Peptide-Conjugated Aggregation-Induced Emission Fluorogenic Probe for Glypican-3 Protein Detection and Hepatocellular Carcinoma Cells Imaging
Zhang, Song1; Jing, Jiangbo1; Meng, Lingchen1; Xu, Bin1; Ma, Xibo2,3,4; Tian, Wenjing1
发表期刊CHEMOSENSORS
2022-05-01
卷号10期号:5页码:10
通讯作者Ma, Xibo(xibo.ma@ia.ac.cn) ; Tian, Wenjing(wjtian@jlu.edu.cn)
摘要Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality on a global scale, and the development of accurate detection and imaging methods for HCC cells is urgently needed. Herein, by connecting peptide L5, which can specifically bind to the overexpressed Glypican-3 (GPC-3) protein of HCC cells with aggregation-induced emission (AIE) moiety ammonium cation-functionalized 9,10-distyrylanthracene (NDSA) via the "click" reaction, we synthesized a fluorescent probe NDSA-L5. In an aqueous solution, the probe shows weak emission, whereas, in the presence of the GPC-3 protein, bright fluorescence can be obtained since NDSA-L5 binds to the GPC-3 protein, leading to the restricted intramolecular movement of AIE-active NDSA-L5. The imaging and flow cytometry experiments demonstrate that the NDSA-L5 probe can rapidly accumulate in the subcutaneous HCC cells and liver tumor tissue and shows a potential application in early detection and surgical navigation for HCC cancer.
关键词hepatocellular carcinoma (HCC) Glypican-3 aggregation-induced emission (AIE) cells imaging
DOI10.3390/chemosensors10050195
关键词[WOS]PHOTODYNAMIC THERAPY ; LIVER-CANCER ; LABEL-FREE
收录类别SCI
语种英语
资助项目Natural Science Foundation of China[21835001] ; Natural Science Foundation of China[52073116] ; Natural Science Foundation of China[51773080] ; Natural Science Foundation of China[82090051] ; Natural Science Foundation of China[81871442] ; JLU Science and Technology Innovative Research Team[2021TD-03] ; National Key Research programs of China[2016YFA0100900] ; National Key Research programs of China[2016YFA0100902] ; Youth Innovation Promotion Association CAS[Y201930]
项目资助者Natural Science Foundation of China ; JLU Science and Technology Innovative Research Team ; National Key Research programs of China ; Youth Innovation Promotion Association CAS
WOS研究方向Chemistry ; Electrochemistry ; Instruments & Instrumentation
WOS类目Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS记录号WOS:000801364700001
出版者MDPI
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/49540
专题模式识别国家重点实验室_生物识别与安全技术
通讯作者Ma, Xibo; Tian, Wenjing
作者单位1.Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China
2.Chinese Acad Sci, Inst Automat, CBSR, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Automat, NLPR, Beijing 100049, Peoples R China
4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China
通讯作者单位中国科学院自动化研究所;  模式识别国家重点实验室
推荐引用方式
GB/T 7714
Zhang, Song,Jing, Jiangbo,Meng, Lingchen,et al. Peptide-Conjugated Aggregation-Induced Emission Fluorogenic Probe for Glypican-3 Protein Detection and Hepatocellular Carcinoma Cells Imaging[J]. CHEMOSENSORS,2022,10(5):10.
APA Zhang, Song,Jing, Jiangbo,Meng, Lingchen,Xu, Bin,Ma, Xibo,&Tian, Wenjing.(2022).Peptide-Conjugated Aggregation-Induced Emission Fluorogenic Probe for Glypican-3 Protein Detection and Hepatocellular Carcinoma Cells Imaging.CHEMOSENSORS,10(5),10.
MLA Zhang, Song,et al."Peptide-Conjugated Aggregation-Induced Emission Fluorogenic Probe for Glypican-3 Protein Detection and Hepatocellular Carcinoma Cells Imaging".CHEMOSENSORS 10.5(2022):10.
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