Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China

doi:10.1007/s00259-022-05730-y

	Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China
	Zhang, Zeyu1,2 ; He, Kunshan2,3,4 ; Chi, Chongwei2,5 ; Hu, Zhenhua2,5 ; Tian, Jie 1,2
发表期刊	EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
ISSN	1619-7070
	2022-03-01
页码	13
通讯作者	Chi, Chongwei(chongwei.chi@ia.ac.cn) ; Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(tian@ieee.org)
摘要	Purpose China has the largest cancer population globally. Surgery is the main choice for most solid cancer patients. Intraoperative fluorescence molecular imaging (FMI) has shown its great potential in assisting surgeons in achieving precise resection. We summarized the typical applications of intraoperative FMI and several new trends to promote the development of precision surgery. Methods The academic database and NIH clinical trial platform were systematically evaluated. We focused on the clinical application of intraoperative FMI in China. Special emphasis was placed on a series of typical studies with new technologies or high-level evidence. The emerging strategy of combining FMI with other modalities was also discussed. Results The clinical applications of clinically approved indocyanine green (ICG), methylene blue (MB), or fluorescein are on the rise in different surgical departments. Intraoperative FMI has achieved precise lesion detection, sentinel lymph node mapping, and lymphangiography for many cancers. Nerve imaging is also exploring to reduce iatrogenic injuries. Through different administration routes, these fluorescent imaging agents provided encouraging results in surgical navigation. Meanwhile, designing new cancer-specific fluorescent tracers is expected to be a promising trend to further improve the surgical outcome. Conclusions Intraoperative FMI is in a rapid development in China. In-depth understanding of cancer-related molecular mechanisms is necessary to achieve precision surgery. Molecular-targeted fluorescent agents and multi-modal imaging techniques might play crucial roles in the era of precision surgery.
关键词	Molecular imaging Precision surgery Cancer surgery Image-guided surgery Molecular-targeted agents Clinical translation
DOI	10.1007/s00259-022-05730-y
关键词[WOS]	NEAR-INFRARED FLUORESCENCE ; INDOCYANINE GREEN ; GUIDED SURGERY ; HEPATOCELLULAR-CARCINOMA ; GASTRIC-CANCER ; LIVER-CANCER ; LUNG-CANCER ; OPEN-LABEL ; RESECTION ; FEASIBILITY
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[62027901] ; National Natural Science Foundation of China (NSFC)[92059207] ; National Natural Science Foundation of China (NSFC)[81930048] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[82102236] ; National Natural Science Foundation of China (NSFC)[82001984] ; National Natural Science Foundation of China (NSFC)[81801864] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Beijing Natural Science Foundation[JQ19027] ; Beijing Municipal Science & Technology Commission[Z201100006820017] ; Beijing Municipal Science & Technology Commission[Z19111000110000] ; China Postdoctoral Science Foundation[2021M690007] ; Zhuhai High-level Health Personnel Team Project[Zhuhai HLHPTP201703] ; innovative research team of high-level local universities in Shanghai
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Chinese Academy of Sciences ; Beijing Natural Science Foundation ; Beijing Municipal Science & Technology Commission ; China Postdoctoral Science Foundation ; Zhuhai High-level Health Personnel Team Project ; innovative research team of high-level local universities in Shanghai
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000762898800004
出版者	SPRINGER
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/47997
专题	中国科学院分子影像重点实验室
通讯作者	Chi, Chongwei; Hu, Zhenhua; Tian, Jie
作者单位	1.Beihang Univ, Sch Engn Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Inst Automat,State Key Lab Management & Control C, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Software, State Key Lab Comp Sci, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Software, Beijing Key Lab Human Comp Interact, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zeyu,He, Kunshan,Chi, Chongwei,et al. Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2022:13.
APA	Zhang, Zeyu,He, Kunshan,Chi, Chongwei,Hu, Zhenhua,&Tian, Jie.(2022).Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,13.
MLA	Zhang, Zeyu,et al."Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022):13.