Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells

doi:10.3390/bios12090703

	Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells
	Jia, Xiaohua1,2 ; Shen, Guodong 3,4; Jia, Jia 5; Zhang, Yan 2; Zhang, Dan6 ; Li, Wanjun 7; Zhang, Jianjun 8; Huang, Xinglu 9; Tian, Jie 1,10
发表期刊	BIOSENSORS-BASEL
	2022-09-01
卷号	12 期号:9 页码:13
通讯作者	Huang, Xinglu(huangxinglu@nankai.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要	The cancer stem cells (CSC) are the roots of cancer. The CSC hypothesis may provide a model to explain the tumor cell heterogeneity. Understand the biological mechanism of CSC will help the early detection and cure of cancer. The discovery of the dynamic changes in CSC will be possible by the using of bio-engineering techniques-lineage tracing. However, it is difficult to obtain real-time, continuous, and dynamic live-imaging information using the traditional approaches that take snapshots of time points from different animals. The goal of molecular imaging is to monitor the in situ, continuous molecular changes of cells in vivo. Therefore, the most advanced bioengineering lineage tracing approach, while using a variety of molecular detection methods, will maximize the presentation of CSC. In this review, we first introduce the method of lineage tracing, and then introduce the various components of molecular images to dynamic detect the CSC. Finally, we analyze the current situation and look forward the future of CSC detection.
关键词	lineage tracing molecular imaging cancer stem cells
DOI	10.3390/bios12090703
关键词[WOS]	DOUBLE REPORTER ; GASTRIC-CANCER ; TUMOR ; IDENTIFICATION ; NANOPARTICLES ; EXPRESSION ; METASTASES ; COLON ; REGENERATION ; PROGENITOR
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2017YFA0700401] ; National Natural Science Foundation of China[U21A20386] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[31871111] ; National Natural Science Foundation of China[8190070112] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Key Research Program of Frontier Sciences[QYZDY-SSW-SMC013] ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program[19JCZDJC65300] ; CAS Key Laboratory of Mental Health[KLMH2020K02] ; Laboratory Innovation Fund of Tsinghua University[531001019] ; Laboratory Innovation Fund of Tsinghua University[100006029] ; Project of High-Level Talents Team Introduction in Zhuhai City, Zhuhai[HLHPTP20170]
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program ; CAS Key Laboratory of Mental Health ; Laboratory Innovation Fund of Tsinghua University ; Project of High-Level Talents Team Introduction in Zhuhai City, Zhuhai
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation
WOS类目	Chemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation
WOS记录号	WOS:000856314800001
出版者	MDPI
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/50132
专题	中国科学院分子影像重点实验室
通讯作者	Huang, Xinglu; Tian, Jie
作者单位	1.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 2.Gen Hosp Peoples Liberat Army, Dept Ultrasound, Beijing 100853, Peoples R China 3.Southern Med Univ, Nanfang Hosp, Dept Gen Surg, Guangzhou 510515, Peoples R China 4.Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Precis Med Gastrointestina, Guangzhou 510515, Peoples R China 5.Shanxi Med Univ, Fenyang Coll, Fenyang 032200, Peoples R China 6.Tsinghua Univ, Ctr Biomed Anal, Beijing 100084, Peoples R China 7.Xi An Jiao Tong Univ, Dept Pathol, Affiliated Hosp 3201, Hanzhong 723000, Peoples R China 8.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 9.Nankai Univ, Coll Life Sci, Key Lab Bioact Mat Minist Educ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China 10.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med & Engn, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Jia, Xiaohua,Shen, Guodong,Jia, Jia,et al. Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells[J]. BIOSENSORS-BASEL,2022,12(9):13.
APA	Jia, Xiaohua.,Shen, Guodong.,Jia, Jia.,Zhang, Yan.,Zhang, Dan.,...&Tian, Jie.(2022).Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells.BIOSENSORS-BASEL,12(9),13.
MLA	Jia, Xiaohua,et al."Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells".BIOSENSORS-BASEL 12.9(2022):13.