Targeted-detection and sequential-treatment of small hepatocellular carcinoma in the complex liver environment by GPC-3-targeted nanoparticles

doi:10.1186/s12951-022-01378-w

	Targeted-detection and sequential-treatment of small hepatocellular carcinoma in the complex liver environment by GPC-3-targeted nanoparticles
	Deng,Han 1,2; Shang,Wenting2 ; Wang,Kun2 ; Guo,Kunxiong 1,2; Liu,Yu2 ; Tian,Jie 1,2,3; Fang,Chihua 1,4
发表期刊	Journal of Nanobiotechnology
	2022-03-24
卷号	20 期号:1 页码:20
通讯作者	Tian,Jie(jie.tian@ia.ac.cn) ; Fang,Chihua(zjyyfangchihua@smu.edu.cn)
摘要	AbstractDespite advancements in diagnostic methods and therapeutic strategies, the mortality rate of hepatocellular carcinoma (HCC) remains as high as its incidence rate. Most liver cancers are detected in the advanced stages, when treatment options are limited. Small HCC is difficult to diagnose and is often overlooked by current imaging methods because of the complexity of the liver environment, especially in cirrhotic livers. In the present study, we developed a tumor “cruise missile”, mesoporous Fe3O4-containing glucose oxidase-conjugated GPC3 peptide nanoparticles (FGP NPs). It was designed to enhance the accuracy of small HCC visualization to 85.7% using combined ultrasound/photoacoustic imaging in complex liver environment, which facilitated sequential catalytic targeted therapy for small HCC. In a carcinogen-induced mouse HCC model, FGP NPs could be used to accurately diagnose HCC in a liver cirrhosis background as well as distinguish HCC nodules from other abnormal liver nodules, such as cirrhosis nodules and necrotic nodules, by dynamic contrast-enhanced photoacoustic imaging. In a mouse xenograft HCC model, highly reactive oxygen species were formed by sequential catalytic reactions, which promoted HCC cell apoptosis, significantly increasing the survival of the model mice. The present study provides a basis for the precise detection and elimination of small HCCs in the complex liver environment.Graphical Abstract
关键词	Small hepatocellular carcinoma Complex liver environment Targeted detection Dynamic contrast-enhanced photoacoustic imaging Sequential catalysis-targeted therapy
DOI	10.1186/s12951-022-01378-w
关键词[WOS]	PHOTOACOUSTIC TOMOGRAPHY ; SURVEILLANCE ; DIAGNOSIS ; NODULES
收录类别	SCI
语种	英语
资助项目	Ministry of Science and Technology of China[2017YFA0205200] ; Ministry of Science and Technology of China[2016YFC0106500] ; Ministry of Science and Technology of China[2017YFA0700401] ; National Natural Science Foundation of China[81627805] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81971680] ; National Natural Science Foundation of China[81930048] ; National Natural Science Foundation of China[22077108] ; NSFC-GD Union Foundation[U1401254]
项目资助者	Ministry of Science and Technology of China ; National Natural Science Foundation of China ; NSFC-GD Union Foundation
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS类目	Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS记录号	BMC:10.1186/s12951-022-01378-w
出版者	BioMed Central
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/47931
专题	中国科学院分子影像重点实验室
通讯作者	Tian,Jie; Fang,Chihua
作者单位	1.Southern Medical University; Department of Hepatobiliary Surgery, Institute for Digital Intelligence, Zhujiang Hospital 2.Chinese Academy of Sciences; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation 3.Beihang University; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering 4.Provincial Clinical and Engineering Center of Digital Medicine
推荐引用方式 GB/T 7714	Deng,Han,Shang,Wenting,Wang,Kun,et al. Targeted-detection and sequential-treatment of small hepatocellular carcinoma in the complex liver environment by GPC-3-targeted nanoparticles[J]. Journal of Nanobiotechnology,2022,20(1):20.
APA	Deng,Han.,Shang,Wenting.,Wang,Kun.,Guo,Kunxiong.,Liu,Yu.,...&Fang,Chihua.(2022).Targeted-detection and sequential-treatment of small hepatocellular carcinoma in the complex liver environment by GPC-3-targeted nanoparticles.Journal of Nanobiotechnology,20(1),20.
MLA	Deng,Han,et al."Targeted-detection and sequential-treatment of small hepatocellular carcinoma in the complex liver environment by GPC-3-targeted nanoparticles".Journal of Nanobiotechnology 20.1(2022):20.