CASIA OpenIR  > 脑图谱与类脑智能实验室
Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness
Zhang, Haoran3,4; Zhuang, Yutong6; Dang, Yuanyuan5; Ge, Qianqian2; Yang, Yi2; Xu, Long2; Xia, Xiaoyu7; Laureys, Steven8,9,10; Yu, Shan3,4; Zhang, Wangming1,11
Source PublicationBRAIN STIMULATION
ISSN1935-861X
2023-09-01
Volume16Issue:5Pages:1522-1532
Corresponding AuthorYu, Shan(shan.yu@nlpr.ia.ac.cn) ; Zhang, Wangming(wzhang@vip.126.com)
AbstractBackground: Deep brain stimulation (DBS) in the centromedian-parafascicular complex (CM-pf) has been reported as a potential therapeutic option for disorders of consciousness (DoC). However, the lack of understanding of its electrophysiological characteristics limits the improvement of therapeutic effect. Objective: To investigate the CM-pf electrophysiological characteristics underlying disorders of consciousness (DoC) and its recovery. Methods: We collected the CM-pf electrophysiological signals from 23 DoC patients who underwent central thalamus DBS (CT-DBS) surgery. Five typical electrophysiological features were extracted, including neuronal firing properties, multiunit activity (MUA) properties, signal stability, spike-MUA synchronization strength (syncMUA), and the background noise level. Their correlations with the consciousness level, the outcome, and the primary clinical factors of DoC were analyzed. Results: 11 out of 23 patients (0/2 chronic coma, 5/13 unresponsive wakefulness syndrome/vegetative state (UWS/VS), 6/8 minimally conscious state minus (MCS-)) exhibited an improvement in the level of consciousness after CT-DBS. In CM-pf, significantly stronger gamma band syncMUA strength and alpha band normalized MUA power were found in MCS- patients. In addition, higher firing rates, stronger high-gamma band MUA power and alpha band normalized power, and more stable theta oscillation were correlated with better outcomes. Besides, we also identified electrophysiological properties that are correlated with clinical factors, including etiologies, age, and duration of DoC. Conclusion: We provide comprehensive analyses of the electrophysiological characteristics of CM-pf in DoC patients. Our results support the 'mesocircuit' hypothesis, one proposed mechanism of DoC recovery, and reveal CM-pf electrophysiological features that are crucial for understanding the pathogenesis of DoC, predicting its recovery, and explaining the effect of clinical factors on DoC.
KeywordDisorders of consciousness (DoC) Deep brain stimulation (DBS) Centromedian-parafascicular complex (CM-pf) Multiunit activity (MUA) Central thalamus (CT)
DOI10.1016/j.brs.2023.09.021
WOS KeywordDEEP BRAIN-STIMULATION ; ANTERIOR FOREBRAIN MESOCIRCUIT ; ALPHA-RHYTHM ; VEGETATIVE STATE ; THALAMIC-STIMULATION ; SUBTHALAMIC NUCLEUS ; AROUSAL REGULATION ; NEURONAL-ACTIVITY ; MULTIUNIT ; RECOVERY
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:001092799600001
PublisherELSEVIER SCIENCE INC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/54401
Collection脑图谱与类脑智能实验室
脑图谱与类脑智能实验室_脑机接口与融合智能
Corresponding AuthorYu, Shan; Zhang, Wangming
Affiliation1.Southern Med Univ, Zhujiang Hosp,Guangdong Prov Key Lab Brain Funct R, Neurosurg Inst Guangdong Prov,Minist China Diag &, Neurosurg Ctr,Engn Technol Res Ctr Educ,Natl Key C, Guangzhou, Peoples R China
2.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100070, Peoples R China
3.Chinese Acad Sci, Inst Automat, Lab Brain Atlas & Brain inspired Intelligence, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Neurosurg, Beijing 100853, Peoples R China
6.Southern Med Univ, Sch Clin Med 2, Dept Neurosurg, Guangzhou, Peoples R China
7.Peoples Liberat Army Gen Hosp, Med Ctr 7, Dept Neurosurg, Beijing 100700, Peoples R China
8.Laval Univ, CERVO Brain Res Ctr, Quebec City, PQ, Canada
9.Liege Univ Hosp, GIGA Consciousness Res Unit, Coma Sci Grp, Liege, Belgium
10.Hangzhou Normal Univ, Int Consciousness Sci Inst, Hangzhou, Zhejiang, Peoples R China
11.Southern Med Univ, Zhujiang Hosp, Neurosurg Inst Guangdong Prov,Guangdong Prov Key L, Neurosurg Ctr,Natl Key Clin Specialty,Engn Technol, Guangzhou 510282, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Haoran,Zhuang, Yutong,Dang, Yuanyuan,et al. Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness[J]. BRAIN STIMULATION,2023,16(5):1522-1532.
APA Zhang, Haoran.,Zhuang, Yutong.,Dang, Yuanyuan.,Ge, Qianqian.,Yang, Yi.,...&Zhang, Wangming.(2023).Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness.BRAIN STIMULATION,16(5),1522-1532.
MLA Zhang, Haoran,et al."Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness".BRAIN STIMULATION 16.5(2023):1522-1532.
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