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Alternative TitleMethodology and Applications of Functional Near-infrared Spectroscopy
Thesis Advisor蒋田仔
Degree Grantor中国科学院研究生院
Place of Conferral中国科学院自动化研究所
Degree Discipline模式识别与智能系统
Keyword功能近红外光谱成像 前额叶 抑郁症 精神分裂症 Functional Near-infrared Spectroscopy (Fnirs) Prefrontal Cortex (Pfc) Depression Schizophrenia
Abstract功能近红外光谱成像是近年来快速发展起来的一种利用近红外光对大脑皮层功能活动进行无创检测的成像技术。由于近红外光在大脑组织中主要被氧合血红蛋白和脱氧血红蛋白吸收,且这两种色团对近红外光又有不同的吸收特性,因此,当使用两个或多个波长便可以解算出大脑内由于神经活动引起的氧合血红蛋白和脱氧血红蛋白浓度的变化。近红外光谱成像具有一系列优点,例如非侵入性,操作简便,价格相对低廉等,因此功能近红外光谱成像已经成为各种神经精神疾病应用研究的重要手段之一。本文以功能近红外光谱成像为手段,以高级认知功能的机理及检测方法为突破口,考察重大精神疾病患者在认知任务下脑功能活动的异常,从而加深对精神疾病病理机制的理解和认识。本文的工作主要体现在以下几个方面: 1. 采用多种认知任务,包括言语流畅性任务和stroop色词任务,考察了抑郁症患者的前额叶激活模式。研究结果表明,抑郁症患者在完成两种不同的认知任务时都表现出前额叶激活减弱。这一研究结果支持抑郁症患者的认知障碍与前额叶功能紊乱有关。 2. 将影像学特征与临床诊断相结合,利用大脑前额叶在执行认知任务时的激活模式作为特征,设计分类器来对抑郁症患者和正常对照进行分类。结果发现总的分类正确率可以达到88%,其中病人的正确率可以达到92%。这表明用功能近红外光谱成像检测到的信息实现对疾病的自动分类是可行的,证明了功能近红外光谱成像在精神疾病的临床诊断和治疗方面的潜力。 3. 伦敦塔任务是检测执行与计划能力的经典神经心理学测试,我们首次用功能近红外光谱成像考察首发精神分裂症患者在伦敦塔任务下的大脑前额叶功能活动。我们发现精神分裂症患者的前额叶激活程度较正常人显著减弱,并且精神分裂症患者在患病初期就存在认知功能障碍。本研究进一步证明了功能近红外光谱成像具备研究精神疾病患者脑功能活动的临床应用方面的潜力。
Other AbstractFunctional near-infrared spectroscopy (fNIRS) is a newly developed non-invasive brain imaging technology with the advantages such as low instrument cost and noninvasive characteristic. Near-infrared light can penetrate cerebral tissue and is mainly absorbed by oxygenated ([Oxy-Hb]) and deoxygenated ([Deoxy-Hb]) hemoglobin, which have different light absorption characteristics in the near-infrared range. fNIRS can detect cerebral oxygen saturation by measuring the change of intensity of near-infrared light. Functional near-infrared spectroscopy has become an important tool in studying brain disorder for patients with neurological and psychiatric diseases. Therefore, in this study we will investigate the brain functional activities of the patients with serious psychiatric diseases and to explore the pathophysiology of psychiatric disorders. The main contents and contributions of the study are summed as follows: 1. With verbal fluency task and Stroop color-word task, we evaluated prefrontal activation pattern in individuals with elderly depression using fNIRS. We found decreased activation in the prefrontal cortex in the both tasks. This result support prefrontal dysfunction during cognitive tasks in depressed patients. 2. We proposed a multivariate classification approach for distinguishing patients with elderly depression from normal controls based on the prefrontal activation pattern measured by fNIRS during a cognitive task. The experimental results indicate that the proposed method can achieve a satisfactory classification with the accuracy 88% for total and 92% for patients. Also, the results suggested that fNIRS may be a promising clinical tool in the diagnosis and treatment of psychiatric disorders. 3. The Tower of London (TOL) task is a classical neuropsychological task to assess planning ability. We applied the TOL planning task to evaluate prefrontal dysfunction in schizophrenia patients using fNIRS. The results clearly showed that a decreased activation in the prefrontal cortex while performing TOL task for the first-episode schizophrenia patients, suggesting the planning ability has been impaired in their prefrontal cortex. Our results may be also potentially useful for applying to fNIRS on the clinical setting of psychiatric disorders.
Other Identifier200618014628064
Document Type学位论文
Recommended Citation
GB/T 7714
祝晔. 功能近红外光谱成像的计算方法及其应用研究[D]. 中国科学院自动化研究所. 中国科学院研究生院,2011.
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