Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| Intraoperative near-infrared fluorescence imaging can identify pelvic nerves in patients with cervical cancer in real time during radical hysterectomy | |
He, Kunshan1,2,3,4,5 ; Li, Pengfei6; Zhang, Zeyu1,2; Liu, Jiaqi6; Liu, Pan6; Gong, Shipeng6; Chi, Chongwei3; Liu, Ping6; Chen, Chunlin6; Tian, Jie1,2,3
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| Source Publication | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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| ISSN | 1619-7070 |
| 2022-03-01 | |
| Pages | 9 |
| Corresponding Author | Chi, Chongwei(chongwei.chi@ia.ac.cn) ; Liu, Ping(lpivy@126.com) ; Chen, Chunlin(ccl1@smu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn) |
| Abstract | Purpose Radical hysterectomy combined with pelvic lymphadenectomy is the standard treatment for early-stage cervical cancer, but unrecognized pelvic nerves are vulnerable to irreversible damage during surgery. This early clinical trial investigated the feasibility and safety of intraoperative near-infrared (NIR) fluorescence imaging (NIR-FI) with indocyanine green (ICG) for identifying pelvic nerves during radical hysterectomy for cervical cancer. Methods Sixty-six adults with cervical cancer were enrolled in this prospective, open-label, single-arm, single-center clinical trial. NIR-FI was performed in vivo to identify genitofemoral (GN), obturator (ON), and hypogastric (HN) nerves intraoperatively. The primary endpoint was the presence of fluorescence in pelvic nerves. Secondary endpoints were the ICG distribution in a nerve specimen and potential underlying causes of fluorescence emission in pelvic nerves. Results In total, 63 patients were analyzed. The ON was visualized bilaterally in 100% (63/63) of patients, with a mean fluorescence signal-to-background ratio (SBR) of 5.3 +/- 2.1. The GN was identified bilaterally in 93.7% (59/63) of patients and unilaterally in the remaining 4 patients, with a mean SBR of 4.1 +/- 1.9. The HN was identified bilaterally in 81.0% (51/63) of patients and unilaterally in 7.9% (5/63) of patients, with a mean SBR of 3.5 +/- 1.3. ICG fluorescence was detected in frozen sections of a nerve specimen, and was mainly distributed in axons. No ICG-related complications were observed. Conclusion This early clinical trial demonstrated the feasibility and safety of NIR-FI to visualize pelvic nerves intraoperatively. Thus, NIR-FI may help surgeons adjust surgical decision-making, avoid nerve damage, and improve surgical outcomes. |
| Keyword | Near-infrared fluorescence imaging Indocyanine green Pelvic nerves Radical hysterectomy Cervical cancer |
| DOI | 10.1007/s00259-022-05686-z |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Ministry of Science and Technology of China[2017YFA0205200] ; Ministry of Science and Technology of China[2019YFC0120800] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[82001984] ; National Natural Science Foundation of China[82102236] ; National Natural Science Foundation of China[82101701] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Beijing Municipal Science & Technology Commission[Z201100006820017] ; Beijing Municipal Science & Technology Commission[Z19111000110000] ; Project of High-Level Talents Team Introduction in Zhuhai City[HLHPTP201703] ; Basic and Applied Basic Research Fund of Guangdong Province[2019A1515110337] ; Basic and Applied Basic Research Fund of Guangdong Province[2021A1515010813] ; Guangdong Medical Science and Technology Research Fund Project[A2020077] ; Nanfang Hospital President Fund[2019C005] |
| Funding Organization | Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission ; Project of High-Level Talents Team Introduction in Zhuhai City ; Basic and Applied Basic Research Fund of Guangdong Province ; Guangdong Medical Science and Technology Research Fund Project ; Nanfang Hospital President Fund |
| WOS Research Area | Radiology, Nuclear Medicine & Medical Imaging |
| WOS Subject | Radiology, Nuclear Medicine & Medical Imaging |
| WOS ID | WOS:000762898800003 |
| Publisher | SPRINGER |
| Sub direction classification | 医学影像处理与分析 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/47958 |
| Collection | 中国科学院分子影像重点实验室 |
| Corresponding Author | Chi, Chongwei; Liu, Ping; Chen, Chunlin; Tian, Jie |
| Affiliation | 1.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Engn Med, Beijing 100191, Peoples R China 2.Beihang Univ, Key Lab Big Data Based Precis Med, Minist Ind & Informat Technol, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Software, State Key Lab Comp Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Software, Beijing Key Lab Human Comp Interact, Beijing, Peoples R China 6.Southern Med Univ, Nanfang Hosp, Dept Obstet & Gynecol, Guangzhou, Peoples R China |
| First Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | He, Kunshan,Li, Pengfei,Zhang, Zeyu,et al. Intraoperative near-infrared fluorescence imaging can identify pelvic nerves in patients with cervical cancer in real time during radical hysterectomy[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2022:9. |
| APA | He, Kunshan.,Li, Pengfei.,Zhang, Zeyu.,Liu, Jiaqi.,Liu, Pan.,...&Tian, Jie.(2022).Intraoperative near-infrared fluorescence imaging can identify pelvic nerves in patients with cervical cancer in real time during radical hysterectomy.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,9. |
| MLA | He, Kunshan,et al."Intraoperative near-infrared fluorescence imaging can identify pelvic nerves in patients with cervical cancer in real time during radical hysterectomy".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022):9. |
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