CASIA OpenIR  > 中国科学院分子影像重点实验室
Detecting metastasis of gastric carcinoma using high-resolution micro-CT system: In vivo small animal study
Liu, Junting; Tian, Jie; Liang, Jimin; Li, Xiangsi; Yang, Xiang; Chen, Xiaofeng; Chen, Yi; Zhou, Yuanfeng; Wang, Xiaorui
2011
Conference NameProgress in Biomedical Optics and Imaging - SPIE
Source PublicationProgress in Biomedical Optics and Imaging - SPIE
Conference Date2011
Conference PlaceLake Buena Vista, Florida
AbstractImmunocytochemical and immunofluorescence staining are used for identifying the characteristics of metastasis intraditional ways. Micro-computed tomography (micro-CT) is a useful tool for monitoring and longitudinal imaging of tumor in small animal in vivo. In present study, we evaluated the feasibility of the detection for metastasis of gastric
carcinoma by high-resolution micro-CT system with omnipaque accumulative enhancement method in the organs.Firstly, a high-resolution micro-CT ZKKS-MCT-sharp micro-CT was developed by our research group and Guangzhou
Zhongke Kaisheng Medical Technology Co., Ltd. Secondly, several gastric carcinoma models were established through inoculating 2×106 BGC-823 gastric carcinoma cells subcutaneously. Thirdly, micro-CT scanning was performed after accumulative enhancement method of intraperitoneal injection of omnipaque contrast agent containing 360 mg iodine with a concentration of 350 mg I/ml. Finally, we obtained high-resolution anatomical information of the metastasis in vivo in a BALB/c NuNu nude mouse, the 3D tumor architecture is revealed in exquisite detail at about 35 μm spatial
resolution. In addition, the accurate shape and volume of the micrometastasis as small as 0.78 mm3 can be calculated with our software. Overall, our data suggest that this imaging approach and system could be used to enhance the understanding of tumor proliferation, metastasis and could be the basis for evaluating anti-tumor therapies.
KeywordMicro-ct Metastasis Gastric Carcinoma Detecting Contrast Enhancement
Indexed ByEI
Document Type会议论文
Identifierhttp://ir.ia.ac.cn/handle/173211/5425
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Recommended Citation
GB/T 7714
Liu, Junting,Tian, Jie,Liang, Jimin,et al. Detecting metastasis of gastric carcinoma using high-resolution micro-CT system: In vivo small animal study[C],2011.
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