CASIA OpenIR  > 脑网络组研究
Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives
Xie, Sangma1; Zhuo, Junjie2; Song, Ming3,4,5; Chu, Congying3; Cui, Yue3,4,5; Chen, Yunchun6; Wang, Huaning6; Li, Lihua1; Jiang, Tianzi3,4,5,7
Source PublicationBRAIN IMAGING AND BEHAVIOR
ISSN1931-7557
2022-06-22
Pages10
Corresponding AuthorJiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
AbstractWhite matter tracts alterations have been reported in schizophrenia (SZ), but whether such abnormalities are associated with the effects of the disorder itself and/or genetic vulnerability remains unclear. Moreover, the specific patterns of different parts of these altered tracts have been less well studied. Thus, diffusion-weighted images were acquired from 38 healthy controls (HCs), 48 schizophrenia patients, and 33 unaffected first-degree relatives of SZs (FDRs). Diffusion properties of the 25 major tracts automatically extracted with probabilistic tractography were calculated and compared among groups. Regarding the peripheral regions of the tracts, significantly higher diffusivity values in the left superior longitudinal fasciculus (SLF) and the left anterior thalamic radiation (ATR) were observed in SZs than in HCs and unaffected FDRs. However, there were no significant differences between HCs and FDRs in these two tracts. While no main effects of group with respect to the core regions of the 25 tracts survived multiple comparisons correction, FDRs had significantly higher diffusivity values in the left medial lemniscus and lower diffusivity values in the middle cerebellar peduncle than HCs and SZs. These findings enhance the understanding of the abnormal patterns in the peripheral and core regions of the tracts in SZs and those at high genetic risk for schizophrenia. Our results suggest that alterations in the peripheral regions of the left SLF and ATR are features of established illness rather than genetic predisposition, which may serve as critical neural substrates for the psychopathology of schizophrenia.
KeywordSchizophrenia Unaffected first-degree relatives Genetic predisposition White matter tracts Probabilistic tractography
DOI10.1007/s11682-022-00681-2
WOS KeywordSUPERIOR LONGITUDINAL FASCICULUS ; ANTERIOR THALAMIC RADIATION ; 1ST-EPISODE SCHIZOPHRENIA ; BIPOLAR DISORDER ; WORKING-MEMORY ; CONNECTIVITY ; INTEGRITY ; DIFFUSIVITY ; HYPOTHESIS ; PATHWAYS
Indexed BySCI
Language英语
Funding ProjectNatural Science Foundation of Zhejiang Province[LQ19F030012] ; National Natural Science Foundation of China[61901153] ; National Basic Research Program of China (973)[2011CB707800]
Funding OrganizationNatural Science Foundation of Zhejiang Province ; National Natural Science Foundation of China ; National Basic Research Program of China (973)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000814493300001
PublisherSPRINGER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/49168
Collection脑网络组研究
Corresponding AuthorJiang, Tianzi
Affiliation1.Hangzhou Dianzi Univ, Sch Automat, Inst Biomed Engn & Instrumentat, Hangzhou 310018, Peoples R China
2.Hainan Univ, Sch Biomed Engn, Key Lab Biomed Engn Hainan Prov, Haikou 570228, Hainan, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
6.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Peoples R China
7.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences;  Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xie, Sangma,Zhuo, Junjie,Song, Ming,et al. Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives[J]. BRAIN IMAGING AND BEHAVIOR,2022:10.
APA Xie, Sangma.,Zhuo, Junjie.,Song, Ming.,Chu, Congying.,Cui, Yue.,...&Jiang, Tianzi.(2022).Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives.BRAIN IMAGING AND BEHAVIOR,10.
MLA Xie, Sangma,et al."Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives".BRAIN IMAGING AND BEHAVIOR (2022):10.
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