Weighted sum of harmonic signals for direct imaging in magnetic particle imaging

doi:10.1088/1361-6560/aca9b9

	Weighted sum of harmonic signals for direct imaging in magnetic particle imaging
	Liu, Yanjun1,2,3,4,5 ; Hui, Hui4,5,6 ; Liu, Sijia 4,5,7; Li, Guanghui 1,2,3,4,5; Zhang, Bo 1,2,3,4,5; Zhong, Jing 8; An, Yu 1,2,3,4,5; Tian, Jie 1,2,3,4,5,7,9
发表期刊	PHYSICS IN MEDICINE AND BIOLOGY
ISSN	0031-9155
	2023-07-01
卷号	68 期号:1 页码:13
通讯作者	Hui, Hui(hui.hui@ia.ac.cn) ; Tian, Jie(tian@ieee.org)
摘要	Objective. Magnetic particle imaging (MPI) is a novel radiation-free medical imaging modality that can directly image superparamagnetic iron oxide tracers (SPIOs) with high sensitivity, temporal resolution, and good spatial resolution. The MPI reconstruction task can be formulated mathematically as a Fredholm integral problem, but the concrete inversion is not easily possible because of the particle dynamics or scanner issues. Measurement based system matrix inversion takes these factors into account, but prior measurement and calibration are time consuming. Approach. We proposed a direct imaging method based on the weighted sum of harmonic signals. The harmonic signals with spatial information are obtained by the short-time Fourier transform, and odd harmonic components are selected for recombination and then mapped to the sampling trajectory to image the concentration distribution of SPIOs. In addition, we adopt a normalized-weighted sum of harmonics to improve the resolution of the native image. Main results. The effectiveness of the proposed method is verified by simulation imaging experiments and our in-house scanner-based experiments. Quantitative evaluation results show that compared with traditional methods, the structural similarity improved by 48%, mean square error decreased by 88%, and signal-to-artifact ratio increased by 2.5 times. Significance. The proposed method can rapidly image the concentration distribution of nanoparticles without any prior calibration measurements and reduce the blur of MPI images without deconvolution, which has the potential to be implemented as a multi-patch imaging method in MPI.
关键词	magnetic particle imaging short-time fourier transform direct imaging multi-patch imaging
DOI	10.1088/1361-6560/aca9b9
关键词[WOS]	RECONSTRUCTION ; NANOPARTICLE ; PERFORMANCE ; AMPLITUDE ; TRACER ; MOTION
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFA0700401] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81827808] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81227901] ; CAS Youth Innovation Promotion Association[2018167] ; CAS Key Technology Talent Program ; Guangdong Key Research and Development Program of China[2021B0101420005] ; Project of High-Level Talents Team Introduction in Zhuhai City[Zhuhai HLHPTP201703]
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; CAS Youth Innovation Promotion Association ; CAS Key Technology Talent Program ; Guangdong Key Research and Development Program of China ; Project of High-Level Talents Team Introduction in Zhuhai City
WOS研究方向	Engineering ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000904747700001
出版者	IOP Publishing Ltd
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/51082
专题	中国科学院分子影像重点实验室
通讯作者	Hui, Hui; Tian, Jie
作者单位	1.Beihang Univ, Sch Engn Med, Beijing 100191, Peoples R China 2.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China 3.Beihang Univ, Key Lab Big Data Based Precis Med, Minist Ind & Informat Technol Peoples Republ China, Beijing 100191, Peoples R China 4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 5.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Southeast Univ, Sch Comp Sci & Engn, Nanjing 210096, Peoples R China 8.Beihang Univ, Sch Instrumentat & Optoelect Engn, Beijing 100191, Peoples R China 9.Jinan Univ, Zhuhai Peoples Hosp, Zhuhai Precis Med Ctr, Zhuhai 519000, Peoples R China
第一作者单位	中国科学院分子影像重点实验室
通讯作者单位	中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Liu, Yanjun,Hui, Hui,Liu, Sijia,et al. Weighted sum of harmonic signals for direct imaging in magnetic particle imaging[J]. PHYSICS IN MEDICINE AND BIOLOGY,2023,68(1):13.
APA	Liu, Yanjun.,Hui, Hui.,Liu, Sijia.,Li, Guanghui.,Zhang, Bo.,...&Tian, Jie.(2023).Weighted sum of harmonic signals for direct imaging in magnetic particle imaging.PHYSICS IN MEDICINE AND BIOLOGY,68(1),13.
MLA	Liu, Yanjun,et al."Weighted sum of harmonic signals for direct imaging in magnetic particle imaging".PHYSICS IN MEDICINE AND BIOLOGY 68.1(2023):13.