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Alternative TitleSoftware Development And Clinical Application for Surgical Navigation System with Optical Molecular Imaging
Abstract如何在手术过程中实现肿瘤的早期发现以及精确定位一直是医学临床领域的挑战性问题。放射性核素成像、计算机断层成像和磁共振成像等成像技术主要用于术前成像。分子影像学是一门新兴的综合交叉学科,它主要是通过影像学技术和方法,在细胞以及分子水平上对活体状态下的生物进行定性和定量研究。光学分子影像是分子影像学的重要组成部分及有生力量,它具有灵敏度高、非侵入性、非接触、非电离辐射、特异性强等优势。以光学分子影像技术为核心的光学分子影像手术导航技术能够在术中为医生提供实时的影像导航,引导医生快速、准确地确定肿瘤等病变的位置,对于肿瘤的早期发现及术中探测具有重要的意义。在光学分子影像手术导航技术中,应用软件负责获取、处理和显示手术导航的影像信息,是实现术中导航、定位的关键,也是导航系统与医生交互的主要媒介。 本文针对光学分子影像手术导航系统应用软件的研发和临床应用进行了研究,针对软件的稳定性以及有效性进行验证。实现了应用软件的研发以及在乳腺癌患者前哨淋巴结(Sentinel Lymph Node, SLN)活检手术中的预临床及临床验证,本文的主要研究内容包括以下几点: 1. 针对实际临床应用中的操作需求,设计了光学分子影像手术导航系统应用软件的架构,并将应用软件分成如下五个模块:(1)设备控制模块;(2)图像抓取模块;(3)实时显示模块;(4)图像处理模块;(5)数据存储模块。 2. 实现了光学分子影像手术导航系统应用软件各个模块的具体功能。针对应用软件框架设计中划分的各个模块,详细介绍了各个模块的具体功能和实现细节。 3. 开展了光学分子影像手术导航系统的预临床与临床应用研究。在预临床研究中,探索了荧光染料ICG(Indocyanine Green)使用的一些基本参数。在临床应用研究中,将光学分子影像手术导航结合ICG检测前哨淋巴结的方法与传统检测前哨淋巴结的方法进行了对比。同时,验证了光学分子影像手术导航系统应用软件具有良好的稳定性和有效性。
Other AbstractTo locate tumor accurately during surgery has always been a challenging problem in the field of clinical medicine. Radionuclide imaging technique, computed tomography technique and magnetic resonance technique are difficult to realize real-time intraoperative imaging. Optical molecular imaging (OMI) is a useful method for intraoperative imaging, which has received increased attention. As an important modality of OMI, fluorescence molecular imaging is able to provide high sensitivity and real-time image-guidance for surgeons. In recent years, fluorescence-based surgical navigation imaging for intraoperative detection of sentinel lymph node and tumor is evaluated as a new method. Several research teams have successfully developed different surgical navigation systems with fluorescent molecular imaging technique. The imaging software is the key part of the surgical navigation system (SNS) with OMI due to its ability of real-time data process, image display and data transfer. In this thesis, researches on imaging software development and clinical applications for SNS with OMI are conducted, and the features of the imaging software are introduced in detail. The main contributions of the thesis are listed as follows: (1) We designed the software architecture based on the clinical requirements. The software architecture consists of the following modules, which mainly include the control module, the image grabbing module, the real-time display module, the data saving module and the image processing module. (2) We implemented the function of the imaging software. The development tools as well as the implementation details of the imaging software were introduced in detail. (3) We conducted the preclinical and clinical study using the SNS on sentinel lymph node (SLN) detection in breast cancer patients. In the preclinical study, we explored the optimized injection time and dosage of indocyanine green (ICG) for SLN detection. In the clinical study, we compared of the ICG and methylene blue dye methods in detection of SLN in breast cancer patients. The results demonstrated that SLN detection with our SNS was practical and applicable.
Keyword光学分子影像 手术导航 应用软件 乳腺癌 前哨淋巴结活检 Optical Molecular Imaging Surgical Navigation Imaging Software Sentinel Lymph Node Breast Cancer
Document Type学位论文
Recommended Citation
GB/T 7714
叶津佐. 光学分子影像手术导航系统的软件开发与临床应用[D]. 中国科学院自动化研究所. 中国科学院大学,2014.
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