Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives

doi:10.1007/s11682-022-00681-2

	Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives
	Xie, Sangma1 ; Zhuo, Junjie2 ; Song, Ming3,4,5 ; Chu, Congying3 ; Cui, Yue3,4,5 ; Chen, Yunchun 6; Wang, Huaning 6; Li, Lihua 1; Jiang, Tianzi3,4,5,7
发表期刊	BRAIN IMAGING AND BEHAVIOR
ISSN	1931-7557
	2022-06-22
页码	10
通讯作者	Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
摘要	White matter tracts alterations have been reported in schizophrenia (SZ), but whether such abnormalities are associated with the effects of the disorder itself and/or genetic vulnerability remains unclear. Moreover, the specific patterns of different parts of these altered tracts have been less well studied. Thus, diffusion-weighted images were acquired from 38 healthy controls (HCs), 48 schizophrenia patients, and 33 unaffected first-degree relatives of SZs (FDRs). Diffusion properties of the 25 major tracts automatically extracted with probabilistic tractography were calculated and compared among groups. Regarding the peripheral regions of the tracts, significantly higher diffusivity values in the left superior longitudinal fasciculus (SLF) and the left anterior thalamic radiation (ATR) were observed in SZs than in HCs and unaffected FDRs. However, there were no significant differences between HCs and FDRs in these two tracts. While no main effects of group with respect to the core regions of the 25 tracts survived multiple comparisons correction, FDRs had significantly higher diffusivity values in the left medial lemniscus and lower diffusivity values in the middle cerebellar peduncle than HCs and SZs. These findings enhance the understanding of the abnormal patterns in the peripheral and core regions of the tracts in SZs and those at high genetic risk for schizophrenia. Our results suggest that alterations in the peripheral regions of the left SLF and ATR are features of established illness rather than genetic predisposition, which may serve as critical neural substrates for the psychopathology of schizophrenia.
关键词	Schizophrenia Unaffected first-degree relatives Genetic predisposition White matter tracts Probabilistic tractography
DOI	10.1007/s11682-022-00681-2
关键词[WOS]	SUPERIOR LONGITUDINAL FASCICULUS ; ANTERIOR THALAMIC RADIATION ; 1ST-EPISODE SCHIZOPHRENIA ; BIPOLAR DISORDER ; WORKING-MEMORY ; CONNECTIVITY ; INTEGRITY ; DIFFUSIVITY ; HYPOTHESIS ; PATHWAYS
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of Zhejiang Province[LQ19F030012] ; National Natural Science Foundation of China[61901153] ; National Basic Research Program of China (973)[2011CB707800]
项目资助者	Natural Science Foundation of Zhejiang Province ; National Natural Science Foundation of China ; National Basic Research Program of China (973)
WOS研究方向	Neurosciences & Neurology
WOS类目	Neuroimaging
WOS记录号	WOS:000814493300001
出版者	SPRINGER
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/49168
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Jiang, Tianzi
作者单位	1.Hangzhou Dianzi Univ, Sch Automat, Inst Biomed Engn & Instrumentat, Hangzhou 310018, Peoples R China 2.Hainan Univ, Sch Biomed Engn, Key Lab Biomed Engn Hainan Prov, Haikou 570228, Hainan, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 6.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Peoples R China 7.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
通讯作者单位	中国科学院自动化研究所; 模式识别国家重点实验室
推荐引用方式 GB/T 7714	Xie, Sangma,Zhuo, Junjie,Song, Ming,et al. Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives[J]. BRAIN IMAGING AND BEHAVIOR,2022:10.
APA	Xie, Sangma.,Zhuo, Junjie.,Song, Ming.,Chu, Congying.,Cui, Yue.,...&Jiang, Tianzi.(2022).Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives.BRAIN IMAGING AND BEHAVIOR,10.
MLA	Xie, Sangma,et al."Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives".BRAIN IMAGING AND BEHAVIOR (2022):10.