Combination of time domain-system matrix and x-space methods to reconstruct magnetic particle images with isotropic resolution

doi:10.1088/1361-6560/ad19f0

	Combination of time domain-system matrix and x-space methods to reconstruct magnetic particle images with isotropic resolution
	Shan, Shihao 1; Zhang, Chenglong 1; Yin, Lin2 ; Yang, Xiaoli 1; Yu, Dexin 3; Qi, Yafei 3; Li, Min 4; Wildgruber, Moritz 5; Du, Yang2 ; Tian, Jie 2,6; Ma, Xiaopeng 1
发表期刊	PHYSICS IN MEDICINE AND BIOLOGY
ISSN	0031-9155
	2024-02-07
卷号	69 期号:3 页码:13
通讯作者	Du, Yang(yang.du@ia.ac.cn) ; Tian, Jie(tian@ieee.org) ; Ma, Xiaopeng(xiaopeng.ma@sdu.edu.cn)
摘要	Objective. Imaging of superparamagnetic iron oxide nanoparticles based on their non-linear response to alternating magnetic fields shows promise for imaging cells and vasculature in healthy and diseased tissue. Such imaging can be achieved through x-space reconstruction typically along a unidirectional Cartesian trajectory, which rapidly convolutes the particle distribution with a 'anisotropic blurring' point spread function (PSF), leading to images with anisotropic resolution. Approach. Here we propose combining the time domine-system matrix and x-space reconstruction methods into a forward model, where the output of the forward model is the PSF-blurred x-space reconstructed image. We then treat the blur as an inverse problem solved by Kaczmarz iteration. Main results. After we have proposed the method optimization, the normal resolution of simulation and device images has been increased from 3.5 mm and 5.25 mm to 1.5 mm and 3.25 mm, which has reached the level in the tangential resolution. Quantitative indicators of image quality such as PSNR and SSIM have also been greatly improved. Significance. Simulation and imaging of real phantoms indicate that our approach provides better isotropic resolution and image quality than the x-space method alone or other methods for removing PSF blur. Using our proposed method to optimize the image quality of x-space reconstructed images using unidirectional Cartesian trajectories, it will promote the clinical application of MPI in the future.
关键词	magnetic particle imaging x-space isotropic resolution time domain system matrix medical image reconstruction
DOI	10.1088/1361-6560/ad19f0
关键词[WOS]	MODEL
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China https://doi.org/10.13039/501100001809[2022CXGC010501] ; Key R&D Program of Shandong Province, China[82227802] ; National Natural Science Foundation of China
项目资助者	National Natural Science Foundation of China https://doi.org/10.13039/501100001809 ; Key R&D Program of Shandong Province, China ; National Natural Science Foundation of China
WOS研究方向	Engineering ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:001144946700001
出版者	IOP Publishing Ltd
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/54784
专题	中国科学院分子影像重点实验室
通讯作者	Du, Yang; Tian, Jie; Ma, Xiaopeng
作者单位	1.Shandong Univ, Sch Control Sci & Engn, Jinan 250061, Shandong, Peoples R China 2.Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Dept Radiol, Jinan 250012, Shandong, Peoples R China 4.960 Hosp PLA, Dept Nucl Med, 25 Shifan Rd, Jinan 250031, Shandong, Peoples R China 5.Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Radiol, D-81337 Munich, Germany 6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Engn Med, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Shan, Shihao,Zhang, Chenglong,Yin, Lin,et al. Combination of time domain-system matrix and x-space methods to reconstruct magnetic particle images with isotropic resolution[J]. PHYSICS IN MEDICINE AND BIOLOGY,2024,69(3):13.
APA	Shan, Shihao.,Zhang, Chenglong.,Yin, Lin.,Yang, Xiaoli.,Yu, Dexin.,...&Ma, Xiaopeng.(2024).Combination of time domain-system matrix and x-space methods to reconstruct magnetic particle images with isotropic resolution.PHYSICS IN MEDICINE AND BIOLOGY,69(3),13.
MLA	Shan, Shihao,et al."Combination of time domain-system matrix and x-space methods to reconstruct magnetic particle images with isotropic resolution".PHYSICS IN MEDICINE AND BIOLOGY 69.3(2024):13.