A novel co-targeting strategy of EGFR/SEC61G for multi-modality fluorescence/MR/photoacoustic imaging of glioblastoma

doi:10.1016/j.nano.2021.102509

	A novel co-targeting strategy of EGFR/SEC61G for multi-modality fluorescence/MR/photoacoustic imaging of glioblastoma
	Huang, Qi 1,2,4; Wang, Kun2 ; Wanggou, Siyi 1,4; Tian, Jie 2,3; Li, Xuejun 1,4
发表期刊	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
ISSN	1549-9634
	2022-02-01
卷号	40 页码:11
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Li, Xuejun(lxjneuro@csu.edu.cn)
摘要	Surgical resection is often the first choice and cornerstone therapy of glioblastoma; the degree of complete resection, as an important prognostic factor, is directly related to individuals' long-term outcomes. However, current imaging approaches, subjected to its single function and poor targeting affinity, used to have disappointing performance on preoperative diagnosis and intraoperative positioning. Herein, we have designed a nanoparticle for triple-modality NIF/MR/photoacoustic imaging and brought in a dual-targeting strategy with co expressed EGFR and SEC61G in glioblastoma. In comparison with the dual-negative nanocarrier, the EGFR/SEC61G biotargeting nanoprobe presented a significantly enhanced contrast and durability in vivo. Furthermore, we have evaluated the safety and biocompatibility using a CCK-8 assay ex vivo, which showed negligible toxicity. Therefore, the dual-target probes hold great potentials for a comprehensive preoperative plan and durable intraoperative navigation in glioblastoma.(c) 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).
关键词	Glioblastoma Multi-modality Molecular imaging Dual-target Theranostic
DOI	10.1016/j.nano.2021.102509
关键词[WOS]	CENTRAL-NERVOUS-SYSTEM ; 5-AMINOLEVULINIC ACID ; BRAIN ; RESECTION ; GLIOMA ; NANOPARTICLES ; EXTENT ; GENE ; ENDOCYTOSIS ; DELIVERY
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81770781] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[8193053] ; Key Research and Development Program of Hunan Province, China[2020SK2062] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Chinese Academy of Sciences[YJKYYQ20180048] ; Special funds for innovition in Hunan Province[2020SK2062] ; Science Foundation of Hunan Province, China[2019JJ50978] ; Xiangya big data platform
项目资助者	National Natural Science Foundation of China ; Key Research and Development Program of Hunan Province, China ; Chinese Academy of Sciences ; Special funds for innovition in Hunan Province ; Science Foundation of Hunan Province, China ; Xiangya big data platform
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
WOS类目	Nanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS记录号	WOS:000806835000004
出版者	ELSEVIER
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/49633
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Li, Xuejun
作者单位	1.Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China 3.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China 4.Cent South Univ, Xiangya Hosp, Hunan Int Sci & Technol Cooperat Base Brain Tumor, Changsha, Hunan, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Huang, Qi,Wang, Kun,Wanggou, Siyi,et al. A novel co-targeting strategy of EGFR/SEC61G for multi-modality fluorescence/MR/photoacoustic imaging of glioblastoma[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2022,40:11.
APA	Huang, Qi,Wang, Kun,Wanggou, Siyi,Tian, Jie,&Li, Xuejun.(2022).A novel co-targeting strategy of EGFR/SEC61G for multi-modality fluorescence/MR/photoacoustic imaging of glioblastoma.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,40,11.
MLA	Huang, Qi,et al."A novel co-targeting strategy of EGFR/SEC61G for multi-modality fluorescence/MR/photoacoustic imaging of glioblastoma".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 40(2022):11.