CASIA OpenIR  > 中国科学院分子影像重点实验室
Enhanced TfR1 Recognition of Myocardial Injury after Acute Myocardial Infarction with Cardiac Fibrosis via Pre-Degrading Excess Fibrotic Collagen
Wenwen Yang1,2; Yueqi Wang2; Hongzheng Li1; Feifei Liao1; Yuxuan Peng1; Aimei Lu1; Ling Tan1; Hua Qu1; Linzi Long1; Changgeng Fu1
Source Publicationbiology
2024
Volume13Issue:4Pages:213
Abstract

The fibrosis process after myocardial infarction (MI) results in a decline in cardiac function due to fibrotic collagen deposition and contrast agents’ metabolic disorders, posing a significant challenge to conventional imaging strategies in making heart damage clear in the fibrosis microenvironment. To address this issue, we developed an imaging strategy. Specifically, we pretreated myocardial fibrotic collagen with collagenase I combined with human serum albumin (HSA-C) and subsequently visualized the site of cardiac injury by near-infrared (NIR) fluorescence imaging using an optical contrast agent (CI, CRT-indocyanine green) targeting transferrin receptor 1 peptides (CRT). The key point of this strategy is that pretreatment with HSA-C can reduce background signal interference in the fibrotic tissue while enhancing CI uptake at the heart lesion site, making the boundary between the injured heart tissue and the normal myocardium clearer. Our results showed that compared to that in the untargeted group, the normalized fluorescence intensity of cardiac damage detected by NIR in the targeted group increased 1.28-fold. The normalized fluorescence intensity increased 1.21-fold in the pretreatment group of the targeted groups. These data demonstrate the feasibility of applying pretreated fibrotic collagen and NIR contrast agents targeting TfR1 to identify ferroptosis at sites of cardiac injury, and its clinical value in the management of patients with MI needs further study.

Keywordmyocardial infarction human serum albumin collagenase I transferrin receptor 1 near-infrared fluorescence imaging
DOI10.3390/biology13040213
Indexed BySCI
Sub direction classification医学影像处理与分析
planning direction of the national heavy laboratory其他
Paper associated data
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/57131
Collection中国科学院分子影像重点实验室
Affiliation1.Graduate School, China Academy of Chinese Medical Sciences
2.CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wenwen Yang,Yueqi Wang,Hongzheng Li,et al. Enhanced TfR1 Recognition of Myocardial Injury after Acute Myocardial Infarction with Cardiac Fibrosis via Pre-Degrading Excess Fibrotic Collagen[J]. biology,2024,13(4):213.
APA Wenwen Yang.,Yueqi Wang.,Hongzheng Li.,Feifei Liao.,Yuxuan Peng.,...&Changgeng Fu.(2024).Enhanced TfR1 Recognition of Myocardial Injury after Acute Myocardial Infarction with Cardiac Fibrosis via Pre-Degrading Excess Fibrotic Collagen.biology,13(4),213.
MLA Wenwen Yang,et al."Enhanced TfR1 Recognition of Myocardial Injury after Acute Myocardial Infarction with Cardiac Fibrosis via Pre-Degrading Excess Fibrotic Collagen".biology 13.4(2024):213.
Files in This Item: Download All
File Name/Size DocType Version Access License
biology-杨文文.pdf(4259KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wenwen Yang]'s Articles
[Yueqi Wang]'s Articles
[Hongzheng Li]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wenwen Yang]'s Articles
[Yueqi Wang]'s Articles
[Hongzheng Li]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wenwen Yang]'s Articles
[Yueqi Wang]'s Articles
[Hongzheng Li]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: biology-杨文文.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.