Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents

doi:10.1017/S0033291720002962

	Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents
	Li, Jin1,2 ; Liu, Bing1,2,3,4 ; Banaschewski, Tobias 5; Bokde, Arun L. W.6,7; Quinlan, Erin Burke 8; Desrivieres, Sylvane 8; Flor, Herta 9,10; Frouin, Vincent 11; Garavan, Hugh 12,13; Gowland, Penny 14; Heinz, Andreas 15,16,17,18; Ittermann, Bernd 19,20; Martinot, Jean-Luc 21,22; Artiges, Eric 21,23; Nees, Frauke 5,9; Orfanos, Dimitri Papadopoulos 11; Paus, Tomas 24,25,26; Poustka, Luise 27; Hohmann, Sarah 5; Froehner, Juliane H.28,29; Smolka, Michael N.28,29; Walter, Henrik 15,16,17,18; Whelan, Robert 30,31; Schumann, Gunter 8,32,33,34; Jiang, Tianzi1,2,3,4,35
发表期刊	PSYCHOLOGICAL MEDICINE
ISSN	0033-2917
	2022-04-01
卷号	52 期号:6 页码:1175-1182
通讯作者	Schumann, Gunter(gunter.schumann@kcl.ac.uk) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
摘要	Background Tobacco smoking remains one of the leading causes of preventable illness and death and is heritable with complex underpinnings. Converging evidence suggests a contribution of the polygenic risk for smoking to the use of tobacco and other substances. Yet, the underlying brain mechanisms between the genetic risk and tobacco smoking remain poorly understood. Methods Genomic, neuroimaging, and self-report data were acquired from a large cohort of adolescents from the IMAGEN study (a European multicenter study). Polygenic risk scores (PGRS) for smoking were calculated based on a genome-wide association study meta-analysis conducted by the Tobacco and Genetics Consortium. We examined the interrelationships among the genetic risk for smoking initiation, brain structure, and the number of occasions of tobacco use. Results A higher smoking PGRS was significantly associated with both an increased number of occasions of tobacco use and smaller cortical volume of the right orbitofrontal cortex (OFC). Furthermore, reduced cortical volume within this cluster correlated with greater tobacco use. A subsequent path analysis suggested that the cortical volume within this cluster partially mediated the association between the genetic risk for smoking and the number of occasions of tobacco use. Conclusions Our data provide the first evidence for the involvement of the OFC in the relationship between smoking PGRS and tobacco use. Future studies of the molecular mechanisms underlying tobacco smoking should consider the mediation effect of the related neural structure.
关键词	Cortical volume orbitofrontal cortex polygenic risk score smoking tobacco use
DOI	10.1017/S0033291720002962
关键词[WOS]	VENTROMEDIAL PREFRONTAL CORTEX ; SELF-REPORTED SMOKING ; CIGARETTE-SMOKING ; PRENATAL-EXPOSURE ; DECISION-MAKING ; METAANALYSIS ; NICOTINE ; IMPULSIVENESS ; ASSOCIATION ; VALIDATION
收录类别	SCI
语种	英语
资助项目	National Key Basic Research and Development Program (973)[2011CB707800] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02030300] ; Natural Science Foundation of China[81000582] ; Natural Science Foundation of China[31300934] ; Natural Science Foundation of China[91132301] ; Natural Science Foundation of China[91232718] ; European Union[LSHM-CT-2007-037286] ; Horizon 2020[695313] ; ERANID (Understanding the Interplay between Cultural, Biological, and Subjective Factors in Drug Use Pathways)[PR-ST-041610004] ; BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics)[MR/N027558/1] ; Human Brain Project (HBP SGA 2)[785907] ; FP7 project MATRICS[603016] ; Medical Research Council Grant 'c-VEDA' (Consortium on Vulnerability to Externalizing Disorders and Addictions)[MR/N000390/1] ; National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London ; Bundesministeriumfur Bildung und Forschung (BMBF)[01GS08152] ; Bundesministeriumfur Bildung und Forschung (BMBF)[01EV0711] ; Bundesministeriumfur Bildung und Forschung (BMBF)[01EE1406A] ; Bundesministeriumfur Bildung und Forschung (BMBF)[01EE1406B] ; Deutsche Forschungsgemeinschaft (DFG)[SM 80/7-2] ; Deutsche Forschungsgemeinschaft (DFG)[SFB 940] ; Deutsche Forschungsgemeinschaft (DFG)[TRR 265] ; Deutsche Forschungsgemeinschaft (DFG)[NE 1383/14-1] ; Medical Research Foundation ; Medical Research Council[MR/R00465X/1] ; Medical Research Council[MR/S020306/1] ; National Institutes of Health (NIH)[5U54EB020403-05] ; National Institutes of Health (NIH)[1R56AG058854-01] ; ANR[AF12-NEUR0008-01 -WM2NA] ; ANR[ANR-12-SAMA-0004] ; Eranet Neuron[ANR-18-NEUR00002-01] ; Fondation de France[00081242] ; Fondation pour la Recherche Medicale[DPA20140629802] ; Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA) ; Assistance-Publique-Hopitaux-de-Paris ; INSERM (interface grant) ; Paris Sud University IDEX 2012 ; fondation de l'Avenir[AP-RM-17-013] ; Federation pour la Recherche sur le Cerveau ; National Institutes of Health ; Science Foundation Ireland[16/ERCD/3797] ; U.S.A. (Axon, Testosterone and Mental Health during Adolescence)[RO1 MH085772-01A1] ; NIH Consortium grant - cross-NIH alliance[U54 EB020403]
项目资助者	National Key Basic Research and Development Program (973) ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Natural Science Foundation of China ; European Union ; Horizon 2020 ; ERANID (Understanding the Interplay between Cultural, Biological, and Subjective Factors in Drug Use Pathways) ; BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics) ; Human Brain Project (HBP SGA 2) ; FP7 project MATRICS ; Medical Research Council Grant 'c-VEDA' (Consortium on Vulnerability to Externalizing Disorders and Addictions) ; National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London ; Bundesministeriumfur Bildung und Forschung (BMBF) ; Deutsche Forschungsgemeinschaft (DFG) ; Medical Research Foundation ; Medical Research Council ; National Institutes of Health (NIH) ; ANR ; Eranet Neuron ; Fondation de France ; Fondation pour la Recherche Medicale ; Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA) ; Assistance-Publique-Hopitaux-de-Paris ; INSERM (interface grant) ; Paris Sud University IDEX 2012 ; fondation de l'Avenir ; Federation pour la Recherche sur le Cerveau ; National Institutes of Health ; Science Foundation Ireland ; U.S.A. (Axon, Testosterone and Mental Health during Adolescence) ; NIH Consortium grant - cross-NIH alliance
WOS研究方向	Psychology ; Psychiatry
WOS类目	Psychology, Clinical ; Psychiatry ; Psychology
WOS记录号	WOS:000849361300020
出版者	CAMBRIDGE UNIV PRESS
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/50018
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Schumann, Gunter; Jiang, Tianzi
作者单位	1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, 95 East Zhongguancun Rd, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, 95 East Zhongguancun Rd, Beijing 100190, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, 95 East Zhongguancun Rd, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 5.Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, Sq J5, D-68159 Mannheim, Germany 6.Trinity Coll Dublin, Sch Med, Discipline Psychiat, Dublin, Ireland 7.Trinity Coll Dublin, Trinity Coll Inst Neurosci, Dublin, Ireland 8.Kings Coll London, Ctr Populat Neurosci & Precis Med PONS, SGDP Ctr, Inst Psychiat Psychol & Neurosci, London, England 9.Heidelberg Univ, Med Fac Mannheim, Inst Cognit & Clin Neurosci, Cent Inst Mental Hlth, Sq J5, Mannheim, Germany 10.Univ Mannheim, Sch Social Sci, Dept Psychol, D-68131 Mannheim, Germany 11.Univ Paris Saclay, CEA, NeuroSpin, F-91191 Gif Sur Yvette, France 12.Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA 13.Univ Vermont, Dept Psychol, Burlington, VT 05405 USA 14.Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Univ Pk, Nottingham, England 15.Charite Univ Med Berlin, Dept Psychiat & Psychotherapy CCM, Berlin, Germany 16.Free Univ Berlin, Berlin, Germany 17.Humboldt Univ, Berlin, Germany 18.Berlin Inst Hlth, Berlin, Germany 19.Phys Tech Bundesanstalt PTB, Braunschweig, Germany 20.Phys Tech Bundesanstalt PTB, Benin, Germany 21.Univ Paris Saclay, INSERM, Unit Neuroimaging & Psychiat 1000, Univ Paris Descartes,Sorbonne Paris Cite, Paris, France 22.Maison Solenn, Paris, France 23.Orsay Hosp, Psychiat Dept 91G16, Orsay, France 24.Holland Bloorview Kids Rehabil Hosp, Bloorview Res Inst, Toronto, ON, Canada 25.Univ Toronto, Dept Psychol, Toronto, ON M6A 2E1, Canada 26.Univ Toronto, Dept Psychiat, Toronto, ON M6A 2E1, Canada 27.Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, von Siebold Str 5, D-37075 Gottingen, Germany 28.Tech Univ Dresden, Dept Psychiat, Dresden, Germany 29.Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany 30.Trinity Coll Dublin, Sch Psychol, Dublin, Ireland 31.Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland 32.Humboldt Univ, Dept Psychiat & Psychotherapy, PONS Res Grp, Campus Charite Mitte, Berlin, Germany 33.Leibniz Inst Neurobiol, Magdeburg, Germany 34.Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence IS, Shanghai, Peoples R China 35.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
第一作者单位	模式识别国家重点实验室
通讯作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Li, Jin,Liu, Bing,Banaschewski, Tobias,et al. Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents[J]. PSYCHOLOGICAL MEDICINE,2022,52(6):1175-1182.
APA	Li, Jin.,Liu, Bing.,Banaschewski, Tobias.,Bokde, Arun L. W..,Quinlan, Erin Burke.,...&Jiang, Tianzi.(2022).Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents.PSYCHOLOGICAL MEDICINE,52(6),1175-1182.
MLA	Li, Jin,et al."Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents".PSYCHOLOGICAL MEDICINE 52.6(2022):1175-1182.