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Aberrant brain functional and structural developments in MECP2 duplication rats | |
Xu, Ming1,2![]() ![]() ![]() ![]() ![]() | |
发表期刊 | Neurobiology of Disease
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2022-08-17 | |
卷号 | 173页码:105838 |
摘要 | Transgenic animal models with homologous etiology provide a promising way to pursue the neurobiological substrates of the behavioral deficits in autism spectrum disorder (ASD). Gain-of-function mutations of MECP2 cause MECP2 duplication syndrome, a severe neurological disorder with core symptoms of ASD. However, abnormal brain developments underlying the autistic-like behavioral deficits of MECP2 duplication syndrome are rarely investigated. To this end, a human MECP2 duplication (MECP2-DP) rat model was created by the bacterial artificial chromosome transgenic method. Functional and structural magnetic resonance imaging (MRI) with high-field were performed on 16 male MECP2-DP rats and 15 male wildtype rats at postnatal 28 days, 42 days, and 56 days old. Multimodal fusion analyses guided by locomotor-relevant metrics and social novelty time separately were applied to identify abnormal brain networks associated with diverse behavioral deficits induced by MECP2 duplication. Aberrant functional developments of a core network primarily composed of the dorsal medial prefrontal cortex (dmPFC) and retrosplenial cortex (RSP) were detected to associate with diverse behavioral phenotypes in MECP2-DP rats. Altered developments of gray matter volume were detected in the hippocampus and thalamus. We conclude that gain-of-function mutations of MECP2 induce aberrant functional activities in the default-mode-like network and aberrant volumetric changes in the brain, resulting in autistic-like behavioral deficits. Our results gain critical insights into the biomarker of MECP2 duplication syndrome and the neurobiological underpinnings of the behavioral deficits in ASD. |
是否为代表性论文 | 是 |
七大方向——子方向分类 | 脑网络分析 |
国重实验室规划方向分类 | 其他 |
是否有论文关联数据集需要存交 | 否 |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/56625 |
专题 | 脑图谱与类脑智能实验室_脑机接口与融合智能 |
通讯作者 | Liang, Zhifeng; Sui, Jing |
作者单位 | 1.Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences; Beijing, 100190, China 2.School of Artificial Intelligence, University of Chinese Academy of Sciences; Beijing, 100190, China 3.College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics; Nanjing, 211106, China 4.Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia Institute of Technology, Georgia State University, Emory University; Atlanta, GA 30303, USA 5.Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences; Shanghai, 200031, China 6.Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Peking University School of Life Sciences; Beijing, 100871, China 7.PKU-IDG/McGovern Institute for Brain Research, Peking-Tsinghua Center for Life Sciences; Beijing, 100871, China 8.Present address: Bruker BioSpin PCI; Shanghai, China 9.Present address: Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, MDP Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Brain Science and Brain Medicine; Hangzhou, 310058, China 10.IDG/McGovern Institute for Brain Research, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China |
第一作者单位 | 模式识别国家重点实验室 |
推荐引用方式 GB/T 7714 | Xu, Ming,Qi, Shile,Calhoun, Vince,et al. Aberrant brain functional and structural developments in MECP2 duplication rats[J]. Neurobiology of Disease,2022,173:105838. |
APA | Xu, Ming.,Qi, Shile.,Calhoun, Vince.,Dai, Jiankun.,Yu, Bin.,...&Sui, Jing.(2022).Aberrant brain functional and structural developments in MECP2 duplication rats.Neurobiology of Disease,173,105838. |
MLA | Xu, Ming,et al."Aberrant brain functional and structural developments in MECP2 duplication rats".Neurobiology of Disease 173(2022):105838. |
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2022_NBD_MXu_MECP2-r(3238KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 |
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