L1-regularized Cerenkov luminescence tomography with a SP 3 method and CT fusion

	L1-regularized Cerenkov luminescence tomography with a SP 3 method and CT fusion
	Zhong, Jianghong; Tian, Jie; Yang, Xin; Qin, Chenghu
	2011
会议名称	the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
会议录名称	Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS)
页码	6158-6161
会议日期	2011
会议地点	Italy
摘要	Abstract— Imaging modality of radionuclides has been enriched by an optical approach, Cerenkov luminescence tomography (CLT). Referred to the traditional radionuclide imaging, such as positron emission tomography (PET) or single photon emission computed tomography (SPECT), any incremental improvement of CLT imaging is consistent with the application to information needs. In this contribution, the paper presents an l1-regularized imaging method for CLT problem. After utilizing the Vavilov-Cerenkov effect via third-order simplified spherical harmonics (SP3) approximation, we establish the large-scale linear equations in the CLT framework. The derived linear problem is seriously ill-posed, and transformed into an l1- regularized least squares program. The inverse solution to these equations is the three-dimensional radioisotope recovery data by an interior-point method. In the physical phantom and the in vivo mouse experiment, results demonstrate that the proposed technique produces better imaging quality and improves the reconstruction efficacy, compared with those from diffusion approximation with the Tikhonov regularization.
关键词	-
收录类别	EI
文献类型	会议论文
条目标识符	http://ir.ia.ac.cn/handle/173211/5434
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
推荐引用方式 GB/T 7714	Zhong, Jianghong,Tian, Jie,Yang, Xin,et al. L1-regularized Cerenkov luminescence tomography with a SP 3 method and CT fusion[C],2011:6158-6161.

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