CASIA OpenIR  > 脑图谱与类脑智能实验室  > 脑网络组研究
Network localization of transient global amnesia beyond the hippocampus
Wang, Tao1,2; Xu, Yicheng3; Li, Deying4,5; Tu, Wenjun6; Li, Yanan1; Miao, Shuai1,2; Li, Jilai3; Wang, Peifu3; Zhao, Fei7; Fan, Lingzhong4,5,8; Yu, Shengyuan2
Source PublicationNEUROLOGICAL SCIENCES
ISSN1590-1874
2022-10-12
Pages9
Corresponding AuthorFan, Lingzhong(lingzhong.fan@ia.ac.can) ; Yu, Shengyuan(yusy1963@126.com)
AbstractBackground Transient global amnesia is common in the older adult, but the cause and mechanism remain unclear. Focal brain lesions allow for causal links between the lesion location and resulting symptoms, and we based on the reported TGA-causing lesions and used lesion network mapping to explore the causal neuroanatomical substrate of TGA. Methods Fifty-one cases of transient global amnesias with DWI lesions from the literature were identified, and clinical data were extracted and analyzed. Next, we mapped each lesion volume onto a reference brain and computed the network of regions functionally connected to each lesion location using a large normative connectome dataset. Results Lesions primarily occurred in the hippocampus, and in addition to the hippocampus, there are also other locations of TGA-causing lesions such as the cingulate gyrus, anterior thalamic nucleus (ATN), putamen, caudate nucleus, corpus callosum, fornix. More than 90% of TGA-causing lesions inside the hippocampus were functionally connected with the default mode network (DMN). Conclusion Structural abnormality in the hippocampus was the most consistently reported in TGA, and besides the hippocampus, lesions occurring at several other brain locations also could cause TGA. The DMN may also be involved in the pathophysiology of TGA. According to the clinical and neuroimaging characteristics, TGA may be a syndrome with multiple causes and cannot be treated simply as a subtype of TIA.
KeywordTransient global amnesia DMN Lesion network mapping
DOI10.1007/s10072-022-06439-4
WOS KeywordBASAL GANGLIA ; CONNECTIVITY ; ALZHEIMERS ; SYMPTOMS ; CORTEX ; RISK
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:000866303100001
PublisherSPRINGER-VERLAG ITALIA SRL
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/50347
Collection脑图谱与类脑智能实验室_脑网络组研究
Corresponding AuthorFan, Lingzhong; Yu, Shengyuan
Affiliation1.Med Sch Chinese PLA, Beijing 100853, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Neurol, Beijing 100853, Peoples R China
3.Aerosp Ctr Hosp, Dept Neurol, Beijing, Peoples R China
4.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
6.Chinese Acad Med Sci & Peking Union Med Coll, Beijing, Peoples R China
7.Aerosp Ctr Hosp, Dept Radiol, Beijing, Peoples R China
8.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China
Corresponding Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Tao,Xu, Yicheng,Li, Deying,et al. Network localization of transient global amnesia beyond the hippocampus[J]. NEUROLOGICAL SCIENCES,2022:9.
APA Wang, Tao.,Xu, Yicheng.,Li, Deying.,Tu, Wenjun.,Li, Yanan.,...&Yu, Shengyuan.(2022).Network localization of transient global amnesia beyond the hippocampus.NEUROLOGICAL SCIENCES,9.
MLA Wang, Tao,et al."Network localization of transient global amnesia beyond the hippocampus".NEUROLOGICAL SCIENCES (2022):9.
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