CASIA OpenIR  > 脑图谱与类脑智能实验室  > 脑网络组研究
Macaque Brainnetome Atlas: A multifaceted brain map with parcellation, connection, and histology
Lu YH(陆玉恒)1,2; Cui Y(崔玥)1,3; Cao L(曹龙)4,6; Dong ZW(董振伟)1,2; Cheng LQ(程禄祺)1,9,11; Wu W(吴雯)11; Wang CS(王昌硕)1,3,10; Liu XY(刘新异)1,2,3; Liu YT(刘友通)1,2; Zhang BG(张宝贵)1,3; Li DY(李德莹)1,2; Zhao BK(赵舶凯)1,2; Wang HY(王海艳)1; Li KX(李开心)1; Ma L(马亮)1; Shi WY(时维阳)1; Li W(李雯)1; Hou XX(侯肖逍)1; Han JL(韩景路)1; Sun HJ(孙洪吉)1; Cai T(蔡涛)11; Peng Q(彭强)11; Feng LQ(冯琳清)11; Wang JJ(王骄健)7; George Paxinos5; Yang ZY(杨正宜)1,12; Fan LZ(樊令仲)1,2; Jiang TZ(蒋田仔)1,2,11,12
Source PublicationScience Bulletin
2024
Pages1
Abstract

The rhesus macaque (Macaca mulatta) is a crucial experimental animal that shares many genetic, brain organizational, and behavioral characteristics with humans. A macaque brain atlas is fundamental to biomedical and evolutionary research. However, even though connectivity is vital for understanding brain functions, a connectivity-based whole-brain atlas of the macaque has not previously been made. In this study, we created a new whole-brain map, the Macaque Brainnetome Atlas (MacBNA), based on the anatomical connectivity profiles provided by high angular and spatial resolution ex vivo diffusion MRI data. The new atlas consists of 248 cortical and 56 subcortical regions as well as their structural and functional connections. The parcellation and the diffusion-based tractography were evaluated with invasive neuronal-tracing and Nissl-stained images. As a demonstrative application, the structural connectivity divergence between macaque and human brains was mapped using the Brainnetome atlases of those two species to uncover the genetic underpinnings of the evolutionary changes in brain structure. The resulting resource includes: (1) the thoroughly delineated Macaque Brainnetome Atlas (MacBNA), (2) regional connectivity profiles, (3) the postmortem high-resolution macaque diffusion and T2-weighted MRI dataset (Brainnetome-8), and (4) multi-contrast MRI, neuronal-tracing, and histological images collected from a single macaque. MacBNA can serve as a common reference frame for mapping multifaceted features across modalities and spatial scales and for integrative investigation and characterization of brain organization and function. Therefore, it will enrich the collaborative resource platform for nonhuman primates and facilitate translational and comparative neuroscience research.

Sub direction classification脑网络分析
planning direction of the national heavy laboratory脑启发多模态智能模型与算法
Paper associated data
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/56573
Collection脑图谱与类脑智能实验室_脑网络组研究
Affiliation1.Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
2.School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing 100049, China
3.University of Chinese Academy of Sciences, Beijing 100049, China
4.University of Chinese Academy of Sciences, Beijing 100049, China
5.Neuroscience Research Australia and The University of New South Wales, Sydney NSW 2031, Australia
6.Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China
7.State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China
8.School of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbin 150080, China
9.School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China
10.Sino-Danish College, University of Chinese Academy of Science, Beijing 100049, China
11.Research Center for Augmented Intelligence, Zhejiang Lab, Hangzhou 311100, China
12.Xiaoxiang Institute for Brain Health and Yongzhou Central Hospital, Yongzhou 425000, China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Lu YH,Cui Y,Cao L,et al. Macaque Brainnetome Atlas: A multifaceted brain map with parcellation, connection, and histology[J]. Science Bulletin,2024:1.
APA Lu YH.,Cui Y.,Cao L.,Dong ZW.,Cheng LQ.,...&Jiang TZ.(2024).Macaque Brainnetome Atlas: A multifaceted brain map with parcellation, connection, and histology.Science Bulletin,1.
MLA Lu YH,et al."Macaque Brainnetome Atlas: A multifaceted brain map with parcellation, connection, and histology".Science Bulletin (2024):1.
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