Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Elucidating Iron Metabolism through Molecular Imaging | |
Liao, Feifei1,2; Yang, Wenwen2,3; Long, Linzi2; Yu, Ruotong1,2; Qu, Hua2; Peng, Yuxuan1,2; Lu, Jieming1,2; Ren, Chenghuan1,2; Wang, Yueqi3; Fu, Changgeng2 | |
发表期刊 | CURRENT ISSUES IN MOLECULAR BIOLOGY |
ISSN | 1467-3037 |
2024-04-01 | |
卷号 | 46期号:4页码:2798-2818 |
摘要 | Iron is essential for many physiological processes, and the dysregulation of its metabolism is implicated in the pathogenesis of various diseases. Recent advances in iron metabolism research have revealed multiple complex pathways critical for maintaining iron homeostasis. Molecular imaging, an interdisciplinary imaging technique, has shown considerable promise in advancing research on iron metabolism. Here, we comprehensively review the multifaceted roles of iron at the cellular and systemic levels (along with the complex regulatory mechanisms of iron metabolism), elucidate appropriate imaging methods, and summarize their utility and fundamental principles in diagnosing and treating diseases related to iron metabolism. Utilizing molecular imaging technology to deeply understand the complexities of iron metabolism and its critical role in physiological and pathological processes offers new possibilities for early disease diagnosis, treatment monitoring, and the development of novel therapies. Despite technological limitations and the need to ensure the biological relevance and clinical applicability of imaging results, molecular imaging technology's potential to reveal the iron metabolic process is unparalleled, providing new insights into the link between iron metabolism abnormalities and various diseases. |
关键词 | iron metabolism molecular mechanism molecular imaging technology visualization iron homeostasis |
DOI | 10.3390/cimb46040175 |
关键词[WOS] | SICKLE-CELL-DISEASE ; NONINVASIVE MEASUREMENT ; LIVER ; RESONANCE ; OVERLOAD ; TRACKING ; BIODISTRIBUTION ; HOMEOSTASIS ; THALASSEMIA ; DEFICIENCY |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Science and Technology Innovation Project of China, Academy of Chinese Medical Sciences |
项目资助者 | Science and Technology Innovation Project of China, Academy of Chinese Medical Sciences |
WOS研究方向 | Biochemistry & Molecular Biology |
WOS类目 | Biochemistry & Molecular Biology |
WOS记录号 | WOS:001210760600001 |
出版者 | MDPI |
七大方向——子方向分类 | 图像视频处理与分析 |
国重实验室规划方向分类 | 其他 |
是否有论文关联数据集需要存交 | 否 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/57012 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Wang, Yueqi; Fu, Changgeng |
作者单位 | 1.Beijing Univ Chinese Med, Beijing Univ Tradit Chinese Med, Grad Sch, Beijing 100105, Peoples R China 2.China Acad Chinese Med Sci, Grad Sch, Beijing 100091, Peoples R China 3.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging,Inst Automat, Beijing 100190, Peoples R China |
通讯作者单位 | 中国科学院自动化研究所 |
推荐引用方式 GB/T 7714 | Liao, Feifei,Yang, Wenwen,Long, Linzi,et al. Elucidating Iron Metabolism through Molecular Imaging[J]. CURRENT ISSUES IN MOLECULAR BIOLOGY,2024,46(4):2798-2818. |
APA | Liao, Feifei.,Yang, Wenwen.,Long, Linzi.,Yu, Ruotong.,Qu, Hua.,...&Fu, Changgeng.(2024).Elucidating Iron Metabolism through Molecular Imaging.CURRENT ISSUES IN MOLECULAR BIOLOGY,46(4),2798-2818. |
MLA | Liao, Feifei,et al."Elucidating Iron Metabolism through Molecular Imaging".CURRENT ISSUES IN MOLECULAR BIOLOGY 46.4(2024):2798-2818. |
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