CASIA OpenIR  > 中国科学院分子影像重点实验室
A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans
Wang, Jingbo1; Li, Siyi2; Wang, Kun3; Zhu, Ling1; Yang, Lin1; Zhu, Yunjing1; Zhang, Zhen2; Hu, Longwei2; Yuan, Yuan1; Fan, Qi1; Ren, Jiliang1; Yang, Gongxin1; Ding, Weilong1; Zhou, Xiaoyu4; Cui, Junqi5; Zhang, Chunye5; Yuan, Ying1; Huang, Ruimin4; Tian, Jie3; Tao, Xiaofeng1
Source PublicationANNALS OF SURGICAL ONCOLOGY
ISSN1068-9265
2022-10-02
Pages11
Corresponding AuthorYuan, Ying(yuany83@163.com) ; Huang, Ruimin(rmhuang@simm.ac.cn) ; Tian, Jie(tian@ieee.org) ; Tao, Xiaofeng(cjr.taoxiaofeng@vip.163.com)
AbstractIntroduction The postoperative survival of oral squamous cell carcinoma (SCC) relies on precise detection and complete resection of original tumors. The mucosal extension of the tumor is evaluated visually during surgery, but small and flat foci are difficult to detect. Real-time fluorescence imaging may improve detection of tumor margins. Materials and Methods In the current study, a peptide-based near-infrared (NIR) fluorescence dye, c-MET-binding peptide-indocyanine green (cMBP-ICG), which specifically targets tumor via c-MET binding, was synthetized. A prospective pilot clinical trial then was conducted with oral SCC patients and intraoperatively to assess the feasibility of cMBP-ICG used to detect tumors margins. Fluorescence was histologically correlated to determine sensitivity and specificity. Results The immunohistochemistry (IHC) results demonstrated increased c-Met expression in oral SCC compared with normal mucosa. Tumor-to-background ratios ranged from 2.71 +/- 0.7 to 3.11 +/- 1.2 in different concentration groups. From 10 patients with oral SCC, 60 specimens were collected from tumor margins. The sensitivity and specificity of discriminative value derived from cMBP-ICG application in humans were respectively 100% and 75%. Conclusions Topical application of cMBP-ICG is feasible and safe for optimizing intraoperative visualization and tumor margin detection in oral SCC patients, which could clinically increase the probability of complete resections and improve oncologic outcomes.
DOI10.1245/s10434-022-12532-x
WOS KeywordHEAD ; CANCER ; NANOPARTICLES ; OROPHARYNGEAL ; PROGRESSION ; EXPRESSION
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[91859202] ; National Natural Science Foundation of China[82172049] ; National Natural Science Foundation of China[91859106] ; National Natural Science Foundation of China[82172001]
Funding OrganizationNational Natural Science Foundation of China
WOS Research AreaOncology ; Surgery
WOS SubjectOncology ; Surgery
WOS IDWOS:000863965500002
PublisherSPRINGER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/50374
Collection中国科学院分子影像重点实验室
Corresponding AuthorYuan, Ying; Huang, Ruimin; Tian, Jie; Tao, Xiaofeng
Affiliation1.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Radiol, Shanghai, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Shanghai, Peoples R China
3.Chinese Acad Sci, Beijing Key Lab Mol Imaging, Inst Automat,State Key Lab Management & Control, CAS Key Lab Mol Imaging, Beijing, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Shanghai, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Pathol, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jingbo,Li, Siyi,Wang, Kun,et al. A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans[J]. ANNALS OF SURGICAL ONCOLOGY,2022:11.
APA Wang, Jingbo.,Li, Siyi.,Wang, Kun.,Zhu, Ling.,Yang, Lin.,...&Tao, Xiaofeng.(2022).A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans.ANNALS OF SURGICAL ONCOLOGY,11.
MLA Wang, Jingbo,et al."A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans".ANNALS OF SURGICAL ONCOLOGY (2022):11.
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