In recent years, how to quickly, accurately and objectively locate tumors and other lesions of the organization has been an internationally challenging issue for researchers. Existing medical imaging technology has played an important role in the preoperative diagnosis and postoperative assessment, however there are few methods designed for surgeons and suitable for intraoperative imaging. With the development of imaging techniques, surgical navigation technology with optical molecular imaging methods offers the potential to solve the problem. Optical molecular imaging is a method for imaging in a state of cellular levels in vivo quantitative and qualitative analysis. This method can be achieved on the organism early physiological and pathological changes in non-invasive, dynamic, continuous, in vivo imaging. Compared with other imaging techniques, molecular imaging method, which can be realized in early lesions in vivo imaging, take the advantage of high sensitivity, non-radioactivity, visualization results, real-time imaging and low cost. Surgical navigation technology is a method which can help surgeons intraoperatively accurately locate the tumor tissue and precisely resect the lesions. This paper focuses on how to accurately locate the breast cancer tissues with early stage diagnosis. The surgical navigation system with optical molecular imaging method has been developed and some pre-clinical and clinical applications have been carried out to prove its feasible usage. The research has mainly focus on how to further improve the robustness and reliability of our system and proposed the effective design for the system configuration. The main contents include the following points: 1. A multi-spectral imaging method based on the fluorescence molecular imaging has been proposed. With the design of optical molecular imaging method, it can be realized that the anatomical structure and tissue-specific images were real-time displayed during the surgery. Our experimental results show that this method has the reliability and stability for clinical usage. 2. According to the intraoperative convenience for surgeons to pinpoint the lesion tissue, a suitable architecture design method was proposed in our system for surgeons’ usage during surgery. This method can be adjusted to any angle within the space. And the operation process does not affect the use of the conventional surgical procedure. With the guidance of our system, tumor-specific images can be feedbac...
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