Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window

doi:10.1002/adhm.202302395

	Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window
	Ji, Yiming 1; Bai, Xue 3; Sun, Hongyan 1; Wang, Luyao 1; Gan, Chunyuan 1; Jia, Lina 1; Xu, Junjie 1; Zhang, Wei1 ; Wang, Liang5 ; Xu, Yingchen 6; Hou, Yaxin 7; Wang, Yinyan 8; Hui, Hui4 ; Feng, Lin 1,2
发表期刊	ADVANCED HEALTHCARE MATERIALS
ISSN	2192-2640
	2023-11-27
页码	12
通讯作者	Feng, Lin(linfeng@buaa.edu.cn)
摘要	Ferrofluidic robots with excellent deformability and controllability have been intensively studied recently. However, most of these studies are in vitro and the use of ferrofluids for in vivo medicinal applications remains a big challenge. The application of ferrofluidic robots to the body requires the solution of many key problems. In this study, biocompatibility, controllability, and tumor-killing efficacy are considered when creating a ferrofluid-based millirobot for in vivo tumor-targeted therapy. For biocompatibility problems, corn oil is used specifically for the ferrofluid robot. In addition, a control system is built that enables a 3D magnetic drive to be implemented in complex biological media. Using the photothermal conversion property of 1064 nm, the ferrofluid robot can kill tumor cells in vitro; inhibit tumor volume, destroy the tumor interstitium, increase tumor cell apoptosis, and inhibit tumor cell proliferation in vivo. This study provides a reference for ferrofluid-based millirobots to achieve targeted therapies in vivo. In this study, biocompatibility, controllability, and tumor-killing efficacy are considered when creating a ferrofluid-based cross-scale robot for tumor-targeted therapy. For biocompatibility, corn oil is used specifically as the base-liquid. Furthermore, the robot can move in complex biological media. Using photothermal property under a 1064 nm laser, a ferrofluid robot can inhibit tumor volume in vivo.image
关键词	ferrofluid robots biocompatibility targeted therapy
DOI	10.1002/adhm.202302395
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China ; Beijing Nova Program of Science and Technology[Z191100001119003] ; National Natural Science Foundation of China[52205584] ; [2019YFB1309700]
项目资助者	National Key R&D Program of China ; Beijing Nova Program of Science and Technology ; National Natural Science Foundation of China
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
WOS类目	Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS记录号	WOS:001108801900001
出版者	WILEY
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/55087
专题	中国科学院分子影像重点实验室
通讯作者	Feng, Lin
作者单位	1.Beihang Univ, Sch Mech Engn & Automat, Beijing 100191, Peoples R China 2.Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Beijing 100191, Peoples R China 3.Capital Med Univ, Sch Biomed Engn, Beijing 100069, Peoples R China 4.Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 5.Capital Med Univ, Beijing Tongren Hosp, Dept Hematol, Beijing 100730, Peoples R China 6.Capital Med Univ, Beijing Tongren Hosp, Dept Gen Surg, Beijing 100730, Peoples R China 7.Capital Med Univ, Beijing Tongren Hosp, Dept Diagnost Ultrasound, Beijing 100730, Peoples R China 8.Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Ji, Yiming,Bai, Xue,Sun, Hongyan,et al. Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window[J]. ADVANCED HEALTHCARE MATERIALS,2023:12.
APA	Ji, Yiming.,Bai, Xue.,Sun, Hongyan.,Wang, Luyao.,Gan, Chunyuan.,...&Feng, Lin.(2023).Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window.ADVANCED HEALTHCARE MATERIALS,12.
MLA	Ji, Yiming,et al."Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window".ADVANCED HEALTHCARE MATERIALS (2023):12.