| Network localization of transient global amnesia beyond the hippocampus | |
Wang, Tao1,2; Xu, Yicheng3; Li, Deying4,5; Tu, Wenjun6; Li, Yanan1; Miao, Shuai1,2; Li, Jilai3; Wang, Peifu3; Zhao, Fei7 ; Fan, Lingzhong4,5,8; Yu, Shengyuan2
| |
| Source Publication | NEUROLOGICAL SCIENCES
 |
| ISSN | 1590-1874 |
| 2022-10-12 | |
| Pages | 9 |
| Corresponding Author | Fan, Lingzhong(lingzhong.fan@ia.ac.can) ; Yu, Shengyuan(yusy1963@126.com) |
| Abstract | Background Transient global amnesia is common in the older adult, but the cause and mechanism remain unclear. Focal brain lesions allow for causal links between the lesion location and resulting symptoms, and we based on the reported TGA-causing lesions and used lesion network mapping to explore the causal neuroanatomical substrate of TGA. Methods Fifty-one cases of transient global amnesias with DWI lesions from the literature were identified, and clinical data were extracted and analyzed. Next, we mapped each lesion volume onto a reference brain and computed the network of regions functionally connected to each lesion location using a large normative connectome dataset. Results Lesions primarily occurred in the hippocampus, and in addition to the hippocampus, there are also other locations of TGA-causing lesions such as the cingulate gyrus, anterior thalamic nucleus (ATN), putamen, caudate nucleus, corpus callosum, fornix. More than 90% of TGA-causing lesions inside the hippocampus were functionally connected with the default mode network (DMN). Conclusion Structural abnormality in the hippocampus was the most consistently reported in TGA, and besides the hippocampus, lesions occurring at several other brain locations also could cause TGA. The DMN may also be involved in the pathophysiology of TGA. According to the clinical and neuroimaging characteristics, TGA may be a syndrome with multiple causes and cannot be treated simply as a subtype of TIA. |
| Keyword | Transient global amnesia DMN Lesion network mapping |
| DOI | 10.1007/s10072-022-06439-4 |
| WOS Keyword | BASAL GANGLIA ; CONNECTIVITY ; ALZHEIMERS ; SYMPTOMS ; CORTEX ; RISK |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Neurosciences & Neurology |
| WOS Subject | Clinical Neurology ; Neurosciences |
| WOS ID | WOS:000866303100001 |
| Publisher | SPRINGER-VERLAG ITALIA SRL |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/50347 |
| Collection | 脑网络组研究 |
| Corresponding Author | Fan, Lingzhong; Yu, Shengyuan |
| Affiliation | 1.Med Sch Chinese PLA, Beijing 100853, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Neurol, Beijing 100853, Peoples R China 3.Aerosp Ctr Hosp, Dept Neurol, Beijing, Peoples R China 4.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 6.Chinese Acad Med Sci & Peking Union Med Coll, Beijing, Peoples R China 7.Aerosp Ctr Hosp, Dept Radiol, Beijing, Peoples R China 8.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China |
| Corresponding Author Affilication | Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Tao,Xu, Yicheng,Li, Deying,et al. Network localization of transient global amnesia beyond the hippocampus[J]. NEUROLOGICAL SCIENCES,2022:9. |
| APA | Wang, Tao.,Xu, Yicheng.,Li, Deying.,Tu, Wenjun.,Li, Yanan.,...&Yu, Shengyuan.(2022).Network localization of transient global amnesia beyond the hippocampus.NEUROLOGICAL SCIENCES,9. |
| MLA | Wang, Tao,et al."Network localization of transient global amnesia beyond the hippocampus".NEUROLOGICAL SCIENCES (2022):9. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment