CASIA OpenIR  > 中国科学院分子影像重点实验室
L1-regularized Cerenkov luminescence tomography with a SP 3 method and CT fusion
Zhong, Jianghong; Tian, Jie; Yang, Xin; Qin, Chenghu
2011
Conference Namethe Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Source PublicationAnnual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS)
Pages6158-6161
Conference Date2011
Conference PlaceItaly
AbstractAbstract— Imaging modality of radionuclides has been enriched by an optical approach, Cerenkov luminescence tomography (CLT). Referred to the traditional radionuclide imaging, such as positron emission tomography (PET) or single photon emission computed tomography (SPECT), any incremental improvement of CLT imaging is consistent with the application to information needs. In this contribution, the paper presents an l1-regularized imaging method for CLT problem. After utilizing the Vavilov-Cerenkov effect via third-order simplified spherical harmonics (SP3) approximation, we establish the large-scale linear equations in the CLT framework. The derived linear problem is seriously ill-posed, and transformed into an l1- regularized least squares program. The inverse solution to these equations is the three-dimensional radioisotope recovery data by an interior-point method. In the physical phantom and the in vivo mouse experiment, results demonstrate that the proposed technique produces better imaging quality and improves the reconstruction efficacy, compared with those from diffusion approximation with the Tikhonov regularization.
Keyword-
Indexed ByEI
Document Type会议论文
Identifierhttp://ir.ia.ac.cn/handle/173211/5434
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Recommended Citation
GB/T 7714
Zhong, Jianghong,Tian, Jie,Yang, Xin,et al. L1-regularized Cerenkov luminescence tomography with a SP 3 method and CT fusion[C],2011:6158-6161.
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