CASIA OpenIR  > 中国科学院分子影像重点实验室
Application of Epithelial Growth Factor Receptor-Targeted Magnetic Resonance Imaging and Near-Infrared II Dual-Modal Probe in Lung Cancer Diagnosis and Surgical Resection
Chao Li1; Changjian Li2,3; jian Zhou1; Yueqi Wang4; Hainan Wu,1; Luzheng Xu1; Yifeng Li2,3; Xizhao Sui1; Guanchao Jiang1; Yun Li1; Zhenhua Hu4; Jie Tian2,3,4; Fan Yang1,5
Source PublicationMOLECULAR PHARMACEUTICS
2024-04-30
Pages1543-8392
Abstract

There has been an increase in the use of molecular probe diagnostic techniques for lung cancer, and magnetic resonance imaging (MRI) offers specific advantages for diagnosing pulmonary carcinoma. Furthermore, advancements in near-infrared II (NIR-II) fluorescence have provided a new method for precise intraoperative tumor resection. However, few probes combine preoperative diagnosis with intraoperative imaging. This study aims to fill this research void by employing a dual-modal probe that targets the epidermal growth factor receptor for MR and NIR-II imaging, enabling the preoperative diagnosis of lung cancer using MRI and precise intraoperative tumor localization using NIR-II with a single probe. The imaging effects and targeting ability of the probe were confirmed in cell lines, mouse models, and clinical samples. The MR signal decreased within 24 h in the patient-derived xenograft mouse model. The average signal-to-background ratio of NIR-II reached 3.98 ± 0.27. The clinical sample also showed a decrease in the T2 signal using MRI, and the NIR-II optical signal-to-background ratio was 3.29. It is expected that this probe can improve the diagnostic rate of lung cancer using MRI and enable precise intraoperative tumor resection using NIR-II.

DOI10.1021/acs.molpharmaceut.3c01137
Indexed BySCI
Language英语
Sub direction classification医学影像处理与分析
planning direction of the national heavy laboratory其他
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/57353
Collection中国科学院分子影像重点实验室
Affiliation1.Peking University People's Hospital
2.School of Engineering Medicine, Beihang University
3.Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology
4.CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences
5.Peking University Medical and Health Analysis Center
Recommended Citation
GB/T 7714
Chao Li,Changjian Li,jian Zhou,et al. Application of Epithelial Growth Factor Receptor-Targeted Magnetic Resonance Imaging and Near-Infrared II Dual-Modal Probe in Lung Cancer Diagnosis and Surgical Resection[J]. MOLECULAR PHARMACEUTICS,2024:1543-8392.
APA Chao Li.,Changjian Li.,jian Zhou.,Yueqi Wang.,Hainan Wu,.,...&Fan Yang.(2024).Application of Epithelial Growth Factor Receptor-Targeted Magnetic Resonance Imaging and Near-Infrared II Dual-Modal Probe in Lung Cancer Diagnosis and Surgical Resection.MOLECULAR PHARMACEUTICS,1543-8392.
MLA Chao Li,et al."Application of Epithelial Growth Factor Receptor-Targeted Magnetic Resonance Imaging and Near-Infrared II Dual-Modal Probe in Lung Cancer Diagnosis and Surgical Resection".MOLECULAR PHARMACEUTICS (2024):1543-8392.
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