State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex

doi:10.1016/j.brs.2023.07.049

	State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex
	Cao, Dan1 ; Liu, Qihong 2; Zhang, Jiaqi1,3 ; Li, Jin4 ; Jiang, Tianzi1,3,5
发表期刊	BRAIN STIMULATION
ISSN	1935-861X
	2023-07-01
卷号	16 期号:4 页码:1112-1122
通讯作者	Li, Jin(jli@nlpr.ia.ac.cn) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
摘要	Background: Orbitofrontal cortex (OFC) is a promising target for intracranial electrical stimulation (iES) aimed at improving mood states. However, knowledge gaps remain regarding the underlying neural mechanisms of iES effects, such as the effect of the OFC target in comparison with other emotional network targets, the impact of brain state at the time of stimulation, and the neural response induced by iES at both local and network scales. Objective: Our study aims to address the neural mechanisms underlying the effects of iES in improving mood states. Methods: We conducted a study in 24 epilepsy patients who received iES through implanted electrodes in the emotional network and compared the effects of iES on multiple targets in the emotional network. Results: We found that only iES applied to the orbitofrontal cortex (OFC) led to mood improvement and changes in neural activity. We also observed that iES to the OFC suppressed the delta-theta power when the brain was in a low mood state. Moreover, the iES to the OFC decreased delta-theta power and increased gamma power at local regions within the emotional network, and enhanced the information flow through the frequency domain among regions within the emotional network. Conclusions: These findings provide insight into the neural correlates of iES-induced mood improvement and support the potential of iES as a therapeutic intervention for mood disorders.
关键词	Intracranial electrical stimulation Orbitofrontal cortex State-specific modulation Emotional network Intracranial EEG
DOI	10.1016/j.brs.2023.07.049
关键词[WOS]	PROBABILISTIC FUNCTIONAL TRACTOGRAPHY ; CIRCUITS ; EMOTION ; REWARD
收录类别	SCI
语种	英语
资助项目	STI2030-Major Projects[32271085] ; National Natural Science Foundation of China[82151307] ; National Natural Science Foundation of China[CNLYB2004] ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning[2022KI0AC02] ; Key Research Project of Zhejiang Lab[2022ND0AN01] ; [2021ZD0200200]
项目资助者	STI2030-Major Projects ; National Natural Science Foundation of China ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning ; Key Research Project of Zhejiang Lab
WOS研究方向	Neurosciences & Neurology
WOS类目	Clinical Neurology ; Neurosciences
WOS记录号	WOS:001057252300001
出版者	ELSEVIER SCIENCE INC
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/54069
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Li, Jin; Jiang, Tianzi
作者单位	1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Peoples R China 3.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 4.Capital Normal Univ, Sch Psychol, Beijing 100048, Peoples R China 5.Zhejiang Lab, Res Ctr Augmented Intelligence, Hangzhou 311100, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Cao, Dan,Liu, Qihong,Zhang, Jiaqi,et al. State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex[J]. BRAIN STIMULATION,2023,16(4):1112-1122.
APA	Cao, Dan,Liu, Qihong,Zhang, Jiaqi,Li, Jin,&Jiang, Tianzi.(2023).State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex.BRAIN STIMULATION,16(4),1112-1122.
MLA	Cao, Dan,et al."State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex".BRAIN STIMULATION 16.4(2023):1112-1122.