Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study

doi:10.3389/fnins.2022.919272

	Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study
	Yang, Yongfeng 1,2,3; Li, Xue 1,2,3; Cui, Yue4,5,6 ; Liu, Kang 1,2,3; Qu, Haoyang 7; Lu, Yanli 1; Li, Wenqiang 1,2,3; Zhang, Luwen 1,2,3; Zhang, Yan 1,2,3; Song, Jinggui 1,2,3; Lv, Luxian 1,2,3
发表期刊	FRONTIERS IN NEUROSCIENCE
	2022-06-10
卷号	16 页码:8
通讯作者	Song, Jinggui(songjg62@126.com) ; Lv, Luxian(lvx928@126.com)
摘要	Schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD) are severe psychiatric disorders and share common characteristics not only in clinical symptoms but also in neuroimaging. The purpose of this study was to examine common and specific neuroanatomical features in individuals with these three psychiatric conditions. In this study, 70 patients with SZ, 85 patients with MDD, 42 patients with BD, and 95 healthy controls (HCs) were recruited. Voxel-based morphometry (VBM) analysis was used to explore brain imaging characteristics. Psychopathology was assessed using the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Young Mania Rating Scale (YMRS), and the Positive and Negative Syndrome Scale (PANSS). Cognition was assessed using the digit symbol substitution test (DSST), forward-digital span (DS), backward-DS, and semantic fluency. Common reduced gray matter volume (GMV) in the orbitofrontal cortex (OFC) region was found across the SZ, MDD, and BD. Specific reduced GMV of brain regions was also found. For patients with SZ, we found reduced GMV in the frontal lobe, temporal pole, occipital lobe, thalamus, hippocampus, and cerebellum. For patients with MDD, we found reduced GMV in the frontal and temporal lobes, insular cortex, and occipital regions. Patients with BD had reduced GMV in the medial OFC, inferior temporal and fusiform regions, insular cortex, hippocampus, and cerebellum. Furthermore, the OFC GMV was correlated with processing speed as assessed with the DSST across four groups (r = 0.17, p = 0.004) and correlated with the PANSS positive symptoms sub-score in patients with SZ (r = - 0.27, p = 0.026). In conclusion, common OFC alterations in SZ, MDD, and BD provided evidence that this region dysregulation may play a critical role in the pathophysiology of these three psychiatric disorders.
关键词	schizophrenia major depressive disorder bipolar disorder gray matter volume (GMV) psychopathology
DOI	10.3389/fnins.2022.919272
关键词[WOS]	VOXEL-BASED MORPHOMETRY ; AMYGDALA VOLUMES ; YOUNG-ADULTS ; ABNORMALITIES ; CONNECTIVITY ; ASSOCIATION ; INVENTORY ; PATTERNS ; CHILDREN ; COMMON
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000815676000001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/49208
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Song, Jinggui; Lv, Luxian
作者单位	1.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang, Peoples R China 2.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China 3.Int Joint Res Lab Psychiat & Neurosci Henan, Xinxiang, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Xinxiang Med Univ, Clin Coll 2, Dept Psychiat, Xinxiang, Peoples R China
推荐引用方式 GB/T 7714	Yang, Yongfeng,Li, Xue,Cui, Yue,et al. Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study[J]. FRONTIERS IN NEUROSCIENCE,2022,16:8.
APA	Yang, Yongfeng.,Li, Xue.,Cui, Yue.,Liu, Kang.,Qu, Haoyang.,...&Lv, Luxian.(2022).Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study.FRONTIERS IN NEUROSCIENCE,16,8.
MLA	Yang, Yongfeng,et al."Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study".FRONTIERS IN NEUROSCIENCE 16(2022):8.