A molecular probe carrying anti-tropomyosin 4 for early diagnosis of cerebral ischemia/reperfusion injury

doi:10.4103/1673-5374.357907

	A molecular probe carrying anti-tropomyosin 4 for early diagnosis of cerebral ischemia/reperfusion injury
	Yu, Teng-Fei 1; Wang, Kun2 ; Yin, Lu 1; Li, Wen-Zhe 3; Li, Chuan-Ping 4; Zhang, Wei1 ; Tian, Jie 2,5; He, Wen 1
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
	2023-06-01
卷号	18 期号:6 页码:1321-1324
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; He, Wen(hewen@bjtth.org)
摘要	In vivo imaging of cerebral ischemia/reperfusion injury remains an important challenge. We injected porous Ag/Au@SiO2 bimetallic hollow nanoshells carrying anti-tropomyosin 4 as a molecular probe into mice with cerebral ischemia/reperfusion injury and observed microvascular changes in the brain using photoacoustic imaging with ultrasonography. At each measured time point, the total photoacoustic signal was significantly higher on the affected side than on the healthy side. Twelve hours after reperfusion, cerebral perfusion on the affected side increased, cerebrovascular injury worsened, and anti-tropomyosin 4 expression increased. Twenty-four hours after reperfusion and later, perfusion on the affected side declined slowly and stabilized after 1 week; brain injury was also alleviated. Histopathological and immunohistochemical examinations confirmed the brain injury tissue changes. The nanoshell molecular probe carrying anti-tropomyosin 4 has potential for use in early diagnosis of cerebral ischemia/reperfusion injury and evaluating its progression.
关键词	cerebral ischemia/reperfusion injury diagnosis dynamic monitoring ischemic stroke middle cerebral artery occlusion molecular probe nanoshells photoacoustic imaging tropomyosin 4 ultrasound
DOI	10.4103/1673-5374.357907
关键词[WOS]	LIVING SUBJECTS ; TOMOGRAPHY ; EXPRESSION ; ISCHEMIA
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81730050]
项目资助者	National Natural Science Foundation of China
WOS研究方向	Cell Biology ; Neurosciences & Neurology
WOS类目	Cell Biology ; Neurosciences
WOS记录号	WOS:000894528300029
出版者	WOLTERS KLUWER MEDKNOW PUBLICATIONS
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/51010
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie; He, Wen
作者单位	1.Capital Med Univ, Beijing Tiantan Hosp, Dept Ultrasound, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China 3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China 4.Anhui Polytech Univ, Sch Chem & Environm Engn, Anhui Prov Key Lab Funct Coordinated Complexes Mat, Wuhu, Anhui Province, Peoples R China 5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Engn Med, Beijing, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Yu, Teng-Fei,Wang, Kun,Yin, Lu,et al. A molecular probe carrying anti-tropomyosin 4 for early diagnosis of cerebral ischemia/reperfusion injury[J]. NEURAL REGENERATION RESEARCH,2023,18(6):1321-1324.
APA	Yu, Teng-Fei.,Wang, Kun.,Yin, Lu.,Li, Wen-Zhe.,Li, Chuan-Ping.,...&He, Wen.(2023).A molecular probe carrying anti-tropomyosin 4 for early diagnosis of cerebral ischemia/reperfusion injury.NEURAL REGENERATION RESEARCH,18(6),1321-1324.
MLA	Yu, Teng-Fei,et al."A molecular probe carrying anti-tropomyosin 4 for early diagnosis of cerebral ischemia/reperfusion injury".NEURAL REGENERATION RESEARCH 18.6(2023):1321-1324.