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Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications
Cheng, Zhongquan1,2; Ma, Jiaojiao3; Yin, Lin2,4; Yu, Leyi1; Yuan, Zhu1; Zhang, Bo3; Tian, Jie2,5; Du, Yang2,4
发表期刊EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
ISSN1619-7070
2022-11-29
页码23
通讯作者Yuan, Zhu(BJFH_yz_paper@163.com) ; Zhang, Bo(thyroidus@163.com) ; Tian, Jie(tian@ieee.org) ; Du, Yang(yang.du@ia.ac.cn)
摘要Lymph node metastasis is an indicator of the invasiveness and aggressiveness of cancer. It is a vital prognostic factor in clinical staging of the disease and therapeutic decision-making. Patients with positive metastatic lymph nodes are likely to develop recurrent disease, distant metastasis, and succumb to death in the coming few years. Lymph node dissection and histological analysis are needed to detect whether regional lymph nodes have been infiltrated by cancer cells and determine the likely outcome of treatment and the patient's chances of survival. However, these procedures are invasive, and tissue biopsies are prone to sampling error. In recent years, advanced molecular imaging with novel imaging probes has provided new technologies that are contributing to comprehensive management of cancer, including non-invasive investigation of lymphatic drainage from tumors, identifying metastatic lymph nodes, and guiding surgeons to operate efficiently in patients with complex lesions. In this review, first, we outline the current status of different molecular imaging modalities applied for lymph node metastasis management. Second, we summarize the multi-functional imaging probes applied with the different imaging modalities as well as applications of cancer lymph node metastasis from preclinical studies to clinical translations. Third, we describe the limitations that must be considered in the field of molecular imaging for improved detection of lymph node metastasis. Finally, we propose future directions for molecular imaging technology that will allow more personalized treatment plans for patients with lymph node metastasis.
关键词Molecular imaging Lymph node metastasis Cancer Imaging probes Imaging biomarkers
DOI10.1007/s00259-022-06056-5
关键词[WOS]EPITHELIAL-MESENCHYMAL TRANSITION ; SQUAMOUS-CELL CARCINOMA ; BREAST-CANCER ; INDOCYANINE GREEN ; EXTRACELLULAR VESICLES ; ADVERSE-REACTIONS ; TIM-3 EXPRESSION ; GUIDED SURGERY ; OVARIAN-CANCER ; FLUORESCENCE
收录类别SCI
语种英语
资助项目Beijing Natural Science Foundation[7212207] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81227901]
项目资助者Beijing Natural Science Foundation ; National Natural Science Foundation of China
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
WOS类目Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000889438400001
出版者SPRINGER
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/50834
专题中国科学院分子影像重点实验室
通讯作者Yuan, Zhu; Zhang, Bo; Tian, Jie; Du, Yang
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China
2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.China Japan Friendship Hosp, Dept Med Ultrason, Yinghua East Rd 2, Beijing 100029, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100080, Peoples R China
5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med Sci & Engn, Beijing 100191, Peoples R China
第一作者单位中国科学院分子影像重点实验室
通讯作者单位中国科学院分子影像重点实验室
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Cheng, Zhongquan,Ma, Jiaojiao,Yin, Lin,et al. Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2022:23.
APA Cheng, Zhongquan.,Ma, Jiaojiao.,Yin, Lin.,Yu, Leyi.,Yuan, Zhu.,...&Du, Yang.(2022).Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,23.
MLA Cheng, Zhongquan,et al."Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022):23.
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