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基于离散外微分方法的血管瘤栓塞手术近实时仿真
Alternative TitleToward Real-Time Simulation of Aneurysm Coil Embolization Using the Discrete Exterior Calculus Method
韦伊伊
Subtype工学博士
Thesis Advisor马颂德
2013-11-29
Degree Grantor中国科学院大学
Place of Conferral中国科学院自动化研究所
Degree Discipline控制理论与控制工程
Keyword实时医学仿真 血管瘤微弹簧圈栓塞 离散外微分 血流仿真 流体结构的相互作用 Real-time Medical Simulation Aneurysm Coil Embolization Discrete Exterior Calculus Blood Flow Simulation Fluid-structure Interaction
Abstract在近十几年里,颅内血管瘤的治疗已取得了显著进展。当前最有效的手术治疗方案是采用先进的微创技术,使用白金质地的微弹簧圈栓塞血管瘤,以阻碍其继续扩张,防止破裂。但该手术操作极其复杂,要求医生有丰富的临床经验和娴熟的操作技巧,才能保证较高的成功率。为辅助血管瘤疾病的治疗,一个理想的计算机系统能帮助医生针对不同患者的个性化案例交互地选择和测试不同尺寸和形状的微弹簧圈,演练手术操作,并能预测血管瘤的生长和破裂。这不仅涉及血管瘤几何模型的重建,还包括血液、血管壁和医疗设备的物理建模,及其相互作用的仿真。针对此类系统的构建,本文展开了深入的研究,取得的主要成果如下: 第一,首次将离散外微分(Discrete Exterior Calculus,简称DEC)方法引入血液动力学仿真中,并从理论和实验上详细分析了该方法的准确性、稳定性和计算效率。特别地,通过优化网格和高阶积分进一步提高了该数值方法的稳定性,并采用多种加速技术减少了运算时间, 从而提升了该方法在医学仿真中应用的可行性。 第二,基于DEC方法,提出了一个新框架(近)实时仿真微弹簧圈栓塞手术。该方法采用从医学图像中重建的个性化血管瘤几何模型,首次考虑了血液与微弹簧圈之间的双向作用:血流对微弹簧圈填充过程的影响;已填入的微弹簧圈对血管瘤内血流的影响。实验结果表明,针对双向作用的仿真,能有效地帮助医生动态规划手术中最关键的两个步骤:选择和填充第一根微弹簧圈;预测栓塞效果以确定所需的微弹簧圈总量。 第三,提出了一种新方法模拟血管瘤的生长过程,该框架基于高效计算的血液流动和软组织变形模型,采用松耦合交替迭代策略以及蠕变模型仿真血液与软组织之间相互作用的长期结果,同时考虑了血管瘤周围其他组织对其生长的影响。我们在2维空间中用患者真实数据进行仿真,得到了与真实情况吻合的初步结果。
Other AbstractOver the last decade, remarkable progress has been made to treat cerebral aneurysm with endovascular strategies, essentially using platinum coils. Yet, coil embolization remains a very complex operation which requires careful planning and advanced skills in order to be successful. In this context, a computer-assisted system, allowing physicians to interactively select and test different coils in a patient-specific environment, could make a difference. This involves modeling the vascular structure, medical devices, but also blood flow and its interaction with coils. We introduce the Discrete Exterior Calculus method to hemodynamic simulation for the first time, along with a series of experiments to understand its accuracy, stability and computational efficiency. More importantly, we improve the numerical stability by optimizing meshes and using advanced backtracking schemes. We also apply several techniques for accelerating the computation. Based on this fast method, we propose a new approach for patient-specific and real-time simulation of coil embolization, from mesh generation to computation of blood-coil bilateral interactions, first involving the impact of flow on the coil during its deployment, and second concerning the decrease of blood velocity within the aneurysm. This allows dynamical planning for two key steps: choice and placement of the first coil, and assessment of coil packing. Our simulated results demonstrated that the bilateral influence is essential in the surgery planning. Besides, we propose a preliminary framework for the simulation of blood-vessel interaction during aneurysm growth, which shows encouraging results in the two-dimensional case.
shelfnumXWLW1948
Other Identifier200818014628065
Language中文
Document Type学位论文
Identifierhttp://ir.ia.ac.cn/handle/173211/6567
Collection毕业生_博士学位论文
Recommended Citation
GB/T 7714
韦伊伊. 基于离散外微分方法的血管瘤栓塞手术近实时仿真[D]. 中国科学院自动化研究所. 中国科学院大学,2013.
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