Shank3 mutations enhance early neural responses to deviant tones in dogs

doi:10.1093/cercor/bhad302

CASIA OpenIR > 脑图谱与类脑智能实验室

	Shank3 mutations enhance early neural responses to deviant tones in dogs
	Wu, Liang 1,2; Mei, Shuting 3; Yu, Shan4,5 ; Han, Shihui 3; Zhang, Yong Q.1,2
发表期刊	CEREBRAL CORTEX
ISSN	1047-3211
	2023-08-16
页码	12
通讯作者	Han, Shihui(shan@pku.edu.cn) ; Zhang, Yong Q.(yqzhang@genetics.ac.cn)
摘要	Both enhanced discrimination of low-level features of auditory stimuli and mutations of SHANK3 (a gene that encodes a synaptic scaffolding protein) have been identified in autism spectrum disorder patients. However, experimental evidence regarding whether SHANK3 mutations lead to enhanced neural processing of low-level features of auditory stimuli is lacking. The present study investigated this possibility by examining effects of Shank3 mutations on early neural processing of pitch (tone frequency) in dogs. We recorded electrocorticograms from wild-type and Shank3 mutant dogs using an oddball paradigm in which deviant tones of different frequencies or probabilities were presented along with other tones in a repetitive stream (standards). We found that, relative to wild-type dogs, Shank3 mutant dogs exhibited larger amplitudes of early neural responses to deviant tones and greater sensitivity to variations of deviant frequencies within 100 ms after tone onsets. In addition, the enhanced early neural responses to deviant tones in Shank3 mutant dogs were observed independently of the probability of deviant tones. Our findings highlight an essential functional role of Shank3 in modulations of early neural detection of novel sounds and offer new insights into the genetic basis of the atypical auditory information processing in autism patients.
关键词	auditory processing autism dog electrocorticogram Shank3
DOI	10.1093/cercor/bhad302
关键词[WOS]	AUTISM SPECTRUM DISORDER ; MISMATCH NEGATIVITY ; DISCRIMINATION ; PROTEINS ; LATENCY ; BRAIN ; PROBABILITY ; INTEGRATION ; POTENTIALS ; MECHANISMS
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:001048345100001
出版者	OXFORD UNIV PRESS INC
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/53976
专题	脑图谱与类脑智能实验室
通讯作者	Han, Shihui; Zhang, Yong Q.
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 3.Peking Univ, McGovern Inst Brain Res, Sch Psychol & Cognit Sci, PKU IDG,Beijing Key Lab Behav & Mental Hlth, Beijing 100871, Peoples R China 4.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Automat, State Key Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wu, Liang,Mei, Shuting,Yu, Shan,et al. Shank3 mutations enhance early neural responses to deviant tones in dogs[J]. CEREBRAL CORTEX,2023:12.
APA	Wu, Liang,Mei, Shuting,Yu, Shan,Han, Shihui,&Zhang, Yong Q..(2023).Shank3 mutations enhance early neural responses to deviant tones in dogs.CEREBRAL CORTEX,12.
MLA	Wu, Liang,et al."Shank3 mutations enhance early neural responses to deviant tones in dogs".CEREBRAL CORTEX (2023):12.