Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI | |
Jiang, Hanyu1; Wei, Jingwei2,3 ; Fu, Fangfang4,5; Wei, Hong1; Qin, Yun1; Duan, Ting1; Chen, Weixia1; Xie, Kunlin6; Lee, Jeong Min7,8; Bashir, Mustafa R.9,10,11; Wang, Meiyun4,5; Song, Bin1; Tian, Jie2,3,12,13,14
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| Source Publication | LIVER INTERNATIONAL
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| ISSN | 1478-3223 |
| 2022-03-11 | |
| Pages | 15 |
| Corresponding Author | Wang, Meiyun(mywang@ha.edu.cn) ; Song, Bin(anicesong@vip.sina.com) ; Tian, Jie(jie.tian@ia.ac.cn) |
| Abstract | Background & Aims Microvascular invasion (MVI) is an important risk factor in hepatocellular carcinoma (HCC), but its diagnosis mandates postoperative histopathologic analysis. We aimed to develop and externally validate a predictive scoring system for MVI. Methods From July 2015 to November 2020, consecutive patients underwent surgery for HCC with preoperative gadoxetate disodium (EOB)-enhanced MRI was retrospectively enrolled. All MR images were reviewed independently by two radiologists who were blinded to the outcomes. In the training centre, a radio-clinical MVI score was developed via logistic regression analysis against pathology. In the testing centre, areas under the receiver operating curve (AUCs) of the MVI score and other previous MVI schemes were compared. Overall survival (OS) and recurrence-free survival (RFS) were analysed by the Kaplan-Meier method with the log-rank test. Results A total of 417 patients were included, 195 (47%) with pathologically-confirmed MVI. The MVI score included: non-smooth tumour margin (odds ratio [OR] = 4.4), marked diffusion restriction (OR = 3.0), internal artery (OR = 3.0), hepatobiliary phase peritumoral hypointensity (OR = 2.5), tumour multifocality (OR = 1.6), and serum alpha-fetoprotein >400 ng/mL (OR = 2.5). AUCs for the MVI score were 0.879 (training) and 0.800 (testing), significantly higher than those for other MVI schemes (testing AUCs: 0.648-0.684). Patients with model-predicted MVI had significantly shorter OS (median 61.0 months vs not reached, P < .001) and RFS (median 13.0 months vs. 42.0 months, P < .001) than those without. Conclusions A preoperative MVI score integrating five EOB-MRI features and serum alpha-fetoprotein level could accurately predict MVI and postoperative survival in HCC. Therefore, this score may aid in individualized treatment decision making. |
| Keyword | diagnosis gadoxetate disodium-enhanced MRI hepatocellular carcinoma microvascular invasion survival |
| DOI | 10.1111/liv.15231 |
| WOS Keyword | COMPUTED-TOMOGRAPHY ; RECURRENCE ; DIAGNOSIS ; RESECTION ; NOMOGRAM ; SYSTEM ; CANCER |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[82101997] ; National Natural Science Foundation of China[62027 901] ; National Natural Science Foundation of China[81 227 901] ; National Natural Science Foundation of China[81 930 053] ; National Natural Science Foundation of China[82 001917] ; Science and Technology Support Program of Sichuan Province[2021YFS0141] ; Science and Technology Support Program of Sichuan Province[2021YFS0021] ; Ministry of Science and Technology of China[2017YFA0205200] ; Project of High-Level Talents Team Introduction in Zhuhai City[HLHPTP201703] |
| Funding Organization | National Natural Science Foundation of China ; Science and Technology Support Program of Sichuan Province ; Ministry of Science and Technology of China ; Project of High-Level Talents Team Introduction in Zhuhai City |
| WOS Research Area | Gastroenterology & Hepatology |
| WOS Subject | Gastroenterology & Hepatology |
| WOS ID | WOS:000767145200001 |
| Publisher | WILEY |
| Sub direction classification | 医学影像处理与分析 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/47943 |
| Collection | 中国科学院分子影像重点实验室 |
| Corresponding Author | Wang, Meiyun; Song, Bin; Tian, Jie |
| Affiliation | 1.Sichuan Univ, West China Hosp, Dept Radiol, Chengdu 610041, Sichuan, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Beijing Key Lab Mol Imaging, Beijing, Peoples R China 4.Henan Prov Peoples Hosp, Dept Med Imaging, Zhengzhou 450003, Henan, Peoples R China 5.Zhengzhou Univ, Dept Med Imaging, Peoples Hosp, Zhengzhou, Peoples R China 6.Sichuan Univ, West China Hosp, Dept Liver Surg & Liver Transplantat, Chengdu, Peoples R China 7.Seoul Natl Univ Hosp, Dept Radiol, Seoul, South Korea 8.Seoul Natl Univ, Coll Med, Seoul, South Korea 9.Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA 10.Duke Univ, Med Ctr, Ctr Adv Magnet Resonance Med, Durham, NC USA 11.Duke Univ, Med Ctr, Div Gastroenterol, Durham, NC 27710 USA 12.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing, Peoples R China 13.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China 14.Beihang Univ, Minist Ind & Informat Technol, Key Lab Big Data Based Precis Med, Beijing, Peoples R China |
| Corresponding Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Jiang, Hanyu,Wei, Jingwei,Fu, Fangfang,et al. Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI[J]. LIVER INTERNATIONAL,2022:15. |
| APA | Jiang, Hanyu.,Wei, Jingwei.,Fu, Fangfang.,Wei, Hong.,Qin, Yun.,...&Tian, Jie.(2022).Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI.LIVER INTERNATIONAL,15. |
| MLA | Jiang, Hanyu,et al."Predicting microvascular invasion in hepatocellular carcinoma: A dual-institution study on gadoxetate disodium-enhanced MRI".LIVER INTERNATIONAL (2022):15. |
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