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Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients
Huang, Jiayuan1,2; Ke, Pengfei1; Chen, Xiaoyi1,2; Li, Shijia1; Zhou, Jing1; Xiong, Dongsheng1; Huang, Yuanyuan3,4; Li, Hehua3,4; Ning, Yuping3,4; Duan, Xujun5; Li, Xiaobo6; Zhang, Wensheng7; Wu, Fengchun3; Wu, Kai2,8,9,10,11,12
Source PublicationFRONTIERS IN AGING NEUROSCIENCE
ISSN1663-4365
2022-03-03
Volume14Pages:11
Corresponding AuthorWu, Fengchun(13580380071@163.com) ; Wu, Kai(kaiwu@scut.edu.cn)
AbstractAccelerated brain aging had been widely reported in patients with schizophrenia (SZ). However, brain aging trajectories in SZ patients have not been well-documented using three-modal magnetic resonance imaging (MRI) data. In this study, 138 schizophrenia patients and 205 normal controls aged 20-60 were included and multimodal MRI data were acquired for each individual, including structural MRI, resting state-functional MRI and diffusion tensor imaging. The brain age of each participant was estimated by features extracted from multimodal MRI data using linear multiple regression. The correlation between the brain age gap and chronological age in SZ patients was best fitted by a positive quadratic curve with a peak chronological age of 47.33 years. We used the peak to divide the subjects into a youth group and a middle age group. In the normal controls, brain age matched chronological age well for both the youth and middle age groups, but this was not the case for schizophrenia patients. More importantly, schizophrenia patients exhibited increased brain age in the youth group but not in the middle age group. In this study, we aimed to investigate brain aging trajectories in SZ patients using multimodal MRI data and revealed an aberrant brain age trajectory in young schizophrenia patients, providing new insights into the pathophysiological mechanisms of schizophrenia.
Keywordschizophrenia accelerated brain aging brain age gap multimodal magnetic resonance imaging machine learning
DOI10.3389/fnagi.2022.823502
WOS KeywordWHITE-MATTER INTEGRITY ; FUNCTIONAL CONNECTIVITY ; INTERNAL CAPSULE ; TREATMENT-NAIVE ; POSTERIOR LIMB ; DRUG-NAIVE ; 1ST-EPISODE ; ABNORMALITIES ; PREDICTION ; NETWORK
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2020YFC2004300] ; National Key Research and Development Program of China[2020YFC2004301] ; National Key Research and Development Program of China[2019YFC0118800] ; National Key Research and Development Program of China[2019YFC0118802] ; National Key Research and Development Program of China[2019YFC0118804] ; National Key Research and Development Program of China[2019YFC0118805] ; National Key Research and Development Program of China[2021YFC2009400] ; National Key Research and Development Program of China[2021YFC2009404] ; National Natural Science Foundation of China[31771074] ; National Natural Science Foundation of China[81802230] ; National Natural Science Foundation of China[72174082] ; Guangdong Basic and Applied Basic Research Foundation Outstanding Youth Project[2021B1515020064] ; Key Research and Development Program of Guangdong[2018B030335001] ; Key Research and Development Program of Guangdong[2020B0101130020] ; Key Research and Development Program of Guangdong[2020B0404010002] ; Science and Technology Program of Guangzhou[201807010064] ; Science and Technology Program of Guangzhou[201803010100] ; Science and Technology Program of Guangzhou[201903010032] ; Science and Technology Program of Guangzhou[202103000032] ; Key Laboratory Program of Guangdong Provincial Education Department[2020KSYS001] ; Open Fund of the Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion[2021B1212040014]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Guangdong Basic and Applied Basic Research Foundation Outstanding Youth Project ; Key Research and Development Program of Guangdong ; Science and Technology Program of Guangzhou ; Key Laboratory Program of Guangdong Provincial Education Department ; Open Fund of the Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000784192000001
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/48311
Collection精密感知与控制研究中心_人工智能与机器学习
Corresponding AuthorWu, Fengchun; Wu, Kai
Affiliation1.South China Univ Technol, Sch Mat Sci & Engn, Dept Biomed Engn, Guangzhou, Peoples R China
2.South China Univ Technol, Sch Biomed Sci & Engn, Guangzhou Int Campus, Guangzhou, Peoples R China
3.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Peoples R China
4.Guangdong Engn Technol Res Ctr Translat Med Menta, Guangzhou, Peoples R China
5.Univ Elect Sci & Technol China, MOE Key Lab Neuroinformat, High Field Magnet Resonance Brain Imaging Key Lab, Chengdu, Peoples R China
6.New Jersey Inst Technol, Dept Biomed Engn, Newark, NJ 07102 USA
7.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
8.South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou, Peoples R China
9.South China Univ Technol, Guangdong Prov Key Lab Biomed Engn, Guangzhou, Peoples R China
10.Guangdong Engn Technol Res Ctr Diag & Rehabil Dem, Guangzhou, Peoples R China
11.Guangdong Second Prov Gen Hosp, Inst Healthcare Artificial Intelligence Applicat, Guangzhou, Peoples R China
12.Tohoku Univ, Inst Dev Aging & Canc, Dept Nucl Med & Radiol, Sendai, Miyagi, Japan
Recommended Citation
GB/T 7714
Huang, Jiayuan,Ke, Pengfei,Chen, Xiaoyi,et al. Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients[J]. FRONTIERS IN AGING NEUROSCIENCE,2022,14:11.
APA Huang, Jiayuan.,Ke, Pengfei.,Chen, Xiaoyi.,Li, Shijia.,Zhou, Jing.,...&Wu, Kai.(2022).Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients.FRONTIERS IN AGING NEUROSCIENCE,14,11.
MLA Huang, Jiayuan,et al."Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients".FRONTIERS IN AGING NEUROSCIENCE 14(2022):11.
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