Functional specialization and interaction in the amygdala-hippocampus circuit during working memory processing

doi:10.1038/s41467-023-38571-w

	Functional specialization and interaction in the amygdala-hippocampus circuit during working memory processing
	Li, Jin 1; Cao, Dan1 ; Yu, Shan1,2 ; Xiao, Xinyu 1,2; Imbach, Lukas 3,4,5; Stieglitz, Lennart 6; Sarnthein, Johannes 6,7; Jiang, Tianzi1,2,8
发表期刊	NATURE COMMUNICATIONS
	2023-05-22
卷号	14 期号:1 页码:11
通讯作者	Sarnthein, Johannes(johannes.sarnthein@usz.ch) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
摘要	Both the hippocampus and amygdala are involved in working memory (WM) processing. However, their specific role in WM is still an open question. Here, we simultaneously recorded intracranial EEG from the amygdala and hippo-campus of epilepsy patients while performing aWM task, and compared their representation patterns during the encoding and maintenance periods. By combining multivariate representational analysis and connectivity analyses with machine learning methods, our results revealed a functional specialization of the amygdala-hippocampal circuit: The mnemonic representations in the amygdala were highly distinct and decreased from encoding to maintenance. The hippocampal representations, however, weremore similar across different items but remained stable in the absence of the stimulus. WM encoding and maintenance were associated with bidirectional information flow between the amygdala and the hippocampus in low-frequency bands (1-40 Hz). Furthermore, the decoding accuracy on WM load was higher by using representational features in the amygdala during encoding and in the hippocampus during maintenance, and by using information flow from the amygdala during encoding and that from the hippocampus during maintenance, respectively. Taken together, our study reveals thatWMprocessing is associated with functional specialization and interaction within the amygdala-hippocampus circuit.
DOI	10.1038/s41467-023-38571-w
收录类别	SCI
语种	英语
资助项目	STI2030-Major Projects[2021ZD0200200] ; National Natural Science Foundation of China[32271085] ; National Natural Science Foundation of China[82151307] ; Science Frontier Program of the Chinese Academy of Sciences[XDBS01030200] ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning[CNLYB2004] ; Swiss National Science Foundation[SNSF 204651] ; Key Research Project of Zhejiang Lab[2022KI0AC02] ; Key Research Project of Zhejiang Lab[2022ND0AN01]
项目资助者	STI2030-Major Projects ; National Natural Science Foundation of China ; Science Frontier Program of the Chinese Academy of Sciences ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning ; Swiss National Science Foundation ; Key Research Project of Zhejiang Lab
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001024186000023
出版者	NATURE PORTFOLIO
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/53949
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Sarnthein, Johannes; Jiang, Tianzi
作者单位	1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 3.Klin Lengg, Swiss Epilepsy Ctr, Zurich, Switzerland 4.ETH, Zurich Neurosci Ctr, CH-8057 Zurich, Switzerland 5.Univ Zurich, CH-8057 Zurich, Switzerland 6.Univ Zurich, Univ Zurich Hosp, Dept Neurosurg, CH-8091 Zurich, Switzerland 7.Swiss Fed Inst Technol, Zurich Neurosci Ctr, CH-8057 Zurich, Switzerland 8.Zhejiang Lab, Res Ctr Augmented Intelligence, Hangzhou 311100, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Li, Jin,Cao, Dan,Yu, Shan,et al. Functional specialization and interaction in the amygdala-hippocampus circuit during working memory processing[J]. NATURE COMMUNICATIONS,2023,14(1):11.
APA	Li, Jin.,Cao, Dan.,Yu, Shan.,Xiao, Xinyu.,Imbach, Lukas.,...&Jiang, Tianzi.(2023).Functional specialization and interaction in the amygdala-hippocampus circuit during working memory processing.NATURE COMMUNICATIONS,14(1),11.
MLA	Li, Jin,et al."Functional specialization and interaction in the amygdala-hippocampus circuit during working memory processing".NATURE COMMUNICATIONS 14.1(2023):11.