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Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe3O4 Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy
Jin, Yushen1; Cheng, Zhongquan2; Yuan, Zhu2; Du, Yang3; Tian, Jie3; Shao, Bing1,4
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
2024
Volume19Pages:189-208
Corresponding AuthorShao, Bing(shaobingch@sina.com)
AbstractPurpose: Liver cancer is considered as the third leading cause of cancer-related deaths, with hepatocellular carcinoma (HCC) accounting for approximately 90% of liver cancers. Improving the treatment of HCC is a serious challenge today. The primary objective of this study was to construct SP94-Fe3O4@ICG&DOX nanoparticles and investigate their potential diagnosis and treatment effect benefits on HCC.Methods: Firstly, we synthesized and characterized SP94-Fe3O4@ICG&DOX nanoparticles and confirmed their in vitro release behavior, photothermal and photodynamic performance. Moreover, the in vivo imaging capability was also observed. Finally, the inhibitory effects on Hepa1-6 in vitro and in vivo were observed as well as biosafety.Results: SP94-Fe3O4@ICG&DOX nanoparticles have a size of similar to 22.1 nm, with an encapsulation efficiency of 45.2% for ICG and 42.7% for DOX, showing excellent in vivo MPI and fluorescence imaging capabilities for precise tumor localization, and synergistic photo-chemotherapy (pH-and thermal-sensitive drug release) against tumors under irradiation. With the assistance of a fluorescence molecular imaging system or MPI scanner, the location and contours of the tumor were clearly visible. Under a constant laser irradiation (808 nm, 0.6 W/cm2) and a set concentration (50 mu g/mL), the temperature of the solution could rapidly increase to similar to 45 C-degrees, which could effectively kill the tumor cells. It could be effectively uptaken by HCC cells and significantly inhibit their proliferation under the laser irradiation (100% inhibition rate for HCC tumors). And most importantly, our nanoparticles exhibited favorable biocompatibility with normal tissues and cells.Conclusion: This versatile agent can serve as an intelligent and promising nanoplatform that integrates multiple accurate diagnoses, precise positioning of cancer tissue, and effective coordination with synergistic tumor photodynamic therapy.
Keywordporous hollow structure magnetic particle imaging fluorescence imaging synergistic treatment theranostics
DOI10.2147/IJN.S428687
WOS KeywordCANCER ; PERFORMANCE ; DOXORUBICIN ; GRP78
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[82072098]
Funding OrganizationNational Natural Science Foundation of China
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS IDWOS:001145402800001
PublisherDOVE MEDICAL PRESS LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/55465
Collection中国科学院分子影像重点实验室
Corresponding AuthorShao, Bing
Affiliation1.Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China
2.Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China
3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China
Recommended Citation
GB/T 7714
Jin, Yushen,Cheng, Zhongquan,Yuan, Zhu,et al. Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe3O4 Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2024,19:189-208.
APA Jin, Yushen,Cheng, Zhongquan,Yuan, Zhu,Du, Yang,Tian, Jie,&Shao, Bing.(2024).Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe3O4 Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy.INTERNATIONAL JOURNAL OF NANOMEDICINE,19,189-208.
MLA Jin, Yushen,et al."Glucose-Regulated Protein 78 Targeting ICG and DOX Loaded Hollow Fe3O4 Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy".INTERNATIONAL JOURNAL OF NANOMEDICINE 19(2024):189-208.
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