Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells

doi:10.3390/bios12090703

	Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells
	Jia, Xiaohua1,2 ; Shen, Guodong 3,4; Jia, Jia 5; Zhang, Yan 2; Zhang, Dan6 ; Li, Wanjun 7; Zhang, Jianjun 8; Huang, Xinglu 9; Tian, Jie1,10
Source Publication	BIOSENSORS-BASEL
	2022-09-01
Volume	12 Issue:9 Pages:13
Corresponding Author	Huang, Xinglu(huangxinglu@nankai.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
Abstract	The cancer stem cells (CSC) are the roots of cancer. The CSC hypothesis may provide a model to explain the tumor cell heterogeneity. Understand the biological mechanism of CSC will help the early detection and cure of cancer. The discovery of the dynamic changes in CSC will be possible by the using of bio-engineering techniques-lineage tracing. However, it is difficult to obtain real-time, continuous, and dynamic live-imaging information using the traditional approaches that take snapshots of time points from different animals. The goal of molecular imaging is to monitor the in situ, continuous molecular changes of cells in vivo. Therefore, the most advanced bioengineering lineage tracing approach, while using a variety of molecular detection methods, will maximize the presentation of CSC. In this review, we first introduce the method of lineage tracing, and then introduce the various components of molecular images to dynamic detect the CSC. Finally, we analyze the current situation and look forward the future of CSC detection.
Keyword	lineage tracing molecular imaging cancer stem cells
DOI	10.3390/bios12090703
WOS Keyword	DOUBLE REPORTER ; GASTRIC-CANCER ; TUMOR ; IDENTIFICATION ; NANOPARTICLES ; EXPRESSION ; METASTASES ; COLON ; REGENERATION ; PROGENITOR
Indexed By	SCI
Language	英语
Funding Project	National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2017YFA0700401] ; National Natural Science Foundation of China[U21A20386] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[31871111] ; National Natural Science Foundation of China[8190070112] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Key Research Program of Frontier Sciences[QYZDY-SSW-SMC013] ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program[19JCZDJC65300] ; CAS Key Laboratory of Mental Health[KLMH2020K02] ; Laboratory Innovation Fund of Tsinghua University[531001019] ; Laboratory Innovation Fund of Tsinghua University[100006029] ; Project of High-Level Talents Team Introduction in Zhuhai City, Zhuhai[HLHPTP20170]
Funding Organization	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Key Research Program of Frontier Sciences ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program ; CAS Key Laboratory of Mental Health ; Laboratory Innovation Fund of Tsinghua University ; Project of High-Level Talents Team Introduction in Zhuhai City, Zhuhai
WOS Research Area	Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation
WOS Subject	Chemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation
WOS ID	WOS:000856314800001
Publisher	MDPI
Citation statistics	Cited Times:1[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.ia.ac.cn/handle/173211/50132
Collection	中国科学院分子影像重点实验室
Corresponding Author	Huang, Xinglu; Tian, Jie
Affiliation	1.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 2.Gen Hosp Peoples Liberat Army, Dept Ultrasound, Beijing 100853, Peoples R China 3.Southern Med Univ, Nanfang Hosp, Dept Gen Surg, Guangzhou 510515, Peoples R China 4.Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Precis Med Gastrointestina, Guangzhou 510515, Peoples R China 5.Shanxi Med Univ, Fenyang Coll, Fenyang 032200, Peoples R China 6.Tsinghua Univ, Ctr Biomed Anal, Beijing 100084, Peoples R China 7.Xi An Jiao Tong Univ, Dept Pathol, Affiliated Hosp 3201, Hanzhong 723000, Peoples R China 8.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 9.Nankai Univ, Coll Life Sci, Key Lab Bioact Mat Minist Educ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China 10.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med & Engn, Beijing 100191, Peoples R China
Recommended Citation GB/T 7714	Jia, Xiaohua,Shen, Guodong,Jia, Jia,et al. Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells[J]. BIOSENSORS-BASEL,2022,12(9):13.
APA	Jia, Xiaohua.,Shen, Guodong.,Jia, Jia.,Zhang, Yan.,Zhang, Dan.,...&Tian, Jie.(2022).Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells.BIOSENSORS-BASEL,12(9),13.
MLA	Jia, Xiaohua,et al."Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells".BIOSENSORS-BASEL 12.9(2022):13.

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