAVIOURAL BRAIN RESEARCH,2022,419:11. |
| APA | Liu, Haiyang.,Hu, Ke.,Peng, Yingjie.,Tian, Xiaohan.,Wang, Meng.,...&Han, Ruquan.(2022).Dynamic reconfiguration of human brain networks across altered states of consciousness.BEHAVIOURAL BRAIN RESEARCH,419,11. |
| MLA | Liu, Haiyang,et al."Dynamic reconfiguration of human brain networks across altered states of consciousness".BEHAVIOURAL BRAIN RESEARCH 419(2022):11. |
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