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Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder
Li, Xuemei1; Huang, Yang2; Liu, Mengqi2; Zhang, Manqi3,4; Liu, Yang2; Teng, Teng1; Liu, Xueer1; Yu, Ying5; Jiang, Yuanliang1; Ouyang, Xuan3,4; Xu, Ming6,7,8; Lv, Fajin2; Long, Yicheng3,4,9,10; Zhou, Xinyu1,11
Source PublicationINTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
ISSN1697-2600
2023-10-01
Volume23Issue:4Pages:9
Corresponding AuthorLong, Yicheng(yichenglong@csu.edu.cn) ; Zhou, Xinyu(zhouxinyu@cqmu.edu.cn)
AbstractChildhood trauma is a leading risk factor for adolescents developing major depressive disorder (MDD); however, the underlying neuroimaging mechanisms remain unclear. This study aimed to investigate the association among childhood trauma, MDD and brain dysfunctions by combining static and dynamic brain network models. We recruited 46 first-episode drug-naive adolescent MDD patients with childhood trauma (MDD-CT), 53 MDD patients without childhood trauma (MDD-nCT), and 90 healthy controls (HCs) for resting-state functional magnetic resonance imaging (fMRI) scans; all participants were aged 13-18 years. Compared to the HCs and MDD-nCT groups, the MDD-CT group exhibited significantly higher global and local efficiency in static brain networks and significantly higher temporal correlation coefficients in dynamic brain network models at the whole-brain level, and altered the local efficiency of default mode network (DMN) and temporal correlation coefficients of DMN, salience (SAN), and attention (ATN) networks at the local perspective. Correlation analysis indicated that altered brain network features and clinical symptoms, childhood trauma, and particularly emotional neglect were highly correlated in adolescents with MDD. This study may provide new evidence for the dysconnectivity hypothesis regarding the associations between childhood trauma and MDD in adolescents from the perspectives of both static and dynamic brain topology.
KeywordChildhood trauma Major depressive disorder Adolescent Functional neuroimaging Brain network
DOI10.1016/j.ijchp.2023.100401
WOS KeywordTEST-RETEST RELIABILITY ; DEFAULT-MODE NETWORK ; FUNCTIONAL CONNECTIVITY ; FMRI ; ORGANIZATION ; ARCHITECTURE ; METAANALYSIS ; ADVERSITIES ; ASSOCIATION ; RUMINATION
Indexed BySCI
Language英语
Funding ProjectSTI2030-Major Projects[82271565] ; National Natural Science Foundation of China[82201692] ; National Natural Science Foundation of China[cstc2020jcyj-jqX0024] ; Chongqing Outstanding Youth Foundation ; [2022ZD0212900]
Funding OrganizationSTI2030-Major Projects ; National Natural Science Foundation of China ; Chongqing Outstanding Youth Foundation
WOS Research AreaPsychology
WOS SubjectPsychology, Clinical
WOS IDWOS:001053489700001
PublisherELSEVIER SCIENCE INC
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/53946
Collection脑图谱与类脑智能实验室_脑网络组研究
Corresponding AuthorLong, Yicheng; Zhou, Xinyu
Affiliation1.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China
2.Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China
3.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Peoples R China
4.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Peoples R China
5.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
7.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
8.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
9.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, 139 Renmin Middle Rd, Changsha, Peoples R China
10.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, 139 Renmin Middle Rd, Changsha, Peoples R China
11.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, 1 Youyi Rd, Chongqing, Peoples R China
Recommended Citation
GB/T 7714
Li, Xuemei,Huang, Yang,Liu, Mengqi,et al. Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder[J]. INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,2023,23(4):9.
APA Li, Xuemei.,Huang, Yang.,Liu, Mengqi.,Zhang, Manqi.,Liu, Yang.,...&Zhou, Xinyu.(2023).Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder.INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY,23(4),9.
MLA Li, Xuemei,et al."Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder".INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY 23.4(2023):9.
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