CASIA OpenIR  > 脑图谱与类脑智能实验室  > 脑网络组研究
Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders
Long, Yicheng1,2; Li, Xuemei3; Cao, Hengyi4,5; Zhang, Manqi6; Lu, Bing7,8; Huang, Yang9; Liu, Mengqi9; Xu, Ming8,10,11; Liu, Zhening1,2; Yan, Chaogan7,8; Sui, Jing12; Ouyang, Xuan1,2; Zhou, Xinyu3
Source PublicationPSYCHOLOGICAL MEDICINE
ISSN0033-2917
2023-08-09
Pages10
Corresponding AuthorSui, Jing(jsui@bnu.edu.cn) ; Ouyang, Xuan(ouyangxuan@csu.edu.cn) ; Zhou, Xinyu(zhouxinyu@cqmu.edu.cn)
AbstractBackgroundThe age-related heterogeneity in major depressive disorder (MDD) has received significant attention. However, the neural mechanisms underlying such heterogeneity still need further investigation. This study aimed to explore the common and distinct functional brain abnormalities across different age groups of MDD patients from a large-sample, multicenter analysis. MethodsThe analyzed sample consisted of a total of 1238 individuals including 617 MDD patients (108 adolescents, 12-17 years old; 411 early-middle adults, 18-54 years old; and 98 late adults, > = 55 years old) and 621 demographically matched healthy controls (60 adolescents, 449 early-middle adults, and 112 late adults). MDD-related abnormalities in brain functional connectivity (FC) patterns were investigated in each age group separately and using the whole pooled sample, respectively. ResultsWe found shared FC reductions among the sensorimotor, visual, and auditory networks across all three age groups of MDD patients. Furthermore, adolescent patients uniquely exhibited increased sensorimotor-subcortical FC; early-middle adult patients uniquely exhibited decreased visual-subcortical FC; and late adult patients uniquely exhibited wide FC reductions within the subcortical, default-mode, cingulo-opercular, and attention networks. Analysis of covariance models using the whole pooled sample further revealed: (1) significant main effects of age group on FCs within most brain networks, suggesting that they are decreased with aging; and (2) a significant age group x MDD diagnosis interaction on FC within the default-mode network, which may be reflective of an accelerated aging-related decline in default-mode FCs. ConclusionsTo summarize, these findings may deepen our understanding of the age-related biological and clinical heterogeneity in MDD.
KeywordAging brain network connectome functional connectivity major depressive disorder
DOI10.1017/S0033291723002234
WOS KeywordDEFAULT-MODE NETWORK ; LATE-LIFE DEPRESSION ; OLDER-ADULTS ; CONNECTIVITY ; 1ST-EPISODE ; YOUNGER ; ONSET ; AGE
Indexed BySCI
Language英语
Funding ProjectSTI2030-Major Projects[2022ZD0212900] ; National Natural Science Foundation of China[82271565] ; National Natural Science Foundation of China[82201692] ; National Natural Science Foundation of China[82071506] ; Natural Science Foundation of Hunan Province, China[2021JJ40851]
Funding OrganizationSTI2030-Major Projects ; National Natural Science Foundation of China ; Natural Science Foundation of Hunan Province, China
WOS Research AreaPsychology ; Psychiatry
WOS SubjectPsychology, Clinical ; Psychiatry ; Psychology
WOS IDWOS:001044055700001
PublisherCAMBRIDGE UNIV PRESS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/53991
Collection脑图谱与类脑智能实验室_脑网络组研究
Corresponding AuthorSui, Jing; Ouyang, Xuan; Zhou, Xinyu
Affiliation1.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China
2.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China
3.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China
4.Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA
5.Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA
6.South China Normal Univ, Ctr Studies Psychol Applicat, Guangzhou, Peoples R China
7.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
8.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
9.Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China
10.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
11.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
12.Beijing Normal Univ, IDG McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Long, Yicheng,Li, Xuemei,Cao, Hengyi,et al. Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders[J]. PSYCHOLOGICAL MEDICINE,2023:10.
APA Long, Yicheng.,Li, Xuemei.,Cao, Hengyi.,Zhang, Manqi.,Lu, Bing.,...&Zhou, Xinyu.(2023).Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders.PSYCHOLOGICAL MEDICINE,10.
MLA Long, Yicheng,et al."Common and distinct functional brain network abnormalities in adolescent, early-middle adult, and late adult major depressive disorders".PSYCHOLOGICAL MEDICINE (2023):10.
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