CASIA OpenIR  > 中国科学院分子影像重点实验室
Quantitative visualization of myocardial ischemia– reperfusion-induced cardiac lesions via ferroptosis magnetic particle imaging
Wenwen Yang1,2,3; Yueqi Wang3; Changgeng Fu1,2; Changjian Li4; Feng Feng5; Hongzheng Li1,2,6; Ling Tan1,2; Hua Qu1,2; Hui Hui3; Jingjing Wang3,7; Jie Tian3; Linzi Long1,2,8
Source PublicationTheranostics
2024
Volume14Issue:3Pages:1081-1097
Abstract
Myocardial ischemia-reperfusion (MI/R) injury is a complication in vascular reperfusion therapy for MI, occurring in approximately 60% of patients. Ferroptosis is an important process in the development of MI/R cardiac lesions. Transferrin receptor 1 (TfR1), a marker of ferroptosis, corresponds to the changes in MI/R cardiac lesions and is expected to be a biomarker for detecting MI/R-induced ferroptosis. However, the noninvasive in vivo visualization of ferroptosis in MI/R is a big challenge. Thus, this study aimed to develop a novel multimodal imaging platform to identify markers of MI/R cardiac lesions in vivo through targeting TfR1.
Methods: Magnetic particle imaging (MPI) modality for ferroptosis based on superparamagnetic cubic-iron oxide nanoparticles (SCIO NPs), named feMPI, has been developed. FeMPI used TfR1 as a typical biomarker. The feMPI probe (SCIO-ICG-CRT-CPPs NPs, CCI NPs) consists of SCIO NPs, TfR1-targeting peptides (CRT), cell-penetrating peptides (CPPs), and indocyanine green (ICG). The specificity and sensitivity of CCI NPs in the MI/R mouse model were evaluated by MPI, magnetic resonance imaging (MRI), and near-infrared (NIR) fluorescent imaging.
Results: The intensity of the MPI signal correlates linearly with the percentage of infarct area in MI/R stained by TTC, enabling a quantitative assessment of the extent of cardiac lesions. Notably, these findings are consistent with the standard clinical biochemical indicators in MI/R within the first 24 h. FeMPI detects cardiac injury approximately 48 h prior to the current clinical imaging detection methods of MI/R.
Conclusion: The feMPI strategy can be a powerful tool for studying the process of MI/R-induced ferroptosis in vivo, providing clues for molecular imaging and drug development of ferroptosis-related treatments.
Keywordmyocardial ischemia-reperfusion ferroptosis magnetic particle imaging quantitative visualization
DOI10.7150/thno.89190
Indexed BySCI
Sub direction classification医学影像处理与分析
planning direction of the national heavy laboratory其他
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/57097
Collection中国科学院分子影像重点实验室
Corresponding AuthorHui Hui; Jingjing Wang; Jie Tian
Affiliation1.Department of Cardiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences
2.National Clinical Research Center for Cardiovascular Diseases of Traditional Chinese Medicine
3.CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, the State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences
4.School of Engineering Medicine, Beihang University
5.College of Energy Engineering, Zhejiang university
6.Beijing University of Traditional Chinese Medicine Graduate School, Beijing University of Chinese Medicine, Beijing
7.Department of Cardiovascular Medicine, First Medical Center, General Hospital of the People's Liberation Army of China
8.Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wenwen Yang,Yueqi Wang,Changgeng Fu,等. Quantitative visualization of myocardial ischemia– reperfusion-induced cardiac lesions via ferroptosis magnetic particle imaging[J]. Theranostics,2024,14(3):1081-1097.
APA Wenwen Yang.,Yueqi Wang.,Changgeng Fu.,Changjian Li.,Feng Feng.,...&Linzi Long.(2024).Quantitative visualization of myocardial ischemia– reperfusion-induced cardiac lesions via ferroptosis magnetic particle imaging.Theranostics,14(3),1081-1097.
MLA Wenwen Yang,et al."Quantitative visualization of myocardial ischemia– reperfusion-induced cardiac lesions via ferroptosis magnetic particle imaging".Theranostics 14.3(2024):1081-1097.
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